[Ways and means for prolonging the action of drugs (the status of the problem and the outlook)]. / Puti i sposoby prolongirovaniia deistviia lekarstvennykh sredstv (sostoianie voprosa i perspektivy).

The modern approaches and concrete variants of the up-to-date means of prolongation of the biological effects of medicinal compounds having high tropic target-structures in the organism (pharmacodynamic drugs) are summarized. According to the principles of the influence on biodistribution, pharmacodynamics and metabolism of drugs, three main methods of prolongation: (technological (pharmaceutical), chemical and physiological are distinguished. The expediency of distinguishing a new method of prolongation--immunological is grounded. During the use of the method a drug in the complex with specific immunoglobulins of certain serological characteristics is a reversible depot-form of the preparation under in vivo conditions that provides the effect of prolongation.