ABSTRACT
Two new trinuclear zinc(II) complexes, [Zn3I2L2(H2O)2] (1) and [Zn3(CH3OH)(DMF)L2(NCS)2] (2), where L is the dianionic form of N,N'-bis(5-bromosalicylidene)-1,2-cyclohexanediamine (H2L), have been synthesized and characterized by elemental analyses, IR and UV spectra. Structures of the complexes were further confirmed by single crystal X-ray diffraction. Both complexes are trinuclear zinc compounds. Both compounds are solvated, with water ligand for 1 and methanol ligand for 2. The outer two Zn atoms are in square pyramidal coordination, while the inner one is in octahedral coordination. The effect of the complexes on the antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans were evaluated, and gave interesting results.
ABSTRACT
A series of hydrazones, (E)-N'-(4-hydroxy-3-methoxybenzylidene)-4-nitrobenzohydrazide (1), (E)-4-(dimethylamino)-N'-(4-hydroxy-3-methoxybenzylidene)benzohydrazide (2), N'-(2-hydroxy-5-methylbenzylidene)-4-nitrobenzohydrazide (3) and 2-fluoro-N'-(2-hydroxy-5-methylbenzylidene)benzohydrazide (4), were prepared and structurally characterized by elemental analysis, IR and 1H NMR spectra, and X-ray single crystal determination. The xanthine oxidase inhibitory activities of the compounds were investigated. Among the compounds, N'-(3-methoxybenzylidene)-4-nitrobenzohydrazide (1) showed the strongest activity. Docking simulations were performed to insert the compounds into the crystal structure of xanthine oxidase at the active site and to investigate the probable binding modes.
