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Pathologe ; 34(4): 343-6, 2013 Jul.
Article in German | MEDLINE | ID: mdl-23306533

ABSTRACT

Within a few months a 31-year-old female patient was diagnosed with a psammomatous melanotic schwannoma, an atrial myxoma and microfollicular adenomas in both thyroid lobes. Therefore, sufficient diagnostic criteria of a Carney complex were fulfilled. The Carney complex is an inherited autosomal dominant disorder with highly variable phenotypes, which was initially described by Carney in 1985 as a complex of myxomas, spotty skin pigmentation and endocrine overactivity. Pathologists should consider this differential diagnosis in reports when confronted with a psammomatous melanotic schwannoma.


Subject(s)
Adenoma/pathology , Carney Complex/pathology , Heart Neoplasms/pathology , Myxoma/pathology , Neoplasms, Multiple Primary/pathology , Neurilemmoma/pathology , Thyroid Neoplasms/pathology , Adenoma/genetics , Adult , Carney Complex/genetics , Cyclic AMP-Dependent Protein Kinase RIalpha Subunit/genetics , DNA Mutational Analysis , Diagnosis, Differential , Female , Head and Neck Neoplasms/genetics , Head and Neck Neoplasms/pathology , Heart Atria/pathology , Heart Neoplasms/genetics , Humans , Myxoma/genetics , Neoplasms, Multiple Primary/genetics , Neurilemmoma/genetics , Phenotype , Signal Transduction/genetics , Thyroid Gland/pathology , Thyroid Neoplasms/genetics
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