Global research on Obsessive Compulsive Disorder and related disorders: A scientometric assessment of global research during 2002-2021.

OBJECTIVES: to examine the global publication output on Obsessive Compulsive Disorder (OCD) during the last 20 years using bibliometric methods. METHODS: The quantitative and qualitative analysis of global publications was performed for all the publications in Scopus database by using "OCD, Obsessive Compulsive Disorder, other related disorders" as keyword in "Title" tag. RESULTS: 10,365 publications on OCD and related disorders were indexed in Scopus international database in the last 20 years and these publications were cited 241,962 times, averaging 23.34 citations per paper (CPP). About 24.91% share of global publication output received funding support and registered a CPP of 36.57. Among various countries, authors from USA, U.K., and Germany contributed the largest number of publications (3585, 965, and 836 publications), and publications arising from Netherlands (36.79 and 1.58), U.K. (32.65 and 1.40), and USA (32.43 and 1.39) registered the highest CPP and relative citation index (RCI). The organizations that produced the highest number of publications were Harvard Medical School, USA (487 papers), Massachusetts General Hospital, USA (454 papers), and King's College London, U.K. (297 papers). The authors who published highest number of papers were E.A. Storch (254 papers), D. Mataix-Cols (178 papers), and D.J. Stein (178 papers). The authors whose publications had highest CPP and RCI were B.D. Greenberg (USA) (73.76 and 3.16), and S.A. Rasmussen (USA) (63.36 and 2.71). CONCLUSIONS: This study reveals that majority of the research on OCD and related disorders is from the developed countries and compared to disorders like schizophrenia, OCD has received less research attention.

A scientometric study of publications on delirium from 2001 to 2020.

AIM: This study aims to evaluate the publications on delirium by using bibliometric analysis. METHODOLOGY: The Scopus database was evaluated for publications on delirium, during the period of 2001-20. The search results were analyzed for the origin of country, origin of institution, authorship, collaborations, type of article, source of funding, and number of citations. RESULTS: The searches of Scopus database yielded 22,941 publications, originating from 139 countries. Compared to the decade of 2001-2010, the number of publications on delirium doubled in the decade of 2011-2020. The majority of the papers were research articles (58.26%), and the papers were cited for mean number of 20.53 times. Only a small proportion of the papers were based on funding (13.14%). Maximum number of papers emerged from United States of America. In terms of institutional affiliations, among the authors from top 20 institutes, 15 were from United States, 2 from Netherlands and 1 each from Canada, Germany and United Kingdom. In terms of authors, the research productivity of the top 20 most productive authors varied from 172 to 612 publications with 12 authors belonging to United States, 2 from Italy and 1 each from Canada, Greece, India, Ireland, Netherland and the United Kingdom. The maximum number of papers were published in Journal of the American Geriatric Society and based on the number of citations the New England Journal of Medicine was the most impactful journal. CONCLUSION: Over the years number of publications on delirium have increased, majority of the publications have emerged from United States.

COVID-19 and suicidal behavior: A bibliometric assessment.

The paper examines the global research output on suicidal behavior during the COVID-19 pandemic. The Scopus database was used to identify the publications on suicidal behavior during the COVID-19 pandemic from the beginning of the pandemic to up to 17th May 2021. The 686 publications emerging from 78 countries were found on the topic. These publications received 7970 citations, with an average of 11.62 citations per paper. About one-sixth (16.33%) of the total publications were funded, and these publications averaged 17.24 citations per paper. The publications from the top 10 most productive countries accounted for 92.71% of all publications. The highest number of publications emerged from United States, United Kingdom, and India. However, the relative citation index was highest for publications arising from France, Bangladesh, and Germany. The total number of organizations and authors involved in these publications were 286 and 290, respectively. The top 20 most productive organizations and authors contributed to 35.13% and 17.64% of publications and 79.15% and 58.61% global citations share, respectively. The maximum number of papers were published in the Asian Journal of Psychiatry, followed by Psychiatry Research and Lancet Psychiatry. This study suggests that suicidal behavior has received considerable attention during the ongoing COIVD-19 pandemic.

Schizophrenia research in India: A scientometric assessmentof India's publications during 1990-2019.

