[Experimental and clinical study of antibiotics administered intravitreally in endophthalmitis]. / Eksperimental'no-klinicheskoe izuchenie antibiotikov pri intravitreal'nom vedenii pri éndoftal'mitakh.

The concentrations of gentamicin and cefotaxime (claforan) in the humor of the anterior chamber and vitreous body of the eye were estimated in the study on the pharmacokinetics of the antibiotics in rabbits. The antibiotics were administered intravitreally in single doses. It was shown that the residence time of the antibiotics in the therapeutic concentrations in the eye cavity was 48 hours. Cefotaxime proved to be the most efficient agent in the prevention and treatment of postoperative endophthalmitis.

[Treatment of endophthalmitis with a single intravitreous administration of cefotaxime and gentamicin in an experiment]. / Lechenie éndoftal'mitov odnokratnym intravitreal'nym vvedeniem tsefotaksima i gentamitsina v éksperimente.

Experimental endophthalmitis was treated with single intravitreous administrations of cefotaxime (claforan) and gentamicin. It was found that a single administration of cefotaxime to the vitreous body prevented development of endophthalmitis in rabbits previously infected with Staphylococcus aureus, E. coli and Pseudomonas aeruginosa. Vitrectomy in the treatment of endophthalmitis was shown to be promising and provide satisfactory anatomical and functional results.

[T- and B-lymphocytes and their clinico-pathogenetic significance in patients with paranoid schizophrenia]. / Pokazateli T- i B-limfotsitov i ikh kliniko-patogeneticheskoe znachenie u bol'nykh paranoidnoi shizofreniei.

As many as 43 patients with first diagnosed paranoid schizophrenia running a shift-like course were examined for the blood counts of T and B lymphocytes with regard to the treatment conducted and disease standing. The patients received 3 types of the treatment: insulin, neuroleptics and combined treatment (insulin plus neuroleptics). During the treatment and after it, the content of B lymphocytes remained practically unchanged (p greater than 0.05) in all the patients. The content of T lymphocytes was reduced throughout the whole period of affliction with schizophrenia. However, during the combined treatment of the disease, a tendency towards increase of T cells was revealed, which coincided with the best clinical indicators.