ABSTRACT
BACKGROUND: Vitiligo affects 1% of the world's population with a higher incidence in dark-skinned individuals. Many medical treatments have been attempted with partial success, but recent focus has been on surgical techniques. The aim of this study was to evaluate and compare the therapeutic efficacy of dermabrasion, dermabrasion combined with 5% 5-fluorouracil cream, and dermabrasion combined with topical placentrex gel in the management of localized stable vitiligo. METHODS: Thirty patients with localized stable vitiligo (at least three lesions each) were treated. After dermabrasion, a soframycin tulle dressing was placed on the first lesion, a topical 5% 5-fluorouracil dressing on the second, and a topical placentrex gel dressing on the third for 7 days after the procedure, and the patients were followed up for 6 months. RESULTS: The efficacy of treatment was highest (73.33%) and most rapid in lesions treated with dermabrasion combined with 5-fluorouracil. Dermabrasion alone and dermabrasion combined with placentrex gel showed similar efficacy in localized stable vitiligo. CONCLUSION: Dermabrasion combined with 5-fluorouracil is the most efficacious of the three treatment modalities studied.
Subject(s)
Dermabrasion , Dermatologic Agents/therapeutic use , Fluorouracil/therapeutic use , Placental Extracts/therapeutic use , Vitiligo/drug therapy , Vitiligo/surgery , Administration, Topical , Adult , Cicatrix, Hypertrophic/etiology , Combined Modality Therapy , Dermatologic Agents/adverse effects , Female , Fluorouracil/adverse effects , Follow-Up Studies , Humans , Male , Occlusive Dressings , Skin/pathology , Treatment Outcome , Vitiligo/pathology , Wound Healing/drug effectsABSTRACT
Condyloma acumianata is one of the most common virally transmitted diseases. Its prevalence has increased many fold throughout the world. Because all the currently available treatments yield low cure rates with side effects, the search for a new alternative continues. Topically, 5-fluorouracil (5-FU) has been in used for many years to treat various skin diseases. When applied topically in condyloma acuminata, 5-FU results in low cure rates with high recurrences. Therefore, intralesional 5% 5-FU is being evaluated to determine its therapeutic efficacy in condyloma acuminata.
Subject(s)
Antimetabolites, Antineoplastic/administration & dosage , Condylomata Acuminata/drug therapy , Fluorouracil/administration & dosage , Neoplasm Recurrence, Local/drug therapy , Adolescent , Adult , Aged , Condylomata Acuminata/pathology , Female , Genital Diseases, Female/drug therapy , Genital Diseases, Female/pathology , Genital Diseases, Male/drug therapy , Genital Diseases, Male/pathology , Humans , Injections, Intralesional , Male , Middle Aged , Neoplasm Recurrence, Local/pathology , Treatment OutcomeABSTRACT
Scabies is an infestation caused by Sarcoptes scabiei and characterised by polymorphous lesions that may include burrows, papules, nodules, excoriation and crusts. Vesicular and bullous lesions are rather rare. Several diseases may be confused with scabies. We report a case of bullous scabies which, on the basis of the clinical and histopathological picture, mimicked bullous pemphigoid. Direct and indirect immunofluorescence were negative. Bullae recurred and persisted despite systemic corticosteroids. The patient was successfully treated with 5% permethrin and remained disease free for up to 12 months of follow-up.
Subject(s)
Scabies/diagnosis , Animals , Diagnosis, Differential , Female , Humans , Insecticides/therapeutic use , Middle Aged , Pemphigoid, Bullous/diagnosis , Permethrin/therapeutic use , Sarcoptes scabiei , Scabies/drug therapy , Scabies/pathology , ThighSubject(s)
Herpes Zoster/congenital , Herpes Zoster/diagnosis , Infectious Disease Transmission, Vertical , Pregnancy Complications, Infectious/virology , Female , Follow-Up Studies , Humans , Infant, Newborn , Pregnancy , Pregnancy Complications, Infectious/diagnosis , Remission, Spontaneous , Risk AssessmentABSTRACT
Thirty patients with localised stable vitiligo were selected from the Out Patient Department for cosmetic tattooing. Of them, 19 cases (63.3%) had skin patches, 9 cases (30%) had mucosal patches, and 2 cases (6.7%) had both skin and mucosal involvement. After complete clinical evaluation, cosmetic tattooing was performed on these patients, and they were followed up for 6 months. As results, 23 cases (76.7%) had excellent color matching, 2 cases (6.7%) had good color matching, and 5 cases (16.6%) had pigment shedding. Excellent results were seen in all mucosal patches. Dark complexion cases showed better results than fair complexion ones.
