Influence of zoledronic acid and low-intensity laser on collagen fibers during the bone repair process.

PURPOSE: To evaluate collagen fibers during the bone repair process in critical defects created in the tibias of rats, treated with zoledronic acid (AZ) associated with low-level laser therapy (LLLT). METHODS: Ten rats were distributed according to treatment: group 1) saline solution; group 2) LLLT; group 3) AZ; group 4) AZ and LLLT. AZ was administered at the dose of 0.035 mg/kg at fortnightly intervals over eight weeks. Next, 2-mm bone defects were created in the tibias of all animals. The bone defects in groups 2 and 4 were irradiated LLLT in the immediate postoperative period. After periods 14 and 28 of application, the animals were euthanized, and birefringence analysis was performed. RESULTS: Approximately 90% of the total area was occupied by collagen fibers within the red color spectrum, this area being statistically larger in relation to the area occupied by collagen fibers within the green and yellow spectrum, in the four groups. Over the 14-day period, there was no statistically significant difference between the groups. In the 28-day period, group 2 (14.02 ± 15.9%) was superior in quantifying green birefringent fibers compared to group 1 (3.06 ± 3.24%), with p = 0.009. CONCLUSIONS: LLLT associated with ZA is effective in stimulating the neoformation of collagen fibers. The LLLT group without the association with ZA showed a greater amount of immature and less organized matrix over a period of 28 days.

Effect of S53P4 bioactive glass and low-level laser therapy on calvarial bone repair in rats submitted to zoledronic acid therapy.

PURPOSE: To evaluate the influence of bioactive glass and photobiomodulation therapy (PBMT) in calvarial bone repair process in rats submitted to zoledronic acid therapy. METHODS: Twenty-four rats were selected and treated with the dose of 0.035 mg/kg of zoledronic acid every two weeks, totalizing eight weeks, to induce osteonecrosis. After the drug therapy, surgical procedure was performed to create 5-mm diameter parietal bone defects in the calvarial region. The rats were then randomly assigned to groups according to the following treatments: AZC: control group, treated with blood clot; AZBIO: bone defect filled with bioactive glass; AZL: treated with blood clot and submitted to PBMT; and AZBIOL: treated with bioactive glass S53P4 and submitted to PBMT. Tissue samples were collected and submitted to histomorphometric analysis after 14 and 28 days. RESULTS: At 14 days, bone neoformation in the AZBIO (52.15 ± 9.77) and AZBIOL (49.77 ± 13.58) groups presented higher values (p ≤ 0.001) compared to the AZC (23.35 ± 10.15) and AZL groups (23.32 ± 8.75). At 28 days, AZBIO (80.24 ± 5.41)still presented significant higher bone recovery values when compared to AZC (59.59 ± 16.92)and AZL (45.25 ± 5.41) groups (p = 0.048). In the 28-day period, the AZBIOL group didn't show statistically significant difference with the other groups (71.79 ± 29.38). CONCLUSIONS: The bioactive glass is an effective protocol to stimulate bone neoformation in critical defects surgically created in rats with drug induced osteonecrosis, in the studied periods of 14 and 28 days.

Hospital Intervention in Severe Sinus Infection After Bone Graft.

This study presents the case of a patient who required antrostomy under general anesthesia to treat a sinus lift complication. The patient was a 43-year-old woman with no systemic abnormalities who underwent maxillary sinus lift surgery associated with mineralized bovine bone graft. The Schneiderian membrane was perforated during the procedure, and the rupture was treated with collagen membranes to close the wound and contain the biomaterial, preventing its dispersion. The patient developed a maxillary sinus infection 7 days after surgery. This infection was initially treated with 875 mg amoxicillin combined with 125 mg clavulanic acid. Although the initial infection did not worsen, the patient developed maxillary sinusitis. Thirty days after the onset of the initial infection, the patient underwent an intraoral surgery under local anesthesia to remove the biomaterial and clean the sinus cavity. Despite this procedure, maxillary ostial patency was still compromised, and antrostomy was performed endoscopically in a hospital setting under general anesthesia. This procedure resolved the sinus infection. Then, 12 months after hospitalization, the patient was treated with another sinus graft surgery without postoperative complications. The treatment of sinus infections caused by the graft surgery may require early and active intervention with antibiotics, graft removal, and antrostomy to prevent major complications.

