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1.
Immun Inflamm Dis ; 11(11): e1094, 2023 Nov.
Article in English | MEDLINE | ID: mdl-38018585

ABSTRACT

OBJECTIVE: Amiodarone (AM) is a drug commonly used in patients with ventricular arrhythmias. It can damage vascular endothelial cells and easily cause phlebitis. At present, the prevention and treatment of phlebitis induced by the use of AM is not clear due to the lack of corresponding primary research. Isoliquiritigenin (ISL) has an anti-inflammatory effect, but until now, has not been explored much in the field of research in primary care nursing. The purpose of this study is to investigate the efficacy and mechanism of action of ISL in treating phlebitis induced by AM. METHODS: In our study, we used human umbilical vein endothelial cells (HUVECs) that were divided into three groups: the NC group (normal), the AM group (AM 30 µmol/L for 24 h), and the ISL pretreatment group (isoliquiritigenin 10 µmol/L after 1 h of pretreatment with amiodarone for 24 h). We used CCK-8 to detect cell proliferation, cell scratch assay to detect the migration capability of cells, flow cytometry to measure apoptosis, angiogenesis assay to check the total length and total branches of angiogenesis, and PCR and WB to detect the expression of PCNA, casepase-3, and VEGFA. WB was used to detect NF-κBp65 and p-NF-κBp65 expression. RESULTS: Compared with the AM group, the ISL pretreatment promoted cell proliferation and migration, inhibited cell apoptosis, increased the total length and total branches of angiogenesis, and downregulated p-NF-κBp65 expression. CONCLUSION: ISL shows promise in the prevention and treatment of clinical phlebitis and can be used as a potential therapeutic drug to prevent phlebitis.


Subject(s)
Amiodarone , Chalcones , Phlebitis , Humans , Human Umbilical Vein Endothelial Cells , Amiodarone/toxicity , Chalcones/pharmacology
2.
BMC Ophthalmol ; 22(1): 401, 2022 Oct 07.
Article in English | MEDLINE | ID: mdl-36207670

ABSTRACT

BACKGROUND: High-intensity focused ultrasound cyclo-plasty (UCP) is a recently developed glaucoma surgery. This study collected and analysed the clinical data of patients who underwent UCP to observe the efficacy and safety of this surgery in Chinese glaucoma patients. METHODS: This was a retrospective study. The clinical data of all the patients who underwent UCP at Affiliated Foshan Hospital, Southern Medical University, were collected and analysed to evaluate the efficacy and safety of UCP. The main outcome measure was intraocular pressure, and the secondary outcome measures were best corrected visual acuity (logMAR) and complications. RESULTS: Fifty-eight patients (61 eyes) were recruited for this study. IOP was dramatically decreased during the 12 months after UCP (p<0.05). The median IOP reduction during the 18 months post-procedure was more than 30%. The greatest reduction was at 1 month post-UCP (60.86%). The qualified success rate was more than 60% during the 18-month follow-up (Fig. 1). Poor follow up was found after 6-month post-UCP. The highest success rate was obtained at 7 days post-UCP (94.55%). No statistically significant decrease in BCVA in the vison group was observed at the follow-up visits, except for 1 day post-UCP. There was a statistically significant reduction in the use of IOP lowering medications during the 6 months post-UCP. No severe complications occurred. CONCLUSION: UCP is a safe and effective procedure for primary and refractive glaucoma at least during the 6 months post-UCP procedure. Studies with longer follow-up time and better follow up are needed to further confirm the long-term efficacy and safety of UCP in Chinese glaucoma patients.


