[The effect of verapamil on cardio- and hemodynamics in rats with various models of hypertension]. / Vliianie verapamila na kardio- i gemodinamiku krys s razlichnymi modeliami gipertenzii.

Rats with various models of hypertension (spontaneous, renal, neurogenic, adreno-regenerative) were used in experiments to study the effect of verapamil on parameters of cardio- and hemodynamics in its two-week oral administration. The antihypertensive effect of verapamil was most expressed in rats with spontaneous model of hypertension and initial hyperkinetic variant of circulation.

[The anti-ischemic properties of crown ether derivatives]. / Protivoishemicheskie svoistva proizvodnykh kraun-éfirov.

Experiments on open-chest anaesthetized cats were made to test derivatives of crown ethers, such as benzylase-15-crown-5 and dibenzylase-15-crown-5 for their effects on myocardial ischemia and the functional status of a myocardial ischemic focus in temporary coronary occlusion during coronary spasm induced by dihydroergotamine and during coronary microthrombosis caused by ADP. When intravenously administered in doses of 0.5-15 mg/kg, the tested agents were found to enhance myocardial tolerance to ischemia, depressed ST segment in ischemia induced by coronary occlusion and administration of ATP, and prevented ST-segment depression during coronary spasm.

[The relationship between the magnitude of the negative inotropic action and chemical structure of crown-ether derivatives]. / Zavisimost' mezhdu velichinoi otritsatel'nogo inotropnogo deistviia i khimicheskoi strukturoi proizvodnykh kraun-éfirov.

The relationship between the inotropic effect and chemical structure of 15-crown-5 and 18-crown-6 derivatives was studied in experiments in open-chest anaesthesized cats, by using computer-aided analysis. The findings showed that the 15-crown-5 derivatives produced more pronounced cardiotropic effect and they were less toxic than 18-crown-6 derivatives. Computer-aided analysis revealed pharmacophoric groups which are responsible for cardiotropic (negative inotropic) activity in the series of crown ether derivatives.

[The effect of a crown-ether derivative, ethmozine and etatsizin on the functioning of the calcium pools in the guinea pig myocardium]. / Vliianie proizvodnogo kraun-éfira, étmozina i étatsizina na funktsionirovanie kal'tsevykh pulov v miokarde morskikh svinok.

Analysis of the component structure of single contractions of papillary muscles in guinea pigs was used to study the effects of the crown ether derivative benzylase-15-crown-5 and the antiarrhythmic agents ethmozine and ethacizine. The negative inotropic effect of these compounds was shown to be associated with limited penetration of calcium ions from the sarcolemmal pool into cardiac cellular myoplasm.

Investigation of antiischemic properties and mechanism of action of azacrown ether derivative.

The influence of the azacrown ether derivative benzylaza-15-crown-5 on myocardial tolerance to ischemia and on the functional state of the zone of myocardial ischemia during coronary artery occlusion was investigated in experiments on anaesthetized open-chest cats. The compound tested produced a dose-dependent antiischemic effect and prevented the development of myocardial ischemia. In experiments on isolated guinea-pig papillary muscle benzylaza-15-crown-5 inhibited the first and second components of the isoproterenol-induced muscle contraction. The compound decreased the maximal contraction force and had no effect on the cardiac cycle duration and on the time necessary for reaching maximal tension. It is suggested that the protective effect of benzylaza-15-crown-5 during myocardial ischemia is mediated through the inhibition of calcium release from the sarcoplasmic reticulum.

[The anti-ischemic properties of verapamil and its effect on myocardial functional potentials in coronary artery occlusion]. / Antiishemicheskie svoistva verapamila i ego vliianie na funktsional'nye vozmozhnosti miokarda pri okkliuzii koronarnoi arterii.

