Persistent warm-eddy transport to Antarctic ice shelves driven by enhanced summer westerlies.

The offshore ocean heat supplied to the Antarctic continental shelves by warm eddies has the potential to greatly impact the melting rates of ice shelves and subsequent global sea level rise. While featured in modeling and some observational studies, the processes around how these warm eddies form and overcome the dynamic sub-surface barrier of the Antarctic Slope Front over the upper continental slope has not yet been clarified. Here we report on the detailed observations of persistent eddies carrying warm modified Circumpolar Deep Water (CDW) onto the continental shelf of Prydz Bay, East Antarctica, using subsurface mooring and hydrographic section data from 2013-2015. We show the warm-eddy transport is most active when the summer westerlies strengthen, which promotes the upwelling of CDW and initiates eddy formation and intrusions. Our study highlights the important role of warm eddies in the melting of Antarctica's ice shelves, both now and into the future.

FOXJ2 Inhibits the Proliferation, Migration and Epithelial-Mesenchymal Transition of Prostate Carcinoma Cells.

OBJECTIVE: Forkhead box J2 (FOXJ2) which belongs to FOX transcription factors family has been regarded as diagnostic, prognostic biomarker and therapeutic target of various cancers. The aim of this study is to investigate the role of FOXJ2 in prostate carcinoma. METHODS: Western blot and qRT-PCR were applied to detect expression of FOXJ2 in prostate carcinoma cells. MTT and colony formation assays were used to detect cell proliferation. Cell migration and invasion were assessed by wound healing and transwell assays. RESULTS: FOXJ2 was down-regulated in primary prostate carcinoma tissues compared to the normal tissues based on the TCGA database. Prostate carcinoma cells also showed lower expression of FOXJ2 than normal prostate cell line (RWPE-1). pcDNA-mediated ectopical expression of FOXJ2 increased cell viability of prostate carcinoma cells, and promoted the proliferation, migration and invasion. Over-expression of FOXJ2 enhanced protein expression of E-cadherin, reduced N-cadherin, vimentin and fibronectin in the prostate carcinoma cells. Protein expression of Notch 1, Jagged-1, and Hes 1 were up-regulated in prostate carcinoma cells by over-expression of FOXJ2. CONCLUSIONS: FOXJ2 inhibited the proliferation, migration and epithelial-mesenchymal transition (EMT) of prostate carcinoma cells through inactivation of Jagged-1/Notch-1/Hes-1 pathway.

The Effect of PACS in Breast Tumor Diagnosis Based on Numerical Analysis.

The incidence and mortality rates are increasing year by year, and the incidence of the disease is gradually becoming younger. The purpose of this study was to investigate the clinical diagnostic value of PACS in breast tumor patients. Methods. 20 patients with breast tumor diagnosed by PACS were selected for the study, and the diagnosis was confirmed by pathological puncture or surgery. Results. The detection rates of breast tumor by MRI and CT were 94.44% and 96.67%, the sensitivities were 18.82% breast tumor and 96.67%, and the specificities were 53.84% and 54.54%, with no statistically significant difference (P > 0.05). There was no statistically significant difference in the detection rate of invasive lobular carcinoma (LDC) and PACS (P > 0.05). Conclusion. PACS has a greater detection rate for breast tumor and offers some diagnostic usefulness in diagnosing malignant breast tumor. The detection rate of breast tumors can be increased by selecting the most appropriate diagnostic tool for the patient's current circumstances.

Suprapubic-assisted laparoendoscopic single-site surgery versus standard laparoscopic nephrectomy: A propensity score-based analysis.

OBJECTIVES: To compare suprapubic-assisted laparoendoscopic single-site surgery nephrectomy with standard laparoscopic nephrectomy. METHODS: A retrospective case-control study comparing three surgeons' experience with 122 suprapubic-assisted laparoendoscopic single-site surgery nephrectomy and 107 standard laparoscopic nephrectomy was carried out. Operative time, estimated blood loss, intraoperative complications, intraoperative conversion, postoperative bowel recovery, postoperative analgesics, postoperative visual analog pain scale score, postoperative length of stay, days before going back to work, postoperative complications and Patient Scar Assessment Questionnaire were compared after propensity score matching. RESULTS: A total of 97 matched pairs were obtained after propensity score matching. There were no statistically significant differences between the suprapubic-assisted laparoendoscopic single-site surgery nephrectomy and standard laparoscopic nephrectomy groups with respect to operative time, estimated blood loss, intraoperative complications, intraoperative conversion, postoperative bowel recovery, length of stay and postoperative complications. Suprapubic-assisted laparoendoscopic single-site surgery nephrectomy group had decreased postoperative analgesics (20.9 vs 23.5, P = 0.04), visual analog pain scale score at 24 h (4.28 vs 5.28, P = 0.000), visual analog pain scale score at discharge (1.01 vs 1.47, P = 0.000), days before going back to work (28.4 vs 31.9, P = 0.000) and Patient Scar Assessment Questionnaire score (34.0 vs 42.0, P = 0.000), compared with the standard laparoscopic nephrectomy group. CONCLUSIONS: Suprapubic-assisted laparoendoscopic single-site surgery nephrectomy and standard laparoscopic nephrectomy are equivalent in terms of the safety and efficacy. However, suprapubic-assisted laparoendoscopic single-site surgery nephrectomy confers less postoperative pain, fewer days before going back to work and better cosmetic result when compared with standard laparoscopic nephrectomy.