ABSTRACT
Congenital heart disease (CHD) affects 8 to 10 children out of every 1,000 live births. Of these, 2.2% have an abnormality associated with the spleen. Many previous studies have associated CHD and asplenia or polysplenia syndrome. We report a case of a 12-year-old girl with complex CHD who was noted to have Howell-Jolly bodies on her peripheral blood smear at birth, but disappeared at 2 months of age and radiographic evidence of splenic tissue with situs inversus. Unfortunately, she presented with overwhelming sepsis at 20 months of age. In this paper, we discuss multiple tests available for evaluating splenic function in children with CHD and heterotaxia. Hepatoiminodiacetic acid (HIDA) scan in conjunction with radiocolloid scan is the best available choice today to document the presence or absence of a functional spleen in children with heterotaxia and CHD.
Subject(s)
Double Outlet Right Ventricle/genetics , Situs Inversus/genetics , Spleen/abnormalities , Child , Chromosome Aberrations , Clinical Laboratory Techniques , Diagnosis, Differential , Double Outlet Right Ventricle/complications , Erythrocyte Inclusions , Female , Gold Colloid, Radioactive , Humans , Magnetic Resonance Imaging , Radiography, Abdominal , Situs Inversus/complications , Spleen/diagnostic imaging , Spleen/pathology , UltrasonographyABSTRACT
Testicular functions in the form of testosterone, FSH and LH levels in serum by radio-immuno-assays, complete semen examination and a few testicular biopsies were studied in 30 men with leprosy (LL-7, BL-6, BB-1, BT-12 and 'fT-4). Serum testosterone levels were lowered in all the groups. Serum FSH and LH levels were elevated in lepromatous and borderline .1epromatous leprosy. Semen analysis showed oligospermia in LL and BL groups. Lepra bacilli in smars of semen were present in 2 LL case. Leprous changes were seen in the testicular biopsies.
ABSTRACT
A case of pemphigus foliaceus clinically resembling dermatitis - herpetiformis is being reported. Patient did not respond to dapsone. Later on the basis of histology a diagnosis of pemphigus foliaceus was established. Cases having over lapping features of pemphigus foliaceus and dermatitis herpetiformis have been reported earlier by other workers.
