ABSTRACT
Antibiotic resistance and its impact on human microbiome remains a global public health concern. Studies have shown that treatment with antibiotics leads to dramatic changes in composition and function of gut microbiome. This review focuses on the association between antibiotics use and its impact on gut microbiome of adults and children, gut microbiota metabolic interactions and presents the current understanding of the link between human gut microbiome and immune system.
Subject(s)
Gastrointestinal Microbiome , Microbiota , Adult , Anti-Bacterial Agents/therapeutic use , Child , Drug Resistance, Microbial/drug effects , Humans , Immune System/drug effectsABSTRACT
The aim of the study was to evaluate the wound healing properties of the recombinant human angiogenin drug in the gel form on the models of planar musculocutaneous wound and a linear wound. The rats were divided into 3 groups: 1st group - control animals, that did not get any treatment of wounds; 2nd group - experimental, where animals' wound surface was treated with recombinant human angiogenin in a gel medicinal form; and the 3rd group - a comparison group, where animals were treated with "Solcoseryl" drug. The resulted morphology data and the time of complete epithelialization of planar wounds suggest that the human angiogenin drug in gel form has a pronounced wound healing activity. The latter surpasses the studied parameters of the reference drug "Solcoseryl", by contributing to the acceleration of healing process of planar musculocutaneous and linear wounds in rats.
Subject(s)
Ribonuclease, Pancreatic/therapeutic use , Wound Healing/drug effects , Wounds and Injuries/drug therapy , Actihaemyl/therapeutic use , Animals , Gels , Humans , Male , Rats , Recombinant Proteins/therapeutic use , Wounds and Injuries/pathologyABSTRACT
The aim of the study was to assess the hepatoprotective properties of the RNA-containing drug RN-13 on the model of acute CLL4 induced hepatitis in rats. To evaluate hepatoprotective properties of the RNA-containing drug RN-13 42 female rats were used. RN-13 increases the survival rate of animals with acute tetrachloromethane hepatitis. The hepatoprotective properties of RN-13 were confirmed by biochemical and morphological data. RN-13 helps to reduce the activity of alanine aminotransferase, which indicates its ability to limit cytolysis syndrome. Morphological studies confirm the ability of RN-13 to prevent destruction of liver tissue, preserve the radial structure of the hepatic lobes, and limit the development of hydropic and fatty degeneration.
