Do large-scale agricultural entities achieve higher livelihood levels and better environmental outcomes than small households? Evidence from rural China.

There is an ongoing debate about the type or scale of agriculture that should be most encouraged. This study explores the differences in livelihood levels and outcomes between new agricultural business entities (NABEs) and traditional small households. We applied the analytical tools of a sustainable livelihood framework and a multiple linear regression model to describe the determinants of livelihood outcomes of 105 NABEs and 119 traditional small households in two typical areas around the Sichuan Basin in China. The results show that the overall livelihood level of NABEs is 1.40 times higher than traditional small households. NABEs with a mixed livelihood strategy of both planting and breeding have the highest livelihood level, followed by planting NABEs and breeding NABEs. About 3.13% of all agricultural entities are at risk of falling into poverty; the greater risk levels are associated with the subsidized households (30.00%), pure farmers (12.50%), and part-time farming households (1.69%). NABEs in the study area are verified to use 2.06 times more pesticide and herbicide inputs compared to traditional small households. Education level, technical training, financial accessibility, and the connection with professional cooperatives are common factors influencing the livelihood levels of the two groups of agricultural entities. Livelihood levels of NABEs are also significantly influenced by the age of NABE leaders, planting area per capita, and agricultural insurance. Based on these results, the study proposes policy interventions that are most appropriate for achieving higher livelihood levels among both NABEs and small households. Although the mixed type of NABEs and non-farming households are recognized as being better agricultural entity types for poverty alleviation, we recommend a balance between fostering NABEs and maintaining traditional small households; guidance related to green agriculture production for NABEs is also urgently needed.

Moderate operation scales of agricultural land under the greenhouse and open-field production modes based on DEA model in mountainous areas of southwest China.

The identification of the moderate scale of agricultural land was recognized as one of the key measures promoting sustainable agriculture development. However, due to the research gap in mountainous areas, new agricultural business entities (NABE) in these areas usually either refer to the plain area or simply pursue large scale, resulting in low production efficiency and even posing a threat to their sustainable survival. In this study, the Data Envelopment Analysis (DEA) model and Tobit regression model tools were employed to quantitatively reveal the moderate scale and key driving factors of agricultural land under the scale operation modes of greenhouse and open-field types. It was based on 154 NABE questionnaires in the mountainous areas around the Sichuan Basin in China, where NABEs are flourishing. The findings show an approximately "inverted U-shaped" curve relationship between NABE's production efficiency and their planting scale. The primary reason for the failure of NABE to achieve an overall high level of production efficiency is scale inefficiency. The optimal scale intervals for the greenhouse and open-field types of scale operation modes are 3.0-4.3 ha and 3.3-5.0 ha, respectively. Business entities' age, land circulation scale, land rent, and agricultural insurance are common factors that influence the scale efficiencies of both the greenhouse and open-field types. Accordingly, policy interventions regarding the guidance of moderate-scale operation of agricultural land are proposed for achieving the dual goal of cultivating NABE and implementing the Rural Revitalization Strategy in mountainous areas of China. While contributing to the knowledge on scale efficiency of agricultural land, this research also enlightens the practice of policy-making targeted to the sustainable development of agricultural industry led by NABE worldwide.

Salidroside attenuates HALI via IL-17A-mediated ferroptosis of alveolar epithelial cells by regulating Act1-TRAF6-p38 MAPK pathway.

BACKGROUND AND PURPOSE: Hyperoxia-induced acute lung injury (HALI) is a critical life-threatening disorder characterized by severe infiltration immune cells and death of type II alveolar epithelial cells (AECII). However, little is known about the relations between immune cells and AECII in HALI. IL-17A is a pro-inflammatory cytokine mainly secreted by Th17 cells, contributing to the pathogenesis of various inflammatory diseases. The present study investigated the role of IL-17A in cell-cell communication between immune cells and AECII in HALI, and explored the therapeutic effect of salidroside (Sal, a natural anti-inflammatory agents) on HALI. METHODS: Mice with HALI were induced by exposure to hyperoxia over 90% for 12 h, 24 h, 48 h or 72 h, and the optimal timing was detected by H&E and Masson staining. Ferroptosis was confirmed by detecting the levels of MDA, Fe2+ and GPX4, and the morphological alterations of AECII under transmission electron microscopy. The expression of pro-inflammatory cytokine, including IL-6, TGF-ß1, IL-17A and IL-17A receptor (IL-17RA) were measured by Western blotting and immunohistochemical stanning. The ferroptosis-related Act1/TRAF6/p38 MAPK pathway was detected by Western blotting. The role of pro-inflammatory cytokine IL-17A for AECII ferroptosis, and the effect of Sal on HALI were investigated by administration of Y-320 (IL-17 inhibitor) and Sal respectively 3 days before mice exposed to hyperoxia. RESULTS: Mice exposed to hyperoxia for 24 h suffered sufficient HALI with inflammatory cell infiltration and collagen deposition, and exhibited features of ferroptosis under TME. Meanwhile, compared with sham mice, mice exposed to hyperoxia showed down-regulation of GPX4, and up-regulation of IL-6, TGF-ß1, IL-17A, IL-17RA, Act1, TRAF6, p38 MAPK and p-p38 MAPK. Moreover, inhibition of IL-17A with Y-320 or administration with Sal could reverse the effect caused by hyperoxia respectively. CONCLUSIONS: IL-17A is associated with immune cells infiltration in HALI, and contributes to ferroptosis of AECII that related to Act1/TRAF6/p38 MAPK pathway. Additionally, Sal protects against HALI throughout the whole pathogenic process. Video Abstract.

Oxygen inhalation has been widely used in the treatment of some diseases caused by hypoxia. This often leads people to mistakenly believe that oxygen inhalation is beneficial without harm. However, long-term high concentration oxygen inhalation will cause serious harm to the human body, sometimes even fatal. Hyperoxia causes lung cells to secrete proinflammatory factors, which promote the differentiation of infiltrated immune cells. The differentiated immune cells in turn act on lung cells and lead to their death. In short, this process is a vicious circle. Our research explores this process and is committed to finding a drug to reduce the damage of hyperoxia to the lungs when oxygen must be inhaled.