ABSTRACT
A method for measurements of blood antigen-binding lymphocytes sensitized to Helicobacter antigens is suggested. Use of this method together with urease test will improve Helicobacter infection detection rate by 22%.
Subject(s)
Duodenal Ulcer/microbiology , Helicobacter Infections/diagnosis , Helicobacter pylori/isolation & purification , Helicobacter pylori/enzymology , Helicobacter pylori/immunology , Humans , Stomach/microbiologyABSTRACT
The influence of myelopid on immunological characteristics in experimental Salmonella infection has been studied. This preparation has been found to produce a pronounced effect on the characteristics of immune response: it increases the number of T- and B-lymphocytes in the blood and the lymphoid organs. The indirect rosette-formation test has shown that myelopid facilitates earlier and more rapid binding and elimination of the antigen (S. typhimurium) from the body. Under the influence of myelopid the release of antigen-binding lymphocytes from the thymus to the peripheral lymphoid organs becomes more intensive.
Subject(s)
Activins , Adjuvants, Immunologic/therapeutic use , Oligopeptides , Peptides/therapeutic use , Salmonella Infections, Animal/drug therapy , Animals , Antigens, Bacterial/metabolism , B-Lymphocytes/drug effects , B-Lymphocytes/immunology , Drug Evaluation, Preclinical , Mice , Mice, Inbred C57BL , Salmonella Infections, Animal/immunology , Salmonella typhimurium/immunology , T-Lymphocytes/drug effects , T-Lymphocytes/immunology , Time FactorsABSTRACT
The data on the count of antigen-binding lymphocytes in the blood and lymphoid organs of mice in the course of Salmonella infection are presented. The reaction used for their detection is specific. Antigen-binding lymphocytes detected in mice in Salmonella infection belong to T- and B-cell populations and carry surface receptors belonging to IgA and IgM. Study of antigen-binding lymphocytes 1-20 hours after infection may be helpful in the specific diagnosis of Salmonella infections.
