[The role of the killer activity of the peripheral blood lymphocytes in the pathogenesis of rheumatism]. / Rol' killernoi aktivnosti limfotsitov perifericheskoi krovi