Effect of S53P4 bioactive glass and low-level laser therapy on calvarial bone repair in rats submitted to zoledronic acid therapy

ABSTRACT Purpose To evaluate the influence of bioactive glass and photobiomodulation therapy (PBMT) in calvarial bone repair process in rats submitted to zoledronic acid therapy. Methods Twenty-four rats were selected and treated with the dose of 0.035 mg/kg of zoledronic acid every two weeks, totalizing eight weeks, to induce osteonecrosis. After the drug therapy, surgical procedure was performed to create 5-mm diameter parietal bone defects in the calvarial region. The rats were then randomly assigned to groups according to the following treatments: AZC: control group, treated with blood clot; AZBIO: bone defect filled with bioactive glass; AZL: treated with blood clot and submitted to PBMT; and AZBIOL: treated with bioactive glass S53P4 and submitted to PBMT. Tissue samples were collected and submitted to histomorphometric analysis after 14 and 28 days. Results At 14 days, bone neoformation in the AZBIO (52.15 ± 9.77) and AZBIOL (49.77 ± 13.58) groups presented higher values (p ≤ 0.001) compared to the AZC (23.35 ± 10.15) and AZL groups (23.32 ± 8.75). At 28 days, AZBIO (80.24 ± 5.41)still presented significant higher bone recovery values when compared to AZC (59.59 ± 16.92)and AZL (45.25 ± 5.41) groups (p = 0.048). In the 28-day period, the AZBIOL group didn't show statistically significant difference with the other groups (71.79 ± 29.38). Conclusions The bioactive glass is an effective protocol to stimulate bone neoformation in critical defects surgically created in rats with drug induced osteonecrosis, in the studied periods of 14 and 28 days.

Computer guided surgery in the maxillary esthetic zone / Cirurgia guiada por computador em área estética da maxila

ABSTRACT This clinical report describes the implant rehabilitation for the treatment of pathological roots resorption due to inadequate orthodontic movement in prosthetic space reduced by means of load and immediate implants, computer-guided surgery and use of the own tooth crown in a 21-year-old-patient. The atraumatic exodontics of the right and left upper lateral incisors was performed, and then immediate placement of osseointegrated implants using the computer guided surgery technique. The crown teeth itself was used in the immediate aesthetic and functional rehabilitation. Completion of the treatment resulted in a functional and aesthetic successful outcome and a 27 months follow-up presented uneventful. The procedures included in this complex rehabilitation treatment in the esthetic zone were appropriate and essential for the maintenance of the soft and hard tissues contour and thickness ensuring the excellence in rehabilitation.

RESUMO Este relato de caso clínico descreve a reabilitação com implantes para o tratamento da reabsorção radicular patológica devido à movimentação ortodôntica inadequada em espaço protético reduzido, por meio implante imediato e carga imediata, pela técnica da cirurgia guiada por computador e uso da própria coroa dentária, em paciente de 21 anos. A exodontia atraumática dos incisivos laterais superiores direito e esquerdo foi realizada, em seguida realizou-se a instalação imediata dos implantes osseointegráveis, utilizando a técnica de cirurgia guiada por computador. Os próprios dentes da coroa foram usados na reabilitação estética e funcional imediata. A conclusão do tratamento resultou em sucesso funcional e estético com acompanhamento de 27 meses sem intercorrências. Os procedimentos incluídos neste complexo tratamento de reabilitação na zona estética foram adequados e essenciais para a manutenção do contorno e espessura dos tecidos moles e duros garantindo a excelência na reabilitação.

Surgical complications in systemically compromised patients: analysis of 992 medical records / Complicações cirúrgicas em pacientes comprometidos sistemicamente: análise de 992 prontuários

ABSTRACT Objective: The preoperative evaluation is essential to prevent postoperative surgical complications. The present study aimed to establish quantitative and qualitative profiles of systemic disorders and relate them to postoperative surgical complications in patients subjected to dental extraction Methods: Data were collected from the medical records of 992 patients subjected to dental extractions from 2010 to 2015 through a detailed analysis of anamnesis files. The data collected were tabulated and converted to percentages to facilitate the discussion and comparison with reports in the literature Results: From all the medical records analyzed, 559 presented systemic changes, which corresponds to 56.3%. Among them, there was a higher prevalence of patients with hypertension (24%), smoking habits (20%), and diabetes (11%). The most frequent complications were pain (34%), inflammation (19.8%), and hemorrhage (13.2%). The prevalence of diseases related to age shows patients under the age of 20 (4.7%), 20 to 29 (11.3%), 30 to 39 (16.8%), 40 to 44 (10%), 45 to 49 (10.9%), 50 to 54 (12.3%), 55 to 59 (12.9%), 60 to 64 (10.4%), 65 to 69 (4.8%), and older than 70 years old (5.9%). As for systemic changes with complications, hypertensive patients with complications (n=11) showed higher prevalence of pain (45.4%), the most common complication in smokers (n=15) was exacerbated inflammation (33.3%), and 50% of diabetic patients with complications (n=8) were diagnosed with alveolitis Conclusion: The method studied allowed concluding there was a relationship between postoperative complications and systemic changes, and the main ones were pain-hypertension, inflammation-smoking, and alveolitis-diabetes.