The present study examined India's publications (2803) on schizophrenia, using various bibliometric indicators during 1990-2019. The study focuses on the number of publications, and citations received by the papers on schizophrenia, published by authors affiliated to Indian institutes by using Scopus data base. Additionally, an attempt was made to evaluate the performance of India's leading organizations and authors, and inter-collaborative linkages between them. Scopus database include publications of Indian Journal of Psychiatry and Indian Journal of Psychological Medicine from 2009 and 2011. Accordingly, the publications in these journals were included after these years. Analysis of the publications showed that India is globally ranked at 13th position in number of publications on schizophrenia with 2.04 % global share, depicting 14.21 % annual growth, with 22.8 % of publications having international collaboration. Publications from India published during the period of 1990-2019, registered a citation impact per paper (CPP) of 13.3. National Institute of Mental Health and Neurosciences, Bangalore (671 papers), Post Graduate Institute of Medical Education and Research, Chandigarh (271 papers) and Central Instittue of Psychiatry, Ranchi (136 papers) were the most productive institutes. However, the most impactful organizations in terms of citation per paper (CPP) and relative citation index (RCI), Indian Institute of Science, Bangalore (77.27 CPP and 5.78 RCI), Schizophrenia Research Foundation, Chennai (31.16 CPP and 2.55 RCI) and Banaras Hindu University, Varanasi (29.21 CPP and 2.18 RCI) were at the top. In terms of Individual authors, G. Venkatasubramanian (180 papers), and B.N. Gangadhar (162 papers) were the most productive authors and R.Thara (31.87 CPP and 2.38 RCI), B.K. Thelma (24.0 CPP and 1.8 RCI), M.S. Keshavan (23.91 CPP and 1.79 RCI) were the most impactful authors, among the top 15 authors. The journals which reported comparatively higher productivity for Indian publications included Indian Journal of Psychiatry (242 papers), followed by Asian Journal of Psychiatry (214 papers) and Indian Journal of Psychological Medicine (103 papers). In terms of most impactful Indian publications, these were published in The Lancet (97.7), Progress in Neuro Psychopharmacology & Biological Psychiatry (50) and Schizophrenia Bulletin (44.67).

Research on bipolar disorder from India: A bibliometric analysis of papers published during 2000-19.

The paper examines 1037 publications on bipolar disorder (BD) during the years 2000-19 from India, as listed in the Scopus database. India's publications constituted 2.27 % share of global output (45,624 publications) in the study period of 20 years. India does not figure in the top 10 countries in terms of research output on BD. The number of publications on BD from India increased from 13 in 2000 to 107 in 2019, registering 14.44 % annual average growth, higher than world's growth of 6.02 %. India's 10-year cumulative publications increased from 264 during 2000-09 to 773 during 2010-19, registering 192.8 % absolute growth, much higher than world cumulative growth of 63.27 %. India's publications on BD averaged citation impact per paper of 14.24, which decreased from 25.38 to 10.43 from 2000-09 to 2010-19. Maximum numbers of papers from India on BD were published by researchers from National Institute of Mental Health and Neurosciences, Bangalore (222 papers),Post Graduate Institute of Medical Education and Research, Chandigarh(118 papers), and AII India Institute of Medical Sciences, New Delhi (79 papers). Lady Harding Medical College, New Delhi (36.20 and 2.54), Schizophrenia Research Foundation, Chennai (27.45 and 1.93), and King George's Medical University, Lucknow (25.21 and 1.77) were the most significant organizations in terms of citation per paper and relative citation index. Maximum number of papers were published in Indian Journal of Psychiatry (101 papers), followed by Asian Journal of Psychiatry (88 papers) and Indian Journal of Psychology Medicine (34 papers).

Pharmaceutical research in the Kingdom of Saudi Arabia: A scientometric analysis during 2001-2010.

Studies on the performance of Saudi Arabia in the pharmaceutical science research using quantitative and qualitative measures. They analyze the productivity and global publication share and rank of the top 15 countries. The author studies Saudi Arabia's publications output, growth and citation quality, international collaborative publication share and most important the collaborating partners, contribution and citation impact of its top 15 organizations and authors, productivity patterns of its top publishing journals and characteristics of its highly cited papers.

A scientometrics approach to schizophrenia research in India: an analysis of publications output during 2002-11.

OBJECTIVES: This study analyses the research output of India in schizophrenia research during 2002-11 on several parameters including the growth, rank and global publications share, citation impact, share of international collaborative papers, contribution of major collaborative partner countries, contribution of various subject-fields, contribution and impact of most productive institutions and authors, media of communication and characteristics of high cited papers. METHODS: The Scopus Citation Database has been used to retrieve the data for 10 years (2002-11) by searching the keywords schizophrenia research in the combined Title, Abstract and Keywords fields. RESULTS: Among the top 20 most productive countries in schizophrenia research, India ranks at 15th position (with 882 papers) with a global publication share of 1.58% and an annual average publication growth rate of 21.80% during 2002-11. Its citation impact per paper was 3.60 international collaborative publications share was 26.98% during 2002-11. CONCLUSIONS: Concludes that India needs to increase both the quantity and quality of research and also increase the international collaborative research, besides strengthening and modernizing its research infrastructure. There is need to treat schizophrenia as a priority area in the current and future national S & T plans of India.

