Subject(s)
Atlanto-Axial Joint/injuries , Joint Dislocations/congenital , Adolescent , Adult , Atlanto-Axial Joint/diagnostic imaging , Child , Child, Preschool , Female , Humans , Joint Dislocations/complications , Joint Dislocations/diagnostic imaging , Male , Middle Aged , Radiography , Spinal Cord Compression/diagnostic imaging , Spinal Cord Compression/etiologySubject(s)
Epilepsy/drug therapy , Phenobarbital/administration & dosage , Adolescent , Adult , Child , Female , Humans , Kinetics , Male , Metabolic Clearance Rate , Phenobarbital/metabolismABSTRACT
Osmotic shock was applied to phage T2 in such a manner that the compact-mass of DNA was released from phage. The shape of this compact-mass of DNA was studied under electron microscope. It appeared that the DNA was packed into an elongated icosahedron similar to the phage head.
Subject(s)
DNA, Viral/analysis , T-Phages/ultrastructure , Escherichia coli/ultrastructure , Microscopy, Electron , Osmolar ConcentrationSubject(s)
Hemostasis , Nephrotic Syndrome/blood , Adolescent , Adult , Child , Factor V/metabolism , Female , Fibrinogen/metabolism , Humans , Male , Middle AgedSubject(s)
DNA , Histones , Animals , Cattle , Chickens , Erythrocytes , Histones/blood , Microscopy, Electron , Protein Binding , Thymus GlandSubject(s)
Antihypertensive Agents/therapeutic use , Hypertension/drug therapy , Methoxamine/therapeutic use , Adult , Aged , Female , Humans , Male , Middle AgedSubject(s)
Asthma/immunology , Immunity, Cellular , Adolescent , Adult , Eosinophils , Female , Humans , Leukocyte Count , Lymphocytes , Male , Middle Aged , T-Lymphocytes/immunologyABSTRACT
3-Methoxy-4-hydroxyphenylglycol (MHPG) was measured in lumbar spinal fluid of 20 subjects with hypertension of varied etiology and severity. There was a significant correlation between the concentration of MHPG and the severity of hypertension. However, changes in the concentration of vanillylmandelic acid in the urine of these subjects were insignificant. In six subjects, administration of clonidine or alpha-methyldopa, two centrally acting antihypertensive drugs, was associated with a significant lowering of MHPG concentrations. These data support the hypothesis that central catecholamines are involved in clinical hypertension.
Subject(s)
Glycols/cerebrospinal fluid , Hypertension/metabolism , Methoxyhydroxyphenylglycol/cerebrospinal fluid , Vanilmandelic Acid/urine , Blood Pressure/drug effects , Clonidine/pharmacology , Female , Humans , Male , Methyldopa/pharmacologyABSTRACT
85 patients with a variety of ischemic heart diseases were examined for the proportion of T cells and the presence of anticardiac antibodies. Patients with acute myocardial infarction during the 2nd and 3rd week of initial acute episode had a higher proportion of T lymphocytes and a higher proportion of patients developed anticardiac antibody. Similar was the case with patients with angina. The extent of infarction and accompanying complications did not change the immune parameters studied. The relationship of anticardiac antibodies and T lymphocytes in context of ischemic heart diseases is discussed.
Subject(s)
Antibodies/analysis , Coronary Disease/immunology , Myocardium/immunology , T-Lymphocytes/analysis , Acute Disease , Humans , Myocardial Infarction/immunology , Time FactorsSubject(s)
Hypnotics and Sedatives , Quinazolines/pharmacology , Tranquilizing Agents , Adolescent , Adult , Clinical Trials as Topic , Double-Blind Method , Humans , Male , Middle AgedABSTRACT
PIP: A pharmacological evaluation of centchroman (3,4-trans-2,2,dimethyl-3-phenyl-4-p-(beta-pyrrolidino ethoxy)-phenyl-7-methoxychroman), a new postcoital contraceptive, in normal healthy human volunteers was performed to determine the maximum tolerated dose and to discover any abnormal toxic effects in humans. The study was carried out for both men and women as a double-blind noncrossover trial in 2 parts: 1) a single dose study (40 volunteers) and 2) a multiple dose study (28 females) for 30 days. Centchroman was well tolerated without significant side effects in single doses up to 320 mg, severalfold higher than the anticipated therapeutic dose. In the multiple dose schedule, the compound was found safe at doses of 60-120 mg/day. however, similar effects were observed in subjects receiving placebo and are not unexpected in a normal population over a 1-month period. Centchroman is presently undergoing clinical trials for postcoital contraceptive efficacy in humans.^ieng
Subject(s)
Benzopyrans/toxicity , Centchroman/toxicity , Adult , Clinical Trials as Topic , Double-Blind Method , Drug Administration Schedule , Female , Humans , Male , PlacebosABSTRACT
A double-blind placebo controlled study of angina pectoris with penbutolol was undertaken in parallel groups in fifty-two patients. The duration of the study was six weeks. The dosage range for penbutolol was 8 mg to 50 mg per day. Six patients were dropped from the analysis. Seventeen patients (81%) in the penbutolol series exhibited a 50% reduction in anginal attacks, NTG consumption and subjective improvement. Significant reduction in nitrite intake was observed. Effort tolerance was improved significantly in those receiving penbutolol. Penbutolol was well-tolerated.