RESUMO Objetivo: A avaliação pré-operatória é de fundamental importância para a prevenção das complicações cirúrgicas pós-operatórias. O objetivo do presente estudo foi estabelecer um perfil quantitativo e qualitativo das enfermidades sistêmicas e relaciona-las com complicações cirúrgicas pós-operatórias em pacientes submetidos exodontia. Métodos: Para isso foram coletados dados de 992 prontuários de paciente submetidos a exodontias no período de 2010 a 2015, por meio da análise minuciosa da ficha de anamnese. Os dados obtidos foram tabulados e transformados em porcentagem, para facilitar a discussão e comparação com os relatos da literatura. Resultados: No total de prontuários analisados, 559 apresentaram alterações sistêmicas, o que corresponde a 56,3%. Dentre elas, houve uma maior prevalência de pacientes com hipertensão (24%), tabagismo (20%) e diabetes (11%). As complicações mais frequentes foram dor (34%), inflamação (19,8%) e hemorragia (13,2%). Considerando-se a prevalência de doenças relacionadas à idade, a faixa etária de menor de 20 anos (4.7%), 20 a 29 (11.3%), 30 a 39 (16.8%), 40 a 44 (10%), 45 a 49 (10.9%), 50 a 54 (12.3%), 55 a 59 (12.9%), 60 a 64 (10.4%), 65 a 69 (4.8%), e maiores de 70 anos (5.9%). Relacionando as alterações sistêmicas com as complicações, dentre os pacientes hipertensos que apresentaram complicações (n=11), a dor foi a mais prevalente (45,4%). Já nos fumantes (n=15) a complicação mais comum foi a inflamação exacerbada (33,3%). Nos diabéticos com presença de complicações (n=8), 50% foram diagnosticados com alveolite. Conclusão: Com base na metodologia estudada foi possível concluir que houve relação das complicações pós-operatórias e alterações sistêmicas, sendo as principais dor-hipertensão, inflamação-tabagismo e alveolite-diabetes.

Effect of low-level laser therapy and zoledronic acid on bone repair process.

This study aimed to evaluate, through histomorphometric analysis, the bone repair process in the tibia of rats treated with zoledronic acid and submitted to 808-nm low-level laser therapy (LLLT) by using arsenide aluminum gallium laser. For this purpose, 20 rats were used and distributed according to treatment: group 1-saline administration; group 2-treated with LLLT; group 3-treated with zoledronic acid; and group 4-treated with zoledronic acid and LLLT. The zoledronic acid was administered at a dose of 0.035 mg/kg every 2 weeks for 8 weeks. Subsequently, bone defects of 2 mm were prepared in the tibias of all groups. The bone defects in groups 2 and 4 were irradiated with LLLT in the immediate post-operative period. After 14 and 28 days of application, the animals were submitted and euthanized for histomorphometric analysis. The results were submitted to statistical analysis (α = 5%), and the intragroup comparison was performed using the t test. On the other hand, for intergroup comparison, the ANOVA test was performed, and to the groups presenting statistically significant difference, the Student-Newman-Keuls test was used. In intergroup comparison, group 1 (mean ± SD= 45.2 ± 18.56%) showed a lower bone formation compared with groups 2 (64.13 ± 3.51%) (p = 0.358) and 4 (15.2 ± 78.22%) (p = 0.049), at the 14-day period. Group 3 (20.99 ± 7.42%) also presented a lower amount of neoformed bone tissue, with statistically significant difference when compared with groups 1 (p = 0.002), 2, and 4 (p ≤ 0,001). After 28 days, group 1 presented a lower amount of neoformed bone tissue compared with the other groups, with p = 0.020. Thus, it was concluded that LLLT associated with zoledronic acid is effective for stimulating bone formation in surgically created defects in rats, at the periods studied.

Use of Calcium Phosphate Cement for Repairing Bone Defects: Histomorphometric and Immunohistochemical Analyses.

This study aimed to assess the repair of surgically created bone defects filled with blood clot, autogenous bone, and calcium phosphate cement, by histomorphometric and immunohistochemical analyses. Ten adult male rabbits were used. Three bone defects were prepared with an 8-mm diameter trephine bur in the parietal region of each animal and filled with blood clot (Group BC), autogenous bone (Group AB), and calcium phosphate bone cement (Group CPC). The animals were euthanized at 40 and 90 postoperative days. The sections were subjected to histomorphometric analysis of the new bone formed inside the calvarial defects and immunohistochemical staining to determine the expression of osteocalcin (OC), osteopontin (OP), and tartrate-resistant acid phosphatase (TRAP) proteins. Histomorphometric data were analyzed statistically by analysis of variance and Tukey's post hoc test at 5% significance level. In the results at 40 and 90 days, Group AB differed significantly from Group CPC regarding the area of newly formed bone. The immunohistochemical analysis revealed expression of OP, OC, and TRAP proteins in all groups. Group AB showed prevalence of OC and OP, and lower TRAP expression. Therefore, the calcium phosphate bone cement assessed in the present study did not accelerate the protein expression dynamics during bone healing, compared with the autogenous group.

