ABSTRACT
The paper summarizes and analyzes the results of complex treatment of patients with malignant tumors performed in the N.N.Petrov Research Institute of Oncology using perfusion technologies. Safety and efficacy data on various chemoperfusion is presented: intraperitoneal chemoperfusion combined with cytoreductive surgery in patients with locally advanced and disseminated gastric cancer, recurrent ovarian cancer and pseudomyxoma peritonei; isolated lung perfusion combined with metastasectomy in patients with lung metastases; isolated limb perfusion with/without cytoreduction in patients with locally advanced skin melanoma and locally advanced soft-tissue sarcoma. The conclusion is made that both intraperitoneal and isolated chemoperfusions are not associated with higher incidence of intra- and postoperative morbidity. However safety of the procedures could be increased through optimizing tactics of surgical procedures prior to chemoperfusions. The use of perfusion technologies provides significant survival advantage in patients who can't benefit from conservative treatment.
Subject(s)
Chemotherapy, Cancer, Regional Perfusion , Neoplasms/mortality , Neoplasms/therapy , Disease-Free Survival , Female , Humans , Male , Survival RateABSTRACT
The data of literature on possibility of the use of perfusion technologies in combined treatment for malignant tumors of different sites are presented. Possible complications during hyperthermic chemoperfusion are discussed and the effectiveness of this method is analyzed.
Subject(s)
Chemotherapy, Cancer, Regional Perfusion/methods , Hyperthermia, Induced , Neoplasms/drug therapy , Female , Humans , Hyperthermia, Induced/adverse effects , Lung Neoplasms/drug therapy , Lung Neoplasms/pathology , Melanoma/drug therapy , Neoplasms/pathology , Ovarian Neoplasms/drug therapy , Pleural Neoplasms/drug therapy , Pleural Neoplasms/secondary , Sarcoma/drug therapy , Skin Neoplasms/drug therapy , Stomach Neoplasms/drug therapy , Treatment OutcomeSubject(s)
Colorectal Neoplasms, Hereditary Nonpolyposis/genetics , Mutation , Adaptor Proteins, Signal Transducing , Carrier Proteins , Cell Transformation, Neoplastic/genetics , Cell Transformation, Neoplastic/metabolism , Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis , Colorectal Neoplasms, Hereditary Nonpolyposis/metabolism , DNA Repair/genetics , Disease Progression , Genomic Instability/genetics , Humans , Microsatellite Repeats/genetics , MutL Protein Homolog 1 , Neoplasm Proteins/genetics , Nuclear ProteinsABSTRACT
In a family consisting of 48 persons with high predisposition to familial stomach cancer (SCr), SCr was diagnosed in 8 persons (I-2; II-1,3,4; III-1,2,3,4). Moreover, one woman (III-8) had bilateral breast cancer and two (proband: IV-1 and her father's cousin: III-10) chronic gastritis. The proband, her father's cousin, his sister (III-11) and the proband's sister (IV-2) were examined clinically and cytogenetically (with the metaphase method on blood lymphocytes with G-banding of chromosome 21: (p12-pter) in 100% of cells on the basis of chromosomal instability; besides, the complex translocation in chromosome 2 in 4% of cells and the increase of q-arm of chromosome 21 was found in 2% of cells. The proband's sister (IV-2) had 3% of cells with polyploidy, the del 1 (p34-pter) in 1% of cells and the del 7 (p21-pter) in 4% of cells. The cytogenetic examination of the proband's uncle (III-10), carried out 3 times, revealed the case of the proband, endomitosis in 2% of cells, polyploidy in 2% of cells and hyperaneuploidy in 4% of cells. His sister (III-11) had 4% of cells with endomitosis, 3% of cells with chromosome and chromatid breaches, an increase of the p-arm of chromosome 21 in 100% of cells and the loss of 7p in 2% of cells. The nature of the phenomenon in chromosome 21 and the translocations in the members of this family is here discussed. The cytogenetic examination is currently ongoing.
