ABSTRACT
The paper gives data on the composition and strength characteristics and experimental and clinical findings of resolving antimicrobial suture materials, such as Capromed-type one, based on the modified caproic fiber coated by the biocompatible polymer PPB-1 which contains antimicrobial drugs. Capromed threads are demonstrated to have high strength characteristics and resolve in the body within 8-9 months. Coating the modified caproic fibers with the biocompatible copolymer imparts them pseudomonfilament characteristics and prevents the penetration of cellular elements to the thickness of threads. The content of antibacterial agents in the polymer coating confers prolonged antibacterial properties on Capromed. Desorption of antimicrobial agents from Capromed is conducive to more favourable healing, prevents the development of ligature fistulas, favours an over 4-fold reduction in the incidence of wound complications, as compared to the controls.
Subject(s)
Anti-Infective Agents/therapeutic use , Bacterial Infections/prevention & control , Postoperative Complications/prevention & control , Quinoxalines/therapeutic use , Sutures , Biocompatible Materials , Drug Combinations , Equipment Design , Humans , Nylons , Polymers , SolubilityABSTRACT
Experiments with male California rabbits were carried out different intervals of acute alcohol intoxication induced by intragastric administration of 40% ethanol solution in a dose of 10 ml/kg to examine daily changes of concentration of iron, alpha-tocopherol and lipid peroxidation products in the blood plasma from vena portal and vena hepatis. Acute alcohol intoxication was demonstrated to be accompanied by inversion in temporal organization of lipid peroxidation products, sideremia and alpha-tocopherol levels in the blood of vena hepatis. The invariability of the circadian rhythms of iron, alpha-tocopherol and lipid peroxidation products levels in vena portal blood a considered to prove participation of the liver in regulation of iron metabolism temporal organization in California rabbits with acute alcohol intoxication.