Deglutição e aspiração na implantodontia / Deglutition and aspiration on implantology / Deglución y aspiración en implantología

Introdução: O tratamento com implantes e próteses implanto-suportadas tem sido amplamente utilizado em áreas edêntulas, aumentando assim o risco de acidentes e complicações. Dentre os acidentes em implantodontia destaca-se A migração de implantes e componentes para a orofarínge ocasionando em deglutição ou aspiração. Objetivo: O presente trabalho teve como objetivo, abordar acidentes relacionados à deglutição e aspiração, focando no tratamento e prevenção dos mesmos, por meio de uma revisão da literatura e relato de dois casos clínicos, ilustrando as intercorrências. Resultados: Os acidentes de deglutição e aspiração, apesar não frequentes, podem acontecer em qualquer tratamento odontológico, sendo de extrema importância o emprego de métodos preventivos. Em geral são assintomáticos e o diagnóstico por imagem se faz necessário para localização do objeto e definição de plano de tratamento. Conclusão: A deglutição é um acidente de fácil tratamento, pois geralmente com dieta rica em fibras o objeto pode ser expelido. Já no caso de aspiração, o paciente deve ser encaminhado a um centro de emergência e submetido a uma laringoscopia ou broncoscopia(AU)

Background: Treatment with implant-supported implants and implants has been widely used in edentulous areas, thus increasing the risk of accidents and complications. Among the accidents in implant dentistry are the components and implants that penetrate the oropharynx, causing swallowing or aspiration. Aim: The present study had to objective, address accidents related to swallowing and aspiration, focusing on their treatment and prevention, through a review of the literature and a report of a clinical case. Results: The swallowing and aspiration accidents, although not frequent, can happen in any dental treatment, being of extreme importance preventive methods. In general, they are asymptomatic and the diagnosis by imaging is necessary to locate the object and define the treatment plan. Conclusion: Swallowing is an easy treat accident, since usually with a high fiber diet the object can be expelled. In the case of aspiration, the patient should be referred to an emergency center and submitted to a laryngoscopy or bronchoscopy(AU)

Introducción: El tratamiento con implantes y prótesis implanto-soportadas ha sido ampliamente utilizado en áreas edéntulas, aumentando así el riesgo de accidentes y complicaciones. Entre los accidentes en implantodoncia se destaca la migración de implantes y componentes para la orofarínge ocasionando en deglución o aspiración. Meta: El presente trabajo tuvo como objetivo, abordar accidentes relacionados con la deglución y aspiración, enfocándose en el tratamiento y prevención de los mismos, por medio de una revisión de la literatura y relato de dos casos clínicos, ilustrando las intercurrencias. Resultado: Los accidentes de deglución y aspiración, aunque no frecuentes, pueden ocurrir en cualquier tratamiento odontológico, siendo de extrema importancia métodos preventivos. En general son asintomáticos y el diagnóstico por imagen se hace necesario para localización del objeto y definición de plan de tratamiento. Conclusión: La deglución es un accidente de fácil tratamiento, pues generalmente con dieta rica en fibras el objeto puede ser expulsado. En el caso de aspiración, el paciente debe ser encaminado a un centro de emergencia y sometido a una laringoscopia o broncoscopia(AU)

Tratamento cirúrgico da limitação de abertura bucal causada por hiperplasia do processo coronoide: relato de caso / Surgical treatment for mouth opening limitation caused by coronoid process hyperplasia: case report

A hiperplasia do processo coronoide é uma condiçãoincomum de etiologia desconhecida que se apresentaclinicamente por meio da limitação de abertura bucal enão possui sintomatologia dolorosa durante a aberturae o fechamento bucal. Objetivo: relatar e discutir, pormeio de um caso cirúrgico, o tratamento da limitaçãode abertura bucal causada por hiperplasia bilateral doprocesso coronoide. Relato de caso: paciente do sexofeminino, com 11 anos de idade, foi encaminhada paraatendimento devido à dificuldade de mastigação emfunção da limitação de abertura bucal, sem históricode trauma em face ou na região articular. O exame tomográficoevidenciou o alongamento bilateral do processocoronoide, fazendo com que ele colidisse com oarco zigomático durante a abertura bucal e causasse otravamento. O tratamento proposto foi a coronoidectomiabilateral com acesso cirúrgico intraoral, obtendono pós-cirúrgico imediato um ganho na abertura bucal.Considerações finais: a coronoidectomia é uma abordagemcirúrgica de fácil acesso por via intraoral, poucotraumática e eficaz no tratamento de pacientes com hiperplasiado processo coronoide. (AU)