Subject(s)
Glaucoma , High-Intensity Focused Ultrasound Ablation , Ciliary Body/surgery , Follow-Up Studies , Glaucoma/surgery , High-Intensity Focused Ultrasound Ablation/methods , Humans , Intraocular Pressure , Retrospective Studies , Treatment Outcome
3.
BMC Ophthalmol ; 22(1): 339, 2022 Aug 10.
Article in English | MEDLINE | ID: mdl-35948955

ABSTRACT

BACKGROUND: Optical coherence tomography angiography (OCTA) is a novel technology that provides a noninvasive, dye-less method to visualize the blood vessels of the retina. In the present study, we investigate macular microvascular density and the correlation of ocular and demographic factors using OCTA in Posner-Schlossman syndrome (PSS) patients. METHODS: This is a prospective observational study. All PSS patients and age- and sex-matched healthy subjects underwent complete ophthalmologic examination, and RE, BCVA, IOP, CCT, AL, CMT, GCIPI, RNFL, C/D ratio were recorded. The whole-image vessel density (wiVD) and whole-image perfusion density (wiPD), three-circle (1 mm central ring, 3 mm inner ring, 6 mm outer ring), and four-quadrant segmental VD and PD were calculated. RESULTS: Seventeen PSS patients and 17 healthy subjects were enrolled in this study. The mean age was 42.65 ± 11.22 years in PSS patients and 42.71 ± 10.50 years in healthy controls. IOP, CCT, and C/D ratio were higher in PSS-attacked eyes, and BCVA, OPP and RNFL thickness was lower than those in the fellow eyes (p < 0.05). BCVA and OPP were improved in the PSS-attacked eyes in intermittent period (p < 0.05). The wiVD and wiPD were lower in the PSS-affected eyes than in the fellow eyes and in the control eyes in the PSS-attacked period (p < 0.05). All segmental VD and PD was lower in the PSS affected eyes than in the healthy control eyes (p < 0.05). In intermittent period, the wiVD and wiPD were lower in the PSS-affected eyes than in the fellow eyes (p < 0.05). Age, CCT, and SSI were associated with macular wiVD and wiPD in PSS attacked period. Age and CCT were associated with macular wiVD and wiPD in PSS intermittent period. CONCLUSION: Decreased macular superficial VD and PD was found in patients with Posner-Schlossman syndrome in attacked period and in remission. Macular wiVD and wiPD were associated with age, CCT and SSI in PSS patients.


Subject(s)
Glaucoma, Open-Angle , Optic Disk , Adult , Fluorescein Angiography/methods , Glaucoma, Open-Angle/diagnosis , Humans , Intraocular Pressure , Microvascular Density , Middle Aged , Nerve Fibers , Optic Disk/blood supply , Retinal Ganglion Cells , Retinal Vessels/diagnostic imaging , Tomography, Optical Coherence/methods , Visual Field Tests , Visual Fields
4.
J Inflamm Res ; 15: 205-215, 2022.
Article in English | MEDLINE | ID: mdl-35046695

ABSTRACT

OBJECTIVE: To study the limit time of phlebitis caused by continuous infusion of KabivenTM Pl and TNA (KabivenTM Pl+ alanyl glutamine + potassium aspartate) through a peripheral vein, and to provide a reference for clinical formulation of preventive measures for phlebitis. METHODS: White rabbits (n = 72) were randomly divided into three groups: group A (Normal saline), group B (Kabiven™ Pl), and group C (TNA). Blood was collected from the ear margin vein before administration and after three hours, four hours, five hours, and six hours of administration. CRP and TNF-ɑ were measured by enzyme-linked immunosorbent assay. Hematoxylin and eosin staining and immunohistochemical staining were performed on tissue samples taken from the insertion point of the indwelling needle, the tip of the indwelling needle, and 1 cm from the tip of the indwelling needle, closer to the heart, to analyze early pathological changes in blood vessels. RESULTS: (1) There were no visible inflammatory symptoms in groups A, B, or C within 6 hours. (2) Four hours after starting intravenous administration, the levels of inflammatory markers in groups B and C were higher than in group A, and (3) the degree of inflammatory cell infiltration in groups B and C was more severe than in group A. (4) In all groups, the inflammatory reaction at the tip of the indwelling needle was more severe than at the other two sites. CONCLUSION: When the emulsions TNA and Kabiven™ Pl are infused through a peripheral vein, (1) four hours may be considered as the maximum time for continuous intravenous infusion in the same vein before inflammatory changes become evident, and (2) systematic assessment of the tip of the indwelling needle should be considered for inclusion in the nursing plan for phlebitis monitorings.

