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3.
Lancet ; 2(8290): 125-7, 1982 Jul 17.
Article in English | MEDLINE | ID: mdl-6123839

ABSTRACT

10 homosexual men with Kaposi's sarcoma (KS) were studied for evidence of cytomegalovirus (CMV) infection. IgG and IgM antibodies to CMV were detected in 9 out of 9 and in 7 out of 9 of these patients, respectively. CMV was recovered from body secretions or peripheral blood of 7 patients. Viral cultures of KS tumour biopsy specimens were negative in 8 out of 8 patients, but CMV RNA was detected by in-situ hybridisation in 2 out of 3 and CMV antigen(s) by immunofluorescence in 6 out of 9. Normal tissue specimens from 3 KS patients were negative for CMV antigen. These observations suggest an association of CMV with KS.


Subject(s)
Cytomegalovirus Infections/complications , Cytomegalovirus/immunology , Homosexuality , Sarcoma, Kaposi/etiology , Adult , Animals , Antibodies, Viral/analysis , Cytomegalovirus/isolation & purification , Humans , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Male , Middle Aged , RNA, Viral/analysis , Sarcoma, Kaposi/immunology , Tumor Virus Infections/immunology
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