The coronoid process hyperplasia is an unusual condition of unknown etiology that is presented clinically through mouth opening limitation, without painful symptoms during mouth opening and closure. Objective: to report and discuss, through a surgical case, the treatment of mouth opening limitation caused by bilateral coronoid process hyperplasia. Case report: female patient, 11 years old, referred due to chewing difficulty by mouth opening limitation. No history of trauma in the face or joint area. The tomographic examination showed the bilateral elongation of the coronoid process, causing it to collide with the zygomatic arch during mouth opening, which caused locking. The treatment proposed was bilateral coronoidectomy with intraoral surgical access, which enhanced mouth opening at the immediate postoperative period. Final considerations: coronoidectomy is a surgical approach with easy intraoral access, non-traumatic, and effective in the treatment of patients with coronoid process hyperplasia. (AU)

Cirurgia ortognática para tratamento da síndrome de apneia obstrutiva do sono: relato de caso

Objetivo: ilustrar, por meio de um caso clínico, os benefíciosdo tratamento da síndrome de apneia obstrutivade sono (Saos) por intermédio da cirurgia ortognáticabimaxilar, com o uso de biomateriais de reconstrução.Relato de caso: paciente encaminhado para avaliaçãode discrepância maxilomandibular em relação àbase do crânio e para avaliação de queixa de roncointenso durante a noite e intenso cansaço diurno. Apósavaliação e exames complementares, o paciente foidiagnosticado com apneia obstrutiva do sono; assim,foi realizada a cirurgia de avanço bimaxilar como terapêuticaresolutiva para o caso. Considerações finais:a Academia Americana de Medicina do Sono (AAMS)define Saos como uma doença que se caracteriza porepisódios repetitivos de obstrução total (apneia) ou parcial(hipopneia) das vias aéreas superiores durante osono. A cirurgia de avanço bimaxilar se apresenta comouma das melhores opções terapêuticas para os pacientescom essa síndrome. A cirurgia ortognática, incluindoseus diversos procedimentos, provoca importantesmudanças nas diferentes zonas das vias aéreas faríngeas.A cirurgia ortognática de avanço bimaxilar commentoplastia de avanço foi eficaz, em longo prazo, notratamento da Saos, e o uso simultâneo de biomateriaisde substituição óssea aumenta a estabilidade óssea primária,acelera o processo de reparo ósseo e diminui amorbidade pós-operatória.

Influência da extração na instalação imediata e estabilidade primária de implantes osseointegrados para reabilitação total: estudo clínico retrospectivo com 40 pacientes e 162 implantes / The influence of tooth extraction on the immediate implant placement and stability for complete mandibular rehabilitation: a clinical retrospective study with 40 patients and 162 dental implants

Objetivo: verificar a influência das exodontias realizadas no mesmo momento da instalação dos implantes osteointegráveis (IO) na frequência de complicações pós-operatórias e a estabilidade primária desses implantes. Material e métodos: mediante análise dos prontuários dos pacientes tratados na APCD (Bauru-SP), foram selecionados e comparados dois grupos de pacientes que necessitavam de reabilitação oral total de mandíbula. Grupo I: pacientes submetidos à exodontia prévia à instalação de IO (N:13). Grupo II: pacientes submetidos à exodontia e instalação de implantes no mesmo momento (N:27). No grupo I, dos 13 pacientes tratados, 12 (91,67%) foram submetidos à carga imediata (52 implantes). No grupo II, 24 (88,89%) dos 27 pacientes (110 implantes) alcançaram os parâmetros necessários de estabilidade inicial. Resultados: a comparação entre os grupos apontou maior frequência de complicações no grupo II, no qual foram perdidos dois implantes osteointegráveis (1,82%). Conclusão: as extrações realizadas no mesmo momento da instalação dos IO podem contribuir para maior incidência de perda das fixações. Assim, deve-se esclarecer aos pacientes as limitações, vantagens e desvantagens do tratamento com carga imediata.

Objectives: to verify the influence of tooth extraction and immediate implant placement on the frequency of postoperative complications and primary implant stability. Material and methods: upon reviewing of the dental charts of patients treated at APCD (Bauru- SP), two groups were selected based on their need of mandibular implant restorations. Group I: those submitted to tooth extraction and later receiving dental implant placement (N=13); Group II: patients submitted to extraction and implant placement in the same time (N=27). In Group I, 13 patients (91.67%) were submitted to immediate loading (52 implants). In Group II, 24 patients (110 implants, 88,89%) achieved the pre-requisites of initial stability. Results: the frequency of complications was higher in Group II, with two implants lost (1.82%). Conclusion: tooth extraction and dental implant placement in the same day can contribute to more implant failures. Thus, patients need to educated regarding the limitations, advantages, and disadvantages of the immediate loading protocol as a treatment option.

