[The function of palatine tonsils in pathological changes of oral mucosa and the possibilities of immunorehabilitation].

The objective of the present study was to estimate the possibility of using imudon for the treatment of chronic generalized periodontitis (CGP) in the patients presenting with various forms of chronic tonsillitis (CT) based on the results of the study of local immunity of the oropharynx. A total of 92 patients with CGP were divided into 3 groups as follows: those without pathology of palatine tonsils (PT) (group 1), cases with compensated chronic tonsillitis (group 2), and patients with periodontitis and concomitant decompensated form of CT (paratonsilitis). The results of assessment of local immunity (from the analysis of immunocytograms of the PT surface and periodontal pockets along with the data on the immunoglobulin content in mixed saliva samples and blood plasma) give evidence of the specific features of local immune responsiveness depending on the state of palatine tonsils. The changes of local immunity characteristics after the treatment suggest the efficacy of the traditional treatment of chronic generalized periodontitis in the absence of NT pathology and the necessity of its supplementation with imudon herapy in the patients with CGP and compensated form of CT.

[Immune reactions of palatine tonsils in the patients with chronic tonsillitis and the possibilities for their immunological rehabilitation with the use of imudon].

The objective of the present study was to develop a rationale for the application of imudon (a bacterial lysate preparation)in the treatment of the patients presenting with chronic tonsillitis based on the elucidation of characteristics of local immunity in the oropharynx (determined from the results of cytograms, immunoenzyme assays for the quantitation of IgG, sIgA, IgA, and IgM antibodies, and calculation of the relative secretion coefficients). A total of 74 patients with chronic tonsillar pathology (24 children and 50 adults) were available for the observation along with 42 subjects having no tonsillar pathology with concomitant chronic bacterial rhinosinusitis. The control group was constituted by 25 practically healthy subjects. It was shown that the local application of imudon in the patients with the preserved function of palatine tonsils (in the absence of symptoms of chronic inflammation) produces the adequate response of the humoral and cellular immunity systems. In the patients with the simple form of chronic tonsillitis imudon therapy ensured statistically significant activation of congenital immunity including the phagocyte function and a tendency toward normalization of antibody formation. It is concluded that alteration of the function of palatine tonsils in the patients presenting with the toxico-allergic form (ТАФ-2) of chronic tonsillitis implies the necessity of surgical treatment (tonsillectomy).