ABSTRACT
Neurodegenerative diseases involve the progressive dysfunction and loss of neurons in the central nervous system and thus present a significant challenge due to the absence of effective therapies for halting or reversing their progression. Based on the characteristics of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), which have prolonged incubation periods and protracted courses, exploring non-invasive physical therapy methods is essential for alleviating such diseases and ensuring that patients have an improved quality of life. Photobiomodulation (PBM) uses red and infrared light for therapeutic benefits and functions by stimulating, healing, regenerating, and protecting organizations at risk of injury, degradation, or death. Over the last two decades, PBM has gained widespread recognition as a non-invasive physical therapy method, showing efficacy in pain relief, anti-inflammatory responses, and tissue regeneration. Its application has expanded into the fields of neurology and psychiatry, where extensive research has been conducted. This paper presents a review and evaluation of studies investigating PBM in neurodegenerative diseases, with a specific emphasis on recent applications in AD and PD treatment for both animal and human subjects. Molecular mechanisms related to neuron damage and cognitive impairment are scrutinized, offering valuable insights into PBM's potential as a non-invasive therapeutic strategy.
Subject(s)
Alzheimer Disease , Low-Level Light Therapy , Neurodegenerative Diseases , Parkinson Disease , Animals , Humans , Neurodegenerative Diseases/radiotherapy , Low-Level Light Therapy/methods , Quality of Life , Alzheimer Disease/drug therapy , Parkinson Disease/drug therapyABSTRACT
The selective functionalization of ubiquitous but inert C-H bonds is highly appealing in synthetic chemistry, but the direct transformation of hydrocarbons lacking directing groups into high-value chiral molecules remains a formidable challenge. Herein, we develop an enantioselective C(sp3)-H functionalization of undirected oxacycles via photo-HAT/nickel dual catalysis. This protocol provides a practical platform for the rapid construction of high-value and enantiomerically enriched oxacycles directly from simple and abundant hydrocarbon feedstocks. The synthetic utility of this strategy is further demonstrated in the late-stage functionalization of natural products and the synthesis of many pharmaceutically relevant molecules. Experimental and density functional theory calculation studies provide detailed insights into the mechanism and the origin of enantioselectivity for the asymmetric C(sp3)-H functionalization.