Rehabilitation using immediate loading in patients with partial resection of the jaw

ABSTRACT: Ameloblastoma is a rare tumor that affects the maxillomandibular region. Surgical resection is often indicated, and oral rehabilitation becomes a challenge. This study aims to report on the mandibular rehabilitation with implant supported prosthesis using immediate loading with subsequent resection. A patient with a confirmed diagnosis of multicystic ameloblastoma in the left jaw underwent a partial resection of the mandible and a reconstruction with a titanium plate. After 2 years of follow-up with clinical examinations and imaging testing and with no signs of recurrence, the patient underwent the technique of immediate load implants, rehabilitating the mandible with an implant supported fixed prosthesis and the maxilla with a conventional complete denture. During the seven years of follow-up with the patient, there was no sign of recurrence of ameloblastoma. The rehabilitation with oral implants under immediate loading demonstrated to be successful, and the cemented cylinder technique used in this study coupled with passivity showed a favorable prognosis for the longevity of implants.

Implant Anchorage in the Nasopalatine Canal for the Rehabilitation of Severely Atrophic Maxilla.

PURPOSE: This study aimed to describe the clinical case of implant placement in the nasopalatine canal as an aid for atrophic maxilla rehabilitation. CASE REPORT: The surgical procedure was carried out in 2 stages, the first part consisted of a surgery to lift the maxillary sinus membrane associated with the xenogeneic bone placement and the second part consisted of the surgery for the implants placement, both under local anesthesia. A number of seven osseointegrated implants were placed in the maxilla, one was anchored in the nasopalatine canal region after having its neurovascular content emptied by means of the use of drill threads of the implant system. After 5 months, the implant reopening was carried out, followed by the molding, manufacturing and placement of the protocol-type prosthesis. The case has a 4-year follow-up without any painful symptomatology. CONCLUSION: The implant placed in the nasopalatine canal region is a viable option to assist in the rehabilitation with implant-supported prostheses in atrophic maxilla.

Zygomatic Implant Subjected to Immediate Loading for Atrophic Maxilla Rehabilitation.

As life expectancy increases, a larger number of elderly people require dental health care attention for implant-supported rehabilitation, with the aim of restoring the function and aesthetics of the oral cavity. Most of these patients have lost their teeth long time ago, causing a severe bone resorption and maxillary sinus pneumatization. Therefore, the current study aims to demonstrate, through the description of the clinical case, the treatment with zygomatic implants as an option for treating severely atrophic maxillas. In this clinical study, the patient presented, in the clinical and image evaluation, severe alveolar bone atrophy, with height and thickness loss, in addition to a high-level pneumatization of the maxillary sinus, bilaterally. The classical zygomatic fixation technique was suggested, with 2 anterior conventional implants and 2 zygomatic implants in the posterior region with the placement of implant-supported prosthesis with immediate loading. The patient was monitored for 7 years and did not present pain complaints, absence of infection, or implant loss. Based on this clinical case study, it was concluded that the zygomatic implants are satisfactory options to aid the implant-supported rehabilitation of atrophic maxillas.

Evaluation of bone substitutes for treatment of peri-implant bone defects: biomechanical, histological, and immunohistochemical analyses in the rabbit tibia.

PURPOSE: We sought to evaluate the effectiveness of bone substitutes in circumferential peri-implant defects created in the rabbit tibia. METHODS: Thirty rabbits received 45 implants in their left and right tibia. A circumferential bone defect (6.1 mm in diameter/4 mm depth) was created in each rabbit tibia using a trephine bur. A dental implant (4.1 mm × 8.5 mm) was installed after the creation of the defect, providing a 2-mm gap. The bone defect gaps between the implant and the bone were randomly filled according to the following groups: blood clot (CO), particulate Bio-Oss(®) (BI), and Bio-Oss(®) Collagen (BC). Ten animals were euthanized after periods of 15, 30, and 60 days. Biomechanical analysis by means of the removal torque of the implants, as well as histologic and immunohistochemical analyses for protein expression of osteocalcin (OC), Runx2, OPG, RANKL, and TRAP were evaluated. RESULTS: For biomechanics, BC showed a better biological response (61.00±15.28 Ncm) than CO (31.60±14.38 Ncm) at 30 days. Immunohistochemical analysis showed significantly different OC expression in CO and BC at 15 days, and also between the CO and BI groups, and between the CO and BC groups at 60 days. After 15 days, Runx2 expression was significantly different in the BI group compared to the CO and BC groups. RANKL expression was significantly different in the BI and CO groups and between the BI and BC groups at 15 days, and also between the BI and CO groups at 60 days. OPG expression was significantly higher at 60 days postoperatively in the BI group than the CO group. CONCLUSIONS: Collectively, our data indicate that, compared to CO and BI, BC offered better bone healing, which was characterized by greater RUNX2, OC, and OPG immunolabeling, and required greater reversal torque for implant removal. Indeed, along with BI, BC presents promising biomechanical and biological properties supporting its possible use in osteoconductive grafts for filling peri-implant gaps.

