[A model for the study of the ototoxic effects of drugs in an experiment]. / Model' dlia izucheniia ototoksicheskikh éffektov lekarstvennykh sredstv v éksperimente.

The authors compared sensitivity of the acoustic analyzer elements to ototoxic drugs in cat experiments. The model proposed assesses primary responses of the brain cortical acoustic zone (BCAZ) to sound stimulation. The drugs effect on the analyzer's periphery was determined from changes in bioelectric responses of the cochlea to sound stimulation (microphone potential, potential of the acoustic nerve action). The arguments are presented for feasibility of using primary BCAZ responses evoked by electric stimulation of thalamocortical radiation fibers coming from the medial geniculate body for examination of the drug effects on the analyzer's cortex. Parallel registration of the above bioelectrical reactions in the same animal for a long time makes it possible to compare sensitivity of different elements of the acoustic analyzer to ototoxic medication.

[Effects of furosemide on the excitability of the cerebral cortex]. / O vliianii furosemida na vozbudimost' kory golovnogo mozga.

The effect of furosemide on primary responses of the acoustic brain cortex of unrestrained cats was investigated. The responses were induced by electrical excitation of fibers of the thalamocortical radiation (TCR) and by sound excitation of various intensity and frequency. Furosemide at a dose of 18 mg/kg (intraperitoneally) did not modify primary responses to single stimulation of TCR fibers or their recovery. This diuretic produced an inhibitory effect on primary responses induced by sound excitation. Primary responses that developed in the acoustic cortex to sounds of a frequency of 10,000 Hz showed the highest sensitivity to furosemide. It was found that long-term (10 days) use of furosemide led to enhanced effects of the drug on primary responses to sound excitation.

[Our experience in the hyperbaric oxygenation treatment of patients with acute sensorineural hearing disorder of vascular etiology]. / Nash opyt lecheniia bol'nykh ostroi neirosensornoi tugoukhost'iu sosudistogo geneza s pomoshch'iu giperbaricheskoi oksigenatsii.

Forty patients with acute neurosensory hypoacusis of vascular genesis were exposed to combined treatment that included hyperbaric oxygenation (HBO) and drug therapy to improve microcirculation, vasodilation and metabolism. In order to control HBO side effects (vasoconstriction), the patients were subdivided into two subgroups of 20 subjects each. Group 1 patients were treated with HBO immediately before drug administration and Group 2 patients were treated with HBO immediately after drug administration. Good effects in Group 2 patients were twice as large. This was achieved by elimination of HBO side effects due to drug administration immediately before hyperbaric exposure.