An integrated simulation-optimization approach for combined allocation of water quantity and quality under multiple uncertainties.

Multiple uncertainties such as water quality processes, streamflow randomness affected by climate change, indicators' interrelation, and socio-economic development have brought significant risks in managing water quantity and quality (WQQ) for river basins. This research developed an integrated simulation-optimization modeling approach (ISMA) to tackle multiple uncertainties simultaneously. This approach combined water quality analysis simulation programming, Markov-Chain, generalized likelihood uncertainty estimation, and interval two-stage left-hand-side chance-constrained joint-probabilistic programming into an integration nonlinear modeling framework. A case study of multiple water intake projects in the Downstream and Delta of Dongjiang River Basin was used to demonstrate the proposed model. Results reveal that ISMA helps predict the trend of water quality changes and quantitatively analyze the interaction between WQQ. As the joint probability level increases, under strict water quality scenario system benefits would increase [3.23, 5.90] × 109 Yuan, comprehensive water scarcity based on quantity and quality would decrease [782.24, 945.82] × 106 m3, with an increase in water allocation and a decrease in pollutant generation. Compared to the deterministic and water quantity model, it allocates water efficiently and quantifies more economic losses and water scarcity. Therefore, this research has significant implications for improving water quality in basins, balancing the benefits and risks of water quality violations, and stabilizing socio-economic development.

Coupling and decoupling of soil carbon and nutrients cycles at different salinity levels in a mangrove wetland: Insights from CUE and enzymatic stoichiometry.

Soil carbon (C), nitrogen (N), and phosphorus (P) cycling, in conjunction with microbial metabolism, varies significantly with salinity in coastal areas. However, microbial metabolism limitation on salinity levels has received limited attention. Based on soil microbial carbon use efficiency and enzymatic stoichiometry, microbial nutrient limitation characteristics of soil microbial communities in different salinity levels (4.45 mS·cm-1 - 17.25 mS·cm-1) in a subtropical mangrove wetland were investigated. Compared to low-salinity levels, the activity of soil C-acquiring enzyme activities, enzymatic C:N ratios and enzymatic C:P ratios decreased with medium salinity levels and high salinity levels. Soil microbial metabolism was primarily constrained by C and N at different salinity levels. Boosted regression tree analysis revealed that abiotic factors had the greatest influence on C and N limitation of microbial metabolism at different salinity levels. This study underscores the significance of salinity in microbial metabolic processes and enhances our understanding of how future salinity changes induced by rising sea levels will affect soil carbon and nutrient cycling in coastal wetlands.

MicroRNA-22-3p alleviates atherosclerosis by mediating macrophage M2 polarization as well as inhibiting NLRP3 activation.

OBJECTIVE: MicroRNA (miR)-22-3p is expressed in atherosclerosis (AS), but its function and regulatory mechanisms remain unclear. Therefore, the effects of miR-22-3p in AS were assessed in this study. METHODS: MiR-22-3p expression was assessed in AS, and miR-22-3p target genes were predicted using sequencing transcriptomics. The effect of miR-22-3p agomir on atherosclerotic lesions in an AS mouse model were determined by Oil red O, Masson's, and sirius red staining, and by anti-smooth muscle actin and macrophage antigen-3 immunostaining. Gene expression in AS was evaluated by western blot and immunofluorescence. RESULTS: MiR-22-3p was expressed in AS and control samples (32.5% and 33.9% levels, respectively, relative to total miRNA among six highly expressed miRNAs). In the mouse model of AS, miR-22-3p agomir significantly reduced lipid deposition, proliferation of aortic collagen fibres, and macrophage content. Additionally, inducible nitric oxide synthase, interleukin-6, and tumour necrosis factor-α levels were significantly reduced, and levels of arginase 1 and CD206 were significantly enhanced. MiR-22-3p was found to target janus kinase 1(JAK1), and significantly inhibited the activation of NLR family pyrin domain containing 3 (NLRP3) and JAK1 in mice. CONCLUSIONS: MiR-22-3p appears to reduce the inflammatory response in AS, which might be achieved by inducing the M2 macrophage phenotype and suppressing NLRP3 activation via JAK1.

An improved approach for evaluating landscape ecological risks and exploring its coupling coordination with ecosystem services.

The rapid urbanization has accelerated the destruction of regional ecosystems, triggering ecological risks and threatening sustainable development. Landscape ecological risk (LER) evaluation is an effective tool to mitigate such negative impacts. However, the existing evaluation systems exhibit certain subjectivity. Therefore, an improved LER evaluation method was proposed, which incorporates ecosystem services (ESs) to characterize landscape vulnerability. The method was validated using the Pearl River Delta urban agglomeration (PRDUA) as the study area. The results showed that the optimal grain size and extent for landscape pattern analysis in the PRDUA were determined to be 150 m and 6km × 6 km, respectively. The comparison results with the traditional LER evaluation method demonstrated the improved method's superior rationality and reliability. The hotspot analysis based on the Getis-Ord Gi* method revealed that the hotspots of LER were mainly concentrated in the densely populated areas of the south-central region of the PRDUA. The coupling coordination degree (CCD) between LERs and ESs showed four different levels of development in both temporal and spatial dimensions, generally dominated by moderately balanced development and lagging ESs, reflecting the unbalanced ecological environment and socio-economic development of the PRDUA. It is recommended that the ecosystems in the PRDUA be managed and protected separately according to the delineated Ecological Protection Area (EPA), Urban Built-up Area (UBA), and Urban Ecological Boundary Area (UEBA). This study can provide an important reference for regional ecosystem conservation and management.

Correlation study on the relationship between dyslipidemia and carotid intima-media thickness in patients with diabetes mellitus.

Objective: To investigate the correlation between dyslipidemia and carotid intima-media thickness (IMT) in patients with diabetes mellitus. Methods: A descriptive research design was adopted in this study. One hundred and twenty patients with Type-2 diabetes mellitus who were admitted to the physical examination center of The Fourth Hospital of Hebei Medical University from June 2020 to June 2021 for physical examination were recruited to the experimental group. The 120 patients were divided into three groups according to carotid IMT: normal group, thickened group, and plaque group. Forty healthy people who underwent a physical examination during the same period were recruited as the control group. The differences in IMT in various parts of the experimental group and the control group and the differences in blood lipid indexes were compared and analyzed. In addition, the correlation between mean IMT of bilateral common carotid arteries and blood lipid levels in normal, thickened and plaque groups was compared and analyzed. Results: The intima-media thicknesses of the internal carotid artery and bilateral common carotid arteries of the patients in the experimental group were significantly thicker than those in the healthy control group, the levels of TC, TG and LDL were higher than those in the control group, while the level of HDL was lower than that in the control group, with a statistically significant difference (p=0.00). The levels of fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), TG, TC and LDL were positively correlated with the mean IMT of bilateral common carotid arteries (p<0.05), while the level of HDL was negatively correlated with the mean IMT of bilateral common carotid arteries (p<0.05). Conclusion: Dyslipidemia and glucose metabolism in patients with Type-2 diabetes mellitus have a close bearing on carotid IMT. Clinically, patients with Type-2 diabetes mellitus can be judged by monitoring carotid IMT for dyslipidemia, atherosclerosis and other related complications.

A bi-level multi-objective programming model for water resources management under compound uncertainties in Dongjiang River Basin, Greater Bay Area of China.

To facilitate regional water resources allocation, an integrated bi-level multi-objective programming (IBMP) model with dual random fuzzy variables was developed in this research The proposed model was derived through incorporating dual random fuzzy variables, multi-objective programming, and interval parameter programming within a bi-level optimization framework. This approach improved upon the previous bi-level programming methods and had two advantages. Firstly, it was capable of reflecting tradeoffs among multiple conflict preferences for water related bi-level hierarchical decision-making processes. Secondly, random fuzzy variables were used to tackle the dual uncertainties in both sides of the constraints, which were characterize as probability density functions and discrete intervals. Then, a real-world water resources planning problem was employed for illustrating feasibility of the application of IBMP model in Dongjiang river watershed of south China. Results reflected the alternative decisions for water allocation schemes under a set of probability levels and fuzzy α - cut levels, which can support in-depth analysis of tradeoffs among multiple levels and objective values. Moreover, modeling comparison analysis was undertaken to illustrate the performances of the proposed model.

Visualization and Analysis of Mapping Knowledge Domains for Food Waste Studies.

Food waste and loss is a global issue involving ethics, society, the environment, and the economy. However, there is a lack of systematic and visual scientific knowledge and graph methods to study the precedents of this field's development over time. The article is based on the scientific knowledge graph research of articles published in the past 22 years to review the latest food waste research developments. The study will be conducted from the following perspectives: country/region, institution, author, journal, keyword co-occurrence, and article co-citation. It turns out that in the past eight years, food waste research has grown rapidly. A total of 8298 research articles have been published in 8064 journals and 176 Web of Science (WOS) subject categories. Research shows in the past 20 years. The main research hotspots were anaerobic digestion, biogas production, composting, biological hydrogen production, and innovation in system management methods. In the future, efficient and multitask biological value-added conversion technology, systematization of food-supply-chain decision-making aid models, and research on differences in management strategies may become the frontiers of research.