Bone Volume Changes After Sinus Floor Augmentation with Heterogenous Graft.

PURPOSE: The aim of this study was to evaluate the volumetric stability of deproteinized bovine bone after sinus augmentation, using cone beam computed tomography (CBCT) and three-dimensional (3D) analysis. MATERIALS AND METHODS: Using a specific selection tool and 3D reconstruction from InVesalius 3.0, volumetric analysis of CBCT scans was performed in patients undergoing a sinus elevation technique in critical defects, using deproteinized bovine bone. The first scan was performed immediately after graft surgery (T1), and the second was performed 8 months after graft surgery (T2). RESULTS: A total of 13 patients met the inclusion criteria of this retrospective study; 26 postoperative CBCT scans were analyzed for these patients. All patients exhibited an increase in bone volume (9.10%). The mean bone volume increase from T1 to T2 was 0.137 cm(3) (SD: ± 0.104 cm(3)). There was a statistically significant correlation between bone volume and time (P < .0001). The mean bone volume was 1.506 cm(3) (SD: ± 0.473 cm(3)) for T1 and 1.644 cm(3) (SD: ± 0.506 cm(3)) for T2. CONCLUSION: Within the limited sample, the study demonstrated an increase in graft volume after sinus elevation with deproteinized bovine bone in critical defects.

Peri-implantite: tratamentos e manutenção peri-implantar ­ parte 2* / Peri-implantitis: treatments and maintenance ­ part II

Objetivo: orientar os profissionais a diagnosticar as doenças peri-implantares, conhecer suas características, avaliar os fatores de risco e escolher tratamentos adequados para cada situação. Material e métodos: a busca foi realizada nos bancos de dados Medline e EBSCO, entre 1992 e 2013, limitada aos artigos completos publicados em língua inglesa. Todos os níveis de evidência foram incluídos (relato de caso, experimentos em animais, revisões bibliográficas e estudos estatísticos com humanos). Resultados: o principal agente etiológico das doenças peri-implantares ainda é a placa bacteriana. No entanto, fatores de risco sistêmicos e locais influenciam no seu desenvolvimento. Os principais microrganismos presentes nas infecções peri-implantares são os mesmos encontrados na periodontite: bactérias gram e anaeróbicas. O tratamento não cirúrgico sozinho não apresentou resultados satisfatórios, contudo, quando associado com antisséptico bucal ou antibiótico, reduz a infecção. O tratamento cirúrgico permite o debridamento acurado da região peri-implantar, a descontaminação da superfície do implante e resulta em ganho de inserção clínica e reconstrução óssea. Conclusão: até o presente momento, nenhum protocolo padrão de tratamento da peri-implantite foi estabelecido. A prevenção e a manutenção do controle de placa através da higienização são eficazes em manter a baixa incidência das doenças peri-implantares.

Objective: to guide professionals on the diagnosis, identification, risk factor evaluation, and adequate treatment selection for peri-implant diseases. Material and methods: a literature search was made on the Medline and EBSCO electronic databanks within 1992 and 2013, limited to articles published in the English language. All evidence levels were included (case reports, animal experiments, reviews, and statistical studies in humans). Results: the main etiological agent is still bacterial plaque. However, local and systemic risk factors influence the development of peri-implantitis. The main microorganisms in peri-implant diseases are the same found for periodontitis: gram bacteria and anaerobes. The surgical treatment performed as a single measure did not present satisfactory results; nevertheless, when associated to antibiotics or oral anti-septic products, the infection levels were reduced. The surgical treatment allows for accurate debridement of the peri-implant site and implant surface decontamination, with clinical gains on attachment and bone reconstruction. Conclusion: until the present moment, there is no standard protocol for peri-implant treatment. Prevention of plaque build-up and maintenance through hygiene measures are efficient to reduce the incidence of peri-implant diseases.

