Subject(s)
Gas Chromatography-Mass Spectrometry/methods , Gastrointestinal Diseases/microbiology , Intestines/microbiology , Adolescent , Bacteria/classification , Bacteria/genetics , Bacteria/pathogenicity , Child , Fatty Acids/classification , Fatty Acids/genetics , Female , Gastrointestinal Diseases/diagnosis , Gastrointestinal Diseases/pathology , Humans , Intestines/pathology , Male , Microbiota/geneticsABSTRACT
AIM OF INVESTIGATION: To study quality of life (QL) peculiarities in children with chronic gastroduodenitis, Helicobacter pylori positive, in different stages of the disease. METHODS: Quality of life in 60 children (average age--13.06 +/- 1.2 years) with chronic gastroduodenitis was investigated with using adopted SF-36 questionnaire in period of exacerbation of the disease, in 6 weeks after treatment and in period of remission (in 6 months after treatment). 22 healthy children (average age--12.74 +/- 1.14 years) had been taken as a comparison group. RESULTS: Quality of life in children with chronic gastroduodenitis in exacerbation period was significantly worse (p < 0.05) than in healthy children. The more affected scores were the Role physical (RP), Bodily pain with the scores of healthy children. Presence astenic signs in period of remission (in 6 months after treatment) led to worsening of quality of life; the scores were the same and partly worse then before treatment. Applying of neurometabolic therapy improved psycho-emotional status and quality of life. CONCLUSIONS: Quality of life in children with chronic gastroduodenitis was changed with the period of diseases. Initially low scores had tendency to improvement after treatment. In remission period quality of life was mainly depended on peculiarities of psycho-emotional status. Astenic signs led to worsening of quality of life in children with remission of chronic gastroduodenitis. Neurometabolic treatment in this period improved both psycho-emotional status and quality of life.
Subject(s)
Gastroenteritis/psychology , Helicobacter Infections/psychology , Helicobacter pylori , Quality of Life , Adolescent , Child , Chronic Disease , Cohort Studies , Female , Gastroenteritis/physiopathology , Helicobacter Infections/physiopathology , Humans , Male , Pain Measurement , Surveys and QuestionnairesABSTRACT
Surgical treatment of complex congenital heart disease under extracorporeal circulation is accompanied by a systemic inflammatory reaction occurring in neonatal infants and babies. There were drastic increases in the concentration of tumor necrosis factor, interleukin-8, neutrophilic elastase and a predominance of a proinflammatory response over an inflammatory one at the warming stages and after administration of protamine sulfate. The rate of an inflammatory response depended on the duration of extracorporeal circulation. Modified ultrafiltration could remove cytokines; however, their concentration in the body remains high. A relationship was found between the course of a postoperative period and the rate of a developing reaction to extracorporeal circulation in the surgical treatment of congenital heart diseases.
