ABSTRACT
Objetivo: Evaluación del impacto en la calidad de vida (CdV) relacionada con la salud en los pacientes con urticaria crónica espontánea en tratamiento con omalizumab. Método: Estudio observacional descriptivo longitudinal de calidad de vida partiendo de 18 pacientes con urticaria crónica espontánea ≥ 12 años tratados con omalizumab. Se analizaron los cambios en la CdV al mes (T1), a los 6 (T6) y a los 12 meses (T12), mediante: escala analógica visual (EVA), cuestionario de CdV específico de urticaria (CU-Q2oL), cuestionario de salud general (SF-36) y cuestionario de actividad de urticaria (Score UAS7). Resultados: Los síntomas más condicionantes para los pacientes fueron: prurito (61,1%); disminución de la salud y actividad física (55,5%); ronchas, hinchazón y nerviosismo (50%); depresión y vergüenza de marcas (38,89%); efectos secundarios a fármacos (33,33%); sueño y cansancio (27,78%); trabajo (22,22%); «elección de ropa y dolor» 16,67% y relaciones sociales (11,11%). Se observaron diferencias estadísticamente significativas en T1, T6 y T12. En T1, EVA -4,72 (p=0,001); CU-Q2oL -16,38 (p<0,001); SF-36 15,44 (p=0,006); UAS7 ronchas -7,27 (p=0,001), UAS7 prurito -8,72 (p=0,003). En T6, EVA -4,26 (p=0,001); CU-Q2oL -18,94 (p<0,001); SF-36 15,41 (p<0,001); UAS7 ronchas -7,41 (p=0,001), UAS7 prurito -7,11 (p=0,001). En T12 EVA -9,61 (p=0,004); CU-Q2oL -21,38 (p=0,01); SF-36 17,53 (p=0,04); UAS7 ronchas -8,23 (p=0,004), UAS7 prurito -10,69 (p=0,004). Conclusiones: Existió muy buena respuesta en T1, que se mantuvo en T6 y T12. Los pacientes con urticaria crónica espontánea tratados con omalizumab presentaron buenos resultados con reducción de la actividad de UCE y mejora de su CdV (AU)
Objective: Evaluation of the impact on the quality of life (QOL) relating to health in patients with chronic urticaria (CSU) treated with omalizumab. Method: Longitudinal descriptive observational study of quality of life based on18 patients with chronic urticaria ≥12 years treated with omalizumab. Changes in QOL examined at 1 month (T1), at 6 months (T6) and 12 months (T12), by: Visual Analogical Scale (UAS), specific urticaria QOL questionnaire (CU-Q2oL), general health questionnaire (SF-36) and activity of urticaria questionnaire (Score UAS7). Results: The most disabling symptoms for patients were: pruritus (61.1%); decrease in health and physical activity (55.5%), wheals, swelling and nervousness (50%); depression and shame of marks (38.89%); side effects to drugs (33.33%); sleepiness and tiredness (27.78%); work (22.22%); 'choosing clothes and pain' 16.67% and social relations (11.11%). Statistically significant differences were observed in T1, T6 and T12. In T1, UAS -4.72 (p=.001); CU-Q2oL -16.38 (p<.001); SF-36 15.44 (p=.006); UAS7 wheals -7.27 (p=.001), UAS7 pruritus -8.72 (p=.003). In T6, UAS -4.26 (p=.001); CU-Q2oL -18.94 (p<.001); SF-36 15.41 (p<.001); UAS7 wheals -7.41 (p=.001), UAS7 pruritus -7.11 (p=.001). In T12 UAS -9.61 (p=.004); CU-Q2oL -21.38 (p=.01); SF-36 17.53 (p=.04); UAS7 wheals -8.23 (p=.004), UAS7 pruritus -10.69 (p=.004). Conclusions: There was a very good response in T1, which was maintained in T6 and T12. Patients with chronic urticaria treated with omalizumab presented good results with a reduction of CUE activity and improvement of their QOL (AU)
Subject(s)
Humans , Male , Female , Adult , Urticaria/diagnosis , Urticaria/drug therapy , Quality of Life , Omalizumab/therapeutic use , Health Evaluation , Longitudinal StudiesABSTRACT
OBJECTIVE: Evaluation of the impact on the quality of life (QOL) relating to health in patients with chronic urticaria (CSU) treated with omalizumab. METHOD: Longitudinal descriptive observational study of quality of life based on18 patients with chronic urticaria ≥12 years treated with omalizumab. Changes in QOL examined at 1 month (T1), at 6 months (T6) and 12 months (T12), by: Visual Analogical Scale (UAS), specific urticaria QOL questionnaire (CU-Q2oL), general health questionnaire (SF-36) and activity of urticaria questionnaire (Score UAS7). RESULTS: The most disabling symptoms for patients were: pruritus (61.1%); decrease in health and physical activity (55.5%), wheals, swelling and nervousness (50%); depression and shame of marks (38.89%); side effects to drugs (33.33%); sleepiness and tiredness (27.78%); work (22.22%); "choosing clothes and pain" 16.67% and social relations (11.11%). Statistically significant differences were observed in T1, T6 and T12. In T1, UAS -4.72 (p=.001); CU-Q2oL -16.38 (p<.001); SF-36 15.44 (p=.006); UAS7 wheals -7.27 (p=.001), UAS7 pruritus -8.72 (p=.003). In T6, UAS -4.26 (p=.001); CU-Q2oL -18.94 (p<.001); SF-36 15.41 (p<.001); UAS7 wheals -7.41 (p=.001), UAS7 pruritus -7.11 (p=.001). In T12 UAS -9.61 (p=.004); CU-Q2oL -21.38 (p=.01); SF-36 17.53 (p=.04); UAS7 wheals -8.23 (p=.004), UAS7 pruritus -10.69 (p=.004). CONCLUSIONS: There was a very good response in T1, which was maintained in T6 and T12. Patients with chronic urticaria treated with omalizumab presented good results with a reduction of CUE activity and improvement of their QOL.