Reabilitação imediata em área estética em alvéolo com grande comprometimento ósseo / Immediate rehabilitation of the aesthetic region with alveolar bone loss

As reabilitações em áreas estéticas com defeitos ósseos alveolares são desafios na utilização de implantes dentários. Dessa forma, o objetivo do estudo foi relatar um caso clínico da reabilitação implanto-suportada em alvéolos frescos com parede óssea comprometida, devido à pequena área de ancoragem para a inserção de implantes. No presente caso, o paciente apresentou-se com fratura do elemento dentário 24 associada à perda óssea extensa na face vestibular e reduzida altura óssea para ancoragem superior devido à proximidade com o soalho do seio maxilar, necessitando de reabilitação com implantes osseointegrados, com profissionalização imediata e regeneração óssea guiada (ROG), acompanhado de associação de substituto ósseo e membranas autólogas de fibrina. Após o período de osseointegração, foram realizados procedimentos de moldagem personalizada para a reabilitação final com prótese metalocerâmica. Baseada na metodologia descrita nesse relato de caso é possível notar, após o período de 18 meses de acompanhamento clínico e radiográfico/tomográfico, que não houve sintomatologia dolorosa, infecção, mobilidade do implante e perda óssea peri-implantar acentuada. O paciente apresentou-se satisfeito com relação à estética e função protética.

Dental implant rehabilitation in the aesthetic region with alveolar bone deffects is very challenging. The aim of this study was to present a case report of implantsupported prosthesis in fresh socket with bone wall loss due to reduced area to implant insertion.The patient presented with fracture of tooth 24 associated with extensive bone loss on the vestibular face and reduced bone height for upper anchorage due to the proximity to the maxillary sinus, requiring rehabilitation with dental implants with immediate provisionalization and guided bone regeneration (GBR), followed by bone substitute and autologous fibrin membranes. After osteointegration period, customized casting procedures were performed for final rehabilitation with metal-ceramic prosthesis. Based on the described methodology, pain symptomatology, pain, infection, implant mobility, and marked peri-implant bone loss were not observed during 18 months of clinical and radiographic/tomographic follow-up. The patient was satisfied with both aesthetic and function.

Peri-implantite (Parte I): etiologia, características e diagnóstico / Peri-implantitis: causes, characteristics and diagnosis

A peri-implantite é uma infecção dos tecidos ao redor do implante que resulta na perda do osso de suporte. Alguns fatores locais e sistêmicos influenciam na evolução desta doença e seu tratamento pode ser cirúrgico ou não. O objetivo desta revisão bibliográfica foi orientar os profissionais a diagnosticar as doenças peri-implantares, conhecer suas características e avaliar os fatores de risco. O estudo bibliográfico foi realizado utilizando os bancos de dados Medline e Ebsco, no qual o período de referência foi entre 1992 e 2013. A pesquisa foi limitada a artigos completos publicados no idioma inglês. Todos os níveis de evidência foram incluídos, tais como relato de caso, experimentos em animais, revisões bibliográficas e estudos estatísticos com humanos. De acordo com a revisão bibliográfica o principal agente etiológico das doenças peri- implantares ainda é a placa bacteriana, no entanto, fatores de risco sistêmicos e locais influenciam no seu desenvolvimento. Os principais microrganismos presentes nas infecções peri-implantares são os mesmos encontrados na periodontite, ou seja, bactérias gram e anaeróbios. Contudo, nenhuma definição evidente da microbiota associada com a peri-implantite foi estabelecida até o momento, dificultando um diagnóstico mais preciso e a determinação do protocolo de tratamento. O tratamento não cirúrgico isoladamente não apresentou resultados satisfatórios, no entanto, quando combinado com antibiótico oral ou antisséptico reduziu a infecção peri-implantar. O tratamento cirúrgico permite o debridamento exato da área contaminada peri-implantar do implante, o que resulta em ganho de inserção clínica e reconstrução óssea. Até a presente data, nenhum protocolo de tratamento padrão foi definido para peri-implantite.

Peri-implantitis is an infection of the tissues around the dental implant resulting in loss of supporting bone. Many local and systemic factors influence the development of the disease and its treatment can be surgical or non-surgical. The purpose of this literature review is to guide professionals to diagnose peri-implant diseases, knowing their characteristics, assess to risk factors and choosing appropriate treatments for each situation. The literature search was performed using Medline and Ebsco database and the period between 1992 and 2013. The search was limited to full-text articles published in English. All levels of evidence were included such as case report, animal experiments, literature reviews and statistical studies with humans. According to literature review the main etiological agent of peri-implant diseases still is the plaque, however, systemic and local risk factors influence its development. The main present microorganisms in the periimplant infection are the same found in periodontitis such as Gram- and anaerobic bacteria. However, no clear definition of the microbiota associated with the peri-implantitis has been established yet, making a more accurate diagnosis and determination of the treatment protocol. The non-surgical treatment alone did not show satisfactory results, however, when combined with oral antibiotic or antiseptic reduces peri-implant infection. Surgical treatment allows accurate debridement of the peri-implant area, decontamination of the implant surface and results in gain of clinical attachment and bone reconstruction. To date, no standard treatment protocol of peri-implantitis.