The effect of verapamil on the functional state of the ischemic myocardium, the myocardial tolerance to ischemia and the processes of urgent adaptation of the heart in the coronary artery occlusion was investigated in the experiments on anesthetized open-chest cats. Verapamil was shown to exert the dose-dependent anti-ischemic action, to increase the myocardial tolerance to ischemia, to suppress the response to the physiological saline infusion and not to change adrenoreactivity of the ischemic myocardium at the coronary artery compression.

[An experimental study of the cardio- and hemodynamic effects of the carboxyl ionophore monensin]. / Eksperimental'noe izuchenie kardio- i gemodinamicheskikh éffektov karboksil'nogo ionofora monensina.

The effect of ionophore monensin on the main parameters of cardio- and hemodynamics was studied in the experiments on anesthetized cats. Monensin (0.075-0.375 mg/kg) administered intravenously in the increasing doses was shown to produce the dose-dependent elevation of arterial blood pressure, the increase of myocardial contractility and the total peripheral resistance. A single administration of monensin (0.375 mg/kg) was found to exert the two-phase action on the parameters of cardio- and hemodynamics.

[Mechanism of the vascular action of verapamil and a crown ether derivative]. / Izuchenie mekhanizma sosudistogo deistviia verapamila i proizvodnogo kraun-éfirov.

The effects of verapamil and benzyl-aza-15-crown-5 on pressor reactions of blood pressure and perfusion pressure in the femoral artery after administration of noradrenaline, tyramine, angiotensin amide and stimulation of the femoral nerve were studied in acute experiments on anesthetized cats (pentobarbital sodium, 50 mg/kg). Verapamil (0.5 mg/kg) and benzyl-aza-15-crown-5 (9 mg/kg) suppressed pressor reactions to the nerve stimulation and produced no changes at administration of noradrenaline, tyramine and angiotensin amide. One can suggest that the mechanism of the vasodilating action of verapamil and benzyl-aza-15-crown-5 is due to their inhibitory effect on calcium-dependent release of noradrenaline from terminals of the sympathetic nerves. The search of vasodilating agents in the series of crown-ether derivatives is promising.

[Cardio- and hemodynamic effects of a crown ether derivative and an analysis of its cardiotropic action in an experiment]. / Kardio- i gemodinamicheskie éffekty proizvodnogo kraun-éfirov i analiz ego kardiotropnogo deistviia v éksperimente.

The cardio- and hemodynamic effects of the derivative of aza-15-crown-5 was studied in acute experiments on anesthetized (ethaminal sodium, 50 mg/kg) cats. At intravenous administration the compound was found to induce hypotension, to dilate arterial vessels, to exert negative ino- and chronotropic effects, to decrease the cardiac output. The pharmacological analysis suggests that the mechanism of the cardiotropic action of the compound is due to its intervention in calcium ion metabolism.

[Effect of tranquilizers on myocardial function in stress injury]. / Vliianie trankvilizatorov na funktsional'noe sostoianie moikarda pri ego stressornom povrezhdenii.

Experiments on rats were performed to evaluate the action of diazepam (1 mg/kg), phenazepam (1 mg/kg), meprotan (25 mg/kg), mebicar (500 mg/kg), and phenibut (25 mg/kg) on myocardial function under stress-induced injury. Diazepam, phenazepam and phenibut protected the myocardium from stress by raising the functional reserves of the heart. Meanwhile meprotan and mebicar produced no stress-protective action on the heart under similar conditions.

[Effect of tranquilizers on the course of myocardial ischemia and on myocardial resistance to hypoxia in coronary artery occlusion]. / Vliianie trankvilizatorov na techenie ishemii miokarda i na ustoichivost' miokarda k gipoksii pri okkliuzii koronarnoi arterii.

It was shown that meprobamate and phenazepam protect the myocardium from hypoxia and decrease myocardial ischemia during coronary occlusion. Phenibut and mebicar reduce the tolerance to ischemia and increase the degree of ischemic injury to the heart. Diazepam has no effect on these processes.