Search | VHL Regional Portal

Urine antipyrine metabolites in rats with different resistance to hypoxia subjected to cold stress.

Grek, O R; Guseva, E O; Gichev, Y P; Sharapov, V I.

Bull Exp Biol Med ; 131(3): 227-8, 2001 Mar.

Article in English | MEDLINE | ID: mdl-11427903

ABSTRACT

We studied antipyrine metabolism in rats with different resistance to hypoxia during adaptation to cold stress. Changes in the concentrations of some antipyrine metabolites at low temperature were associated with individual resistance to hypoxia. In low-resistant rats, antipyrine metabolism was suppressed from day 5 of cold exposure to day 3 of the recovery period. In highly resistant rats, antipyrine metabolism was inhibited on day 3 of cold exposure, but returned to normal on day 3 of the recovery period.

Subject(s)

Adaptation, Physiological , Antipyrine/urine , Cold Temperature , Hypoxia/physiopathology , Stress, Physiological/urine , Animals , Male , Rats , Rats, Wistar , Stress, Physiological/physiopathology

[A comparative assessment of the biotransformational and pharmacokinetic activities of the liver in inhabitants of the tropics and middle latitudes during adaptation in the Polar region]. / Sravnitel'naia otsenka biotransformatsionnoi i farmakokineticheskoi aktivnosti pecheni u zhitelei tropikov i srednikh shirot pri adaptatsii v Zapoliar'e.

Gichev, Iu P; Guseva, E O.

Fiziol Cheloveka ; 24(6): 103-7, 1998.

Article in Russian | MEDLINE | ID: mdl-9929961

Subject(s)

Adaptation, Physiological , Cold Climate , Liver/enzymology , Tropical Climate , Anti-Inflammatory Agents, Non-Steroidal/analysis , Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics , Antipyrine/analysis , Antipyrine/pharmacokinetics , Biotransformation/physiology , Cytochrome P-450 Enzyme System/metabolism , Half-Life , Humans , India/ethnology , Russia , Saliva/chemistry , Seasons , Time Factors

[Antipyrine pharmacokinetics in rats with various resistance to hypoxia during cold stress]. / Farmakokinetika antipirina u krys s razlichnym tipom ustoichivosti k gipoksii pri kholodovom stresse.

Gichev, Iu P; Guseva, E O; Grek, O P; Sharapov, V I.

Biull Eksp Biol Med ; 126(11): 513-5, 1998 Nov.

Article in Russian | MEDLINE | ID: mdl-9883356

Subject(s)

Antipyrine/pharmacokinetics , Cold Temperature , Hypoxia/metabolism , Stress, Physiological/metabolism , Acute Disease , Animals , Hypoxia/complications , Male , Rats , Rats, Wistar , Species Specificity , Stress, Physiological/complications

[Biotransformation of xenobiotics in the liver of rats with different resistance to hypoxia during exposure to cold]. / Biotransformatsiia ksenobiotikov v pecheni pri kholodovom vozdeistvii u krys s razlichnoi ustoichivost'iu k gipoksii.

Grek, O R; Gichev, Iu P; Guseva, E O; Sharapov, V I.

Biull Eksp Biol Med ; 126(12): 631-3, 1998 Dec.

Article in Russian | MEDLINE | ID: mdl-9934504

Subject(s)

Adaptation, Physiological , Cold Temperature , Hypoxia/physiopathology , Liver/enzymology , Xenobiotics/pharmacokinetics , Animals , Biotransformation , Male , Rats , Rats, Wistar

ABSTRACT

Subject(s)

Subject(s)

Subject(s)

Subject(s)

SEND TO:

SELECTION OF CITATIONS

SEARCH DETAIL