5.
J Anal Test ; 5(4): 314-326, 2021.
Article in English | MEDLINE | ID: mdl-34631199

ABSTRACT

The outbreak of severe pneumonia at the end of 2019 was proved to be caused by the SARS-CoV-2 virus spreading out the world. And COVID-19 spread rapidly through a terrible transmission way by human-to-human, which led to many suspected cases waiting to be diagnosed and huge daily samples needed to be tested by an effective and rapid detection method. With an increasing number of COVID-19 infections, medical pressure is severe. Therefore, more efficient and accurate diagnosis methods were keen urgently established. In this review, we summarized several methods that can rapidly and sensitively identify COVID-19; some of them are widely used as the diagnostic techniques for SARS-CoV-2 in various countries, some diagnostic technologies refer to SARS (Severe Acute Respiratory Syndrome) or/and MERS (Middle East Respiratory Syndrome) detection, which may provide potential diagnosis ideas.

6.
Shanghai Kou Qiang Yi Xue ; 23(5): 539-42, 2014 Oct.
Article in Chinese | MEDLINE | ID: mdl-25643428

ABSTRACT

PURPOSE: To investigate the ability of composite graft of osteoblasts and HAP-GEL scaffolds to repair cranial bone defect. METHODS: HAP-GEL and osteoblasts were co-cultured. The rabbit cranial parietal bone defect models were established. HAP-GEL scaffolds and osteoblasts were implanted into the cranial bone defect with blank defect as negative control, autologous skull as positive control. After 4,8,12 weeks, the result was evaluated by gross inspection, three-dimensional computed tomographic scanning and histological examination, respectively. RESULTS: After 4, 8, 12 weeks, blank defects displayed significantly radiolucent area, HAP-GEL with osteoblasts and autologous skull restoration showed high density area, the edges were slightly blur. With time going by, part of the scaffolds were absorbed, and the new bone trabecular was observed in histological examination. In the control groups, only fibrous tissues were observed in the defect region, there was no new bone formation. CONCLUSIONS: the engineering bone constructed by osteoblasts and HAP-GEL scaffold can be applied to repair bone defect.


Subject(s)
Bone Regeneration , Tissue Engineering , Animals , Osteoblasts , Rabbits , Skull , Wound Healing
7.
Invest Ophthalmol Vis Sci ; 50(5): 2319-27, 2009 May.
Article in English | MEDLINE | ID: mdl-19011009

ABSTRACT

PURPOSE: This study was designed to elucidate the role of inflammatory process in diabetic retinopathy and to investigate the effect of baicalein treatment on diabetic rat. METHODS: Retinal microglial cells were identified with CD11b antibody, and retinal Müller cells were identified with glial fibrillary acidic protein (GFAP). The gene expression of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha, and IL-1beta was examined by quantitative real-time PCR. The expression of GFAP and vascular endothelial growth factor (VEGF) was examined by quantitative real-time PCR, immunohistochemistry, and Western blot analysis. Vascular permeability was measured in vivo by bovine serum albumin conjugated with FITC. Baicalein was given by oral administration (150 mg/kg/d) with an animal feeding needle beginning 5 days after streptozotocin (STZ) injection. RESULTS: By 24 weeks after onset of diabetes, microglial cells were activated and proliferated, and Müller cells upregulated their GFAP and VEGF expression. Pro-inflammatory factors, including IL-18, TNF-alpha, and IL-1beta, were significantly upregulated. Obvious vascular leakage and abnormality were demonstrated, and ganglion cell loss was significant. Baicalein treatment ameliorated diabetes-induced microglial activation and pro-inflammatory expression, reduced the GFAP and VEGF expression from Müller cells, and significantly reduced vascular abnormality and ganglion cell loss within the retina. CONCLUSIONS: Inflammatory process, characterized by microglial activation and Müller cells dysfunction, was implicated in STZ-induced diabetic retinopathy. Baicalein treatment ameliorated inflammatory process, and therefore inhibited vascular abnormality and neuron loss in diabetic retinas.


Subject(s)
Anti-Inflammatory Agents/therapeutic use , Diabetes Mellitus, Experimental/drug therapy , Diabetic Retinopathy/drug therapy , Flavanones/therapeutic use , Microglia/drug effects , Retinal Neurons/drug effects , Retinitis/drug therapy , Administration, Oral , Animals , Blood Glucose/analysis , Blood-Retinal Barrier/drug effects , Blotting, Western , CD11b Antigen/metabolism , Capillary Permeability/drug effects , Diabetic Retinopathy/metabolism , Diabetic Retinopathy/pathology , Female , Fluorescent Antibody Technique, Indirect , Glial Fibrillary Acidic Protein/metabolism , Interleukin-18/genetics , Interleukin-1beta/genetics , Microglia/metabolism , Microglia/pathology , RNA, Messenger/metabolism , Rats , Rats, Sprague-Dawley , Retinal Neurons/metabolism , Retinal Neurons/pathology , Retinitis/metabolism , Retinitis/pathology , Reverse Transcriptase Polymerase Chain Reaction , Tumor Necrosis Factor-alpha/genetics , Vascular Endothelial Growth Factor A/metabolism
8.
Beijing Da Xue Xue Bao Yi Xue Ban ; 40(4): 425-30, 2008 Aug 18.
Article in Chinese | MEDLINE | ID: mdl-18677393

ABSTRACT

OBJECTIVE: To investigate the expression of endoplasmic reticulum stress proteins in photoreceptor apoptosis in light-induced retinal degeneration. METHODS: Exposure to excessive levels of light induced photoreceptor apoptosis and had been previously used as a model for the study of retinal degeneration. Photoreceptor apoptosis was detected by terminal dUTP transferase nick end labeling (TUNEL). The protein expression levels of ER stress sensors including glucosejregulated protein-78 (GRP78/BiP), caspase-12, phospho-eukaryotic initiation factor 2alpha (eIF2alpha) and phospho- double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) were examined by immunojfluorescence and Western blot analysis. RESULTS: Following light exposure, the protein expression levels of GRP78/BiP, caspase-12, phospho-eIF2alpha and phospho-PERK were up-regulated in a time dependent manner. The up-regulation of these proteins coincided with or preceded the photoreceptor apoptosis. At the peak of their expression, they were mainly located in the photoreceptor inner segments and/or outer nuclear layers (ONL). CONCLUSION: Activation of endoplasmic reticulum stress proteins appears to play an important role in light-induced retinal degeneration. Therefore endoplasmic reticulum stress modulators could become a strong candidate for a therapeutic agent in treatment of these diseases.


Subject(s)
Endoplasmic Reticulum/metabolism , Heat-Shock Proteins/metabolism , Light/adverse effects , Photoreceptor Cells, Vertebrate/metabolism , Retinal Degeneration/metabolism , Animals , Apoptosis , Caspase 12/metabolism , Endoplasmic Reticulum/pathology , Endoplasmic Reticulum Chaperone BiP , Eukaryotic Initiation Factor-2/metabolism , Guinea Pigs , Male , Mice , Mice, Inbred BALB C , Photoreceptor Cells, Vertebrate/pathology , Rabbits , Random Allocation , Retina/metabolism , Retina/pathology , Retinal Degeneration/etiology , eIF-2 Kinase/metabolism
9.
J Neurosci Res ; 86(4): 910-9, 2008 Mar.
Article in English | MEDLINE | ID: mdl-17929311

ABSTRACT

Exposure to excessive levels of light induces photoreceptor apoptosis and has previously been used as a model for the study of retinal degeneration. During the light exposure, intracellular calcium levels increase, and reactive oxygen species (ROS) are generated, which have been shown to cause endoplasmic reticulum (ER) stress. In the present study, we investigated the role of ER stress in light-induced photoreceptor apoptosis. Our study demonstrated that, after light exposure, the ER stress sensors including glucose-regulated protein-78 (GRP78/BiP), caspase-12, phospho-eukaryotic initiation factor 2 alpha (eIF2 alpha), and phospho-pancreatic ER kinase (PERK) were significantly up-regulated in a time-dependent manner. The up-regulation of these proteins coincided with or preceded the photoreceptor apoptosis indicated by TUNEL. These data showed that ER stress played an important role in light-induced photoreceptor apoptosis. Therefore, ER stress modulators could be strong candidates as therapeutic agents in the treatment of retinal degenerative diseases.


Subject(s)
Apoptosis/physiology , Endoplasmic Reticulum/pathology , Light/adverse effects , Photoreceptor Cells, Vertebrate/pathology , Retinal Degeneration/pathology , Animals , Blotting, Western , Endoplasmic Reticulum/metabolism , Endoplasmic Reticulum Chaperone BiP , Fluorescent Antibody Technique , Gene Expression , In Situ Nick-End Labeling , Mice , Mice, Inbred BALB C , Photoreceptor Cells, Vertebrate/metabolism , Retina/pathology , Retinal Degeneration/metabolism
10.
Zhonghua Yan Ke Za Zhi ; 44(9): 807-12, 2008 Sep.
Article in Chinese | MEDLINE | ID: mdl-19175160

ABSTRACT

OBJECTIVE: To investigate the expression of endoplasmic reticulum (ER) stress proteins in photoreceptor apoptosis in rd mouse (Pde6bRd1/Rd1). METHODS: Photoreceptor apoptosis in rd mouse was detected by terminal dUTP transferase nick end labeling (TUNEL). The protein expression of ER stress sensors including glucose-regulated protein-78 (GRP78/BiP), caspase-12, phospho-eukaryotic initiation factor 2alpha (eIF2alpha) and phospho-pancreatic ER kinase (PERK) was examined by immunofluorescence and Western Blot analysis. RESULTS: Accompanying photoreceptor apoptosis in rd mouse, protein expression of GRP78/BiP, caspase-12, phospho-eIF2alpha and phospho-PERK was up-regulated in a time dependent manner. The up-regulation of these proteins coincided with or preceded the photoreceptor apoptosis. At the peak of their expression, they were mainly located in the photoreceptor inner segment and/or outer nuclear layer (ONL). CONCLUSION: Activation of ER stress proteins appears to play an important role in rd retinal degeneration. Therefore endoplasmic reticulum stress modulators could be a strong candidate as a therapeutic agent in the treatment of these diseases.


Subject(s)
Endoplasmic Reticulum/metabolism , Heat-Shock Proteins/metabolism , Retinal Degeneration/metabolism , Animals , Apoptosis , Endoplasmic Reticulum Chaperone BiP , Mice , Mice, Inbred Strains , Retinal Degeneration/genetics
11.
Invest Ophthalmol Vis Sci ; 48(11): 5191-8, 2007 Nov.
Article in English | MEDLINE | ID: mdl-17962473

ABSTRACT

PURPOSE: Endoplasmic reticulum (ER) stress has been implicated in a wide variety of neurodegenerative disorders of the central nervous system (CNS). This study was designed to elucidate the role of ER stress in photoreceptor apoptosis in the rd1 mouse. METHODS: Photoreceptor apoptosis in the rd1 mouse was detected by terminal dUTP transferase nick-end labeling (TUNEL). Protein expressions of ER stress sensors, including glucose-regulated protein-78 (GRP78/BiP), caspase-12, phospho-eukaryotic initiation factor 2alpha (eIF2alpha), and phospho-pancreatic ER kinase (PERK), were examined by immunofluorescence and Western blot assays. RESULTS: Accompanying photoreceptor apoptosis in the rd1 mouse, the protein expressions of GRP78/BiP, caspase-12, phospho-eIF2alpha, and phospho-PERK were upregulated in a time-dependent manner. The upregulation of these proteins coincided with or preceded photoreceptor apoptosis. At the peak of their expression, these proteins were primarily located in the photoreceptor inner segments, the outer nuclear layer, or both. CONCLUSIONS: ER stress plays an important role in photoreceptor apoptosis in the rd1 mouse. Therefore, ER stress modulators may be strong candidates as therapeutic agents in the treatment of retinal degenerative diseases.


Subject(s)
Apoptosis , Endoplasmic Reticulum/metabolism , Heat-Shock Proteins/metabolism , Photoreceptor Cells, Vertebrate/metabolism , Retinal Degeneration/metabolism , Animals , Blotting, Western , Caspase 12/metabolism , Endoplasmic Reticulum Chaperone BiP , Eukaryotic Initiation Factor-2/metabolism , In Situ Nick-End Labeling , Mice , Mice, Inbred C3H , Microscopy, Fluorescence , Molecular Chaperones/metabolism , Photoreceptor Cells, Vertebrate/pathology , Retinal Degeneration/pathology , Up-Regulation , eIF-2 Kinase/metabolism
12.
Zhonghua Yi Xue Za Zhi ; 86(48): 3420-4, 2006 Dec 26.
Article in Chinese | MEDLINE | ID: mdl-17313856

ABSTRACT

OBJECTIVE: To investigate the effects of chronic iodine excess on thyroid function, thyroid peroxidase (TPO) activity, and expression of sodium-iodide symporter (NIS). METHODS: 500 Wistar rats were randomly exposed to 4 doses of iodine 4 microg/d (G0, control), 6 microg/d (G1), 12 microg/d (G2), and 24 microg/d (G3) for 1, 2, 4 and 8 months. The urine iodine and tissue iodine was determined by arsenic/cerium catalyzing spectrophotograph. Radioimmunoassays were used to detect thyrotropin (TSH), free thyroxin (FT4), free triiodothyronine (FT3), total thyroxin (TT4), and total triiodothyronine (TT3). Guaiacol reaction method and potassium iodide oxygenation method were used to determine the activity of TPO. Suspension of single cells from thyroid tissue was made and the positive rate of NIS was determined by flow cytometry. The expression of NIS protein was assayed by immunohistochemistry. RESULTS: The urine iodine levels of G1, G2, and G3 were 1.5, 3, and 6 times of G0 respectively. FT4, FT3, and total iodine were found progressively accumulated in thyroid tissue with the elevation of iodine intake. The TPO activities of G2 and G3 at the 8th month were 0.17 +/- 0.04 and 0.15 +/- 0.03 respectively, both significantly lower than that of G0 (0.4 +/- 0.23, P < 0.05). The levels of iodine intake at different time points of G1-3 were significantly reduced in a iodine-dose dependent manner (r = -0.63 to -0.78, P < 0.01). The 131I intake at month 8 of G1, G2, and G3 were 56%, 49%, and 39% that of G0 respectively. At month 8 the NIS positive rates of G2 and G3 were significantly lower than that of G0 (both P < 0.05). The NIS protein positive rate was positively correlated with NIS protein expression intensity (r = 0.7-0.72, P < 0.01). The iodine content of thyroid tissue was negatively correlated with TPO activity, iodine intake rate, NIS protein positive rate and expression intensity (r = -0.62 to -0.88, P < 0.05). CONCLUSION: Moderate iodine excess continuously suppresses the thyroid iodine uptake and organification, which presents a mechanism for iodine-induced thyroid failure.


Subject(s)
Iodide Peroxidase/metabolism , Iodine/administration & dosage , Symporters/metabolism , Thyroid Gland/drug effects , Animals , Drug Overdose , Female , Iodine/pharmacokinetics , Iodine/toxicity , Ion Transport/drug effects , Male , Random Allocation , Rats , Rats, Wistar , Sodium/metabolism , Thyroid Gland/metabolism , Time Factors
13.
Shanghai Kou Qiang Yi Xue ; 12(1): 16-7, 2003 Feb.
Article in Chinese | MEDLINE | ID: mdl-14661454

ABSTRACT

OBJECTIVE: To compare the different management of relaxion incision in palatoplasty, and the treatment outcome. Methods 40 cases with cleft palate, who underwent palatoplasty, were classified into two groups: iodine gauze in incision and the control. The body temperature and the sign were recorded. RESULTS: The body temperature of the control was lower than that of the group whose incision were filled with iodine gauzes. Their complication and duration in hospital was less. CONCLUSION: The management of relaxion incision without packed iodine gauzes is feasible and safe.


Subject(s)
Cleft Palate/surgery , Palate/surgery , Body Temperature , Child , Child, Preschool , Female , Humans , Infant , Male , Oral Surgical Procedures
14.
Zhonghua Nei Ke Za Zhi ; 42(5): 316-9, 2003 May.
Article in Chinese | MEDLINE | ID: mdl-12882712

ABSTRACT

OBJECTIVE: To investigate the effects of several factors affecting serum thyroglobulin (TG) levels among people aged 14 or more. METHODS: We selected Panshan with median urinary iodine (MUI) 83.45 micro g/L as a deficient iodine intake community, Zhangwu with MUI 242.85 micro g/L as a sufficient iodine intake community and Huanghua with MUI 650.87 micro g/L as an excessive iodine intake community. Serum TG and thyroid stimulating hormone (TSH) were measured in 3,335 subjects whose thyroglobulin antibody (TGAb) were negative and thyroid volume were examined using B-ultrasound. RESULTS: In the population with MUI of 80 - 650 micro g/L, serum TG levels presented a "V" curve. An elevated serum TG was found in both the communities with deficient iodine intake and excessive iodine intake. The same trend was shown in the groups with different levels of serum TSH. An elevated serum TG was found in both the groups of TSH < 0.3 mU/L and TSH > 4.8 mU/L. The serum TG levels was positively correlated with thyroid volume and was higher in female subjects than in male. An increased serum TG was found in subjects of aged 50 in the community with deficient iodine intake. CONCLUSION: Serum TG level is affected by gender, amount of iodine intake, serum TSH level and thyroid volume.


Subject(s)
Iodine/administration & dosage , Thyroglobulin/blood , Adolescent , Adult , Aged , Female , Humans , Iodine/deficiency , Iodine/poisoning , Male , Middle Aged , Rural Population , Sex Factors , Thyroid Gland/diagnostic imaging , Thyrotropin/blood , Ultrasonography
15.
Zhonghua Yi Xue Za Zhi ; 83(23): 2036-9, 2003 Dec 10.
Article in Chinese | MEDLINE | ID: mdl-14703411

ABSTRACT

OBJECTIVE: To investigate the relationship between selenium status and thyroid dysfunction in 3 areas with different iodine intake. METHODS: An epidemiological research was performed in the rural communities of Panshan County (iodine-deficient area) and Zhangwu County (iodine-sufficient area), Liaoning Province, and Huanghua County, Hebei Province (iodine-excessive area). Serum selenium, TSH, FT3 and FT4 levels were examined in 329 patients with thyroid dysfunction (including clinical hypothyroidism, subclinical hypothyroidism, clinical hyperthyroidism and subclinical hyperthyroidism) and 183 normal inhabitants. RESULTS: The median serum selenium concentrations in Panshan, Zhangwu and Huanghua were 91.4, 89.1, and 83.2 microg/L respectively. There was no difference in serum selenium levels between the patients with subclinical hypothyroidism, clinical hypothyroidism, and clinical hyperthyroidism and their normal controls. The median serum selenium concentration of the subclinical hyperthyroidism patients was 82.6 microg/L, significantly lower than that of the normal controls (87.3 microg/L). The FT3/FT4 ratio was decreased, the FT4 level was increased in the subclinical hyperthyroidism patients in comparison with the normal controls, and no significant difference in FT3 level was found between them. No significant effect of sex and age was found on serum selenium level of normal inhabitants. In normal controls serum selenium was inversely correlated with serum TSH level, and the subjects with serum selenium < or = 80 microg/L had the median TSH level of 2.10 mU/L, markedly higher than that of the subjects with the serum selenium of 80-100 microg/L (1.29 mU/L) and that of the subjects with the serum selenium of 100 approximately 120 micro g/L (1.28 mU/L). For the thyroid dysfunction patients with positive thyroid auto-antibody (TPOAb) in Zhangwu County, the serum selenium was negatively associated with TPOAb level. The serum selenium level of the TPOAb highly positive group (TPOAb > 600 IU/ml) was 83.6 IU/ml, significantly lower than those of the TPOAb lowly positive group and TPOAb moderately positive group (83.6, 92.9 and 95.6 microg/L respectively). CONCLUSION: No obvious effect of selenium status is found on the development of thyroid dysfunction in these three areas. But selenium deficiency can impair thyroid function by means of disturbing thyroid hormone metabolism and decreasing antioxidant ability of the thyroid.


Subject(s)
Iodine/administration & dosage , Selenium/blood , Thyroid Gland/physiology , Age Factors , Autoantibodies/blood , Female , Humans , Male , Sex Factors , Thyroid Gland/immunology , Thyroid Hormones/blood
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