Mapping of asthma research in India: A scientometric analysis of publications output during 1999-2008.

OBJECTIVE: This study analyzes the research output of India in asthma during the period from 1999 till 2008. It analyzes the growth, rank and global publications share, citation impact, share of international collaborative papers, contribution of major collaborative partner countries and contribution of various subject fields. It also analyzes the characteristics of most productive institutions, authors and high-cited papers. MATERIALS AND METHODS: SCOPUS database has been used to retrieve the data on publication output in asthma research. RESULTS: India ranks 15(th) position among the top 23 countries in asthma research, with its global publication share of 1.27% (862 papers), registering an average citation per paper of 3.43 and achieved an h-index of 33 during 1999-2008. CONCLUSION: Indian research output on asthma is quite low in the global context as reflected from its publication output per thousand population (0.001) and its world publication share (1.27%) during 1999-2008. Also, the impact and quality of Indian research is low compared to select developed and developing countries.

A bibliometric analysis of malaria research in India during 1998-2009.

OBJECTIVE: This study analyses the research output of India in malaria research in national and global context, as reflected in its publications output during 1998-2009. METHODS: SCOPUS Citation database has been used to retrieve the publication data, which has been further analysed on several parameters including its growth, rank and global publications share, citation impact, overall share of international collaborative papers and share of major collaborative partners and patterns of research communication in most productive journals. The publications output, impact and collaborative publication share of India is also compared with South Africa, Brazil and China. RESULTS: Indian scientists together have published 2786 papers in malaria research during 1998-2009 and registered an average citation per paper of 3.49. The country ranks 4th among the top 20 most productive countries in malaria research with its global publications share of 6.47% during 1998-2009. CONCLUSION: Quantum of Indian research output in malaria research is high but its citations per paper is low compared to select developing countries, which can be improved by investing more funds in international and national collaborative research projects, as well as increasing the participation of researchers in such projects.

A scientometric analysis of Indian research output in medicine during 1999-2008.

OBJECTIVE: This study analyzes the research activities of India in medicine during 1999-2008, based on the total publication output, its growth rate, quality of papers published and rank of India in the global context. Patterns of international collaborative research output and the major partner countries of India are also discussed. This study also evaluates the research performance of different types of Indian medical colleges, hospitals, research institutes, universities and research foundations and the characteristics of published literature in Indian and foreign journals. It also analyzes the medical research output by disease and organs. MATERIALS AND METHODS: The publication data on medicine has been retrieved by using SCOPUS database. RESULTS: India holds 12th rank among the productive countries in medicine research consisting of 65,745 papers with a global publication share of 1.59% and registering a growth rate of 76.68% for the papers published during 1999-2003 to 2004-2008. CONCLUSION: High quality research in India is grossly inadequate and requires strategic planning, investment and resource support. There is also a need to improve the existing medical education system, which should foster research culture.

Mapping of Indian neuroscience research: a scientometric analysis of research output during 1999-2008.

OBJECTIVE: This study analyses the research output in India in neurosciences during the period 1999-2008 and the analyses included research growth, rank, global publications' share, citation impact, share of international collaborative papers and major collaborative partner countries and patterns of research communication in most productive journals. It also analyses the characteristics of most productive institutions, authors and high-cited papers. The publication output and impact of India is also compared with China, Brazil and South Korea. MATERIALS AND METHODS: Scopus Citation database was used for retrieving the publications' output of India and other countries in neurosciences during 1999-2008. RESULTS: India's global publications' share in neurosciences during the study period was 0.99% (with 4503 papers) and it ranked 21 st among the top 26 countries in neurosciences. The average annual publication growth rate was 11.37%, shared 17.34% of international collaborative papers and the average citation per paper was 4.21. India was far behind China, Brazil and South Korea in terms of publication output, citation quality and share of international collaborative papers in neurosciences. CONCLUSION: India is far behind in terms of publication output, citation quality and share of international collaborative papers in neurosciences when compared to other countries with an emerging economy. There is an urgent need to substantially increase the research activities in the field of neurosciences in India.

Mapping of neuroscience research: a quantitative analysis of publications output of China, 1999-2008.

BACKGROUND: Neuroscience is one of the most active research fields in many countries including China since 1970. The Chinese neuroscientists are playing an ever growing and important role in IBRO activities for the development of worldwide cooperation in Brain research. PURPOSE: The main objective of this study is to analyze the research performance of China in neurosciences in national and global context, as reflected in its publication output during 1999-2008. METHODS: This study is based on the Chinese publication data in neurosciences retrieved from the Scopus Citation database for the 10 years (1999-2008). Several parameters including total research output, its growth, rank and global publication share, citation impact, share of international collaborative papers and major collaborative partner countries and patterns of research communication in most productive journals were studied. RESULTS: China's world ranking improved to 8(th) position in 2008. The cumulative publication output of China accounts for 39.69 % share of international collaborative papers during 1999-2008. Chinese authors in neuroscience field together contributed 794 papers, with an average of 49.63 papers per author. CONCLUSION: The top 49 highly cited papers in neurosciences from China had scored higher impact with 126.73 citations per paper. These 49 high-cited papers have appeared in 25 journals and are affiliated to 32 Chinese institutions.

Protective effect of fungal growth product (6MFA), assessed therapeutically against Ehrlich's ascites tumor in Swiss mice.

6MFA is a growth product of the fungus Aspergillus ochraceus (ATCC 28706) obtained by fermentation in stationary culture. It has both interferon inducing and antiviral properties, in vivo and in vitro, with a relatively high margin of safety (9, 17, 18). Ehrlich's ascites tumor bearing Swiss albino male mice were treated with 0.5 ml of acqueous preparation of 6MFA (0.75 mg total solids) i.p. in a therapeutic regimen schedule; the sham treated mice received only PBS. 6MFA treatment produced an increase in mean survival time over the untreated controls, restricted the body weight increase due to ascites and decreased the rate of mortality. As much as 100% of survival response was obtained in the group treated with 0.5 ml of 6MFA at the rate of one inoculation per week for 5 weeks. In general a dose-dependent response was seen in the antitumor effect of 6MFA against Ehrlich's ascites tumor in Swiss mice. Delay in administration of 6MFA to tumor bearing mice affected the survival rate.

Sixth mycelial fraction acetone (6-MFA), an interferon inducer modulates acrylamide neurotoxicity.

A single i.p. administration of an immunomodulatory agent 6-MFA (a biological response modifier and antiviral agent of fungal origin, 10 mg/100g b.wt.), on 5th day of repeated acrylamide (ACR, 50 mg/kg b.wt.) treatment significantly protected rats against its specific neurotoxic effects. Corpus striatal 3H-spiperone binding elevated (24%) while glutathione-S-transferase (GST) activity decreased (33%) in ACR group but values were markedly restored in 6-MFA alone and co-exposed group. Development of hind limb paralysis was also protected by 6-MFA. Results warrant the possible involvement of immune mechanisms and certain other factors such as lymphokines, hormones and microglia at the target site, which in turn facilitate the repair mechanism suggesting a therapeutic role of 6-MFA in clinical cases of toxic neuropathies in future.

Protective effect of 6-MFA, an interferon inducer against acrylamide neurotoxicity.

Protective effect of 6-MFA, an interferon inducer and antiviral agent of fungal origin, was investigated against the neurotoxic effects induced by acrylamide in rats. Animals of 6-MFA (2.5, 5, 10 mg/100 gm, i.p.) pretreated plus acrylamide (ACR) group exhibited a reduction in development of hind limb paralysis which was 34, 25 and 20 (%) with increasing doses of 6-MFA respectively. Corpus striatal dopamine binding was significantly raised in the ACR treated rats while 6-MFA (10 mg) plus ACR group showed no significant change, in comparison to respective controls. Increased binding in the 6-MFA (2.5, 5 mg) pretreated plus ACR group was also evident. Glutathione-s-transferase (GST) activity was markedly reduced (66%) in ACR alone rats while no change was noted in rats pretreated with either dose of 6-MFA alone. However, a significant reversal was noted in animals of 6-MFA plus ACR group in a dose related manner. Conservation of glutathione levels and involvement of microglia, gamma-interferon and other lymphokines has been suggested for the observed protective effect of 6-MFA against neurotoxicity of ACR.

Antiviral activity in plants of a mycoviral double-strained RNA from Trichothecium roseum.

Hexagonal virus-like particles (VLPs) measuring 45 nm across were detected in mycelial extracts from Trichothecium roseum Himachal strain, the source fungus for the production of T-poly (Trichothecium polysaccharide), a known inhibitor of plant viruses. VLPs were found to contain double-stranded RNA (ds RNA) and the purified ds RNA was capable of inhibiting tobacco mosaic virus infection in Nicotiana glutinosa plants. Active preparations of T-poly were found to contain traces of ds RNA, probably of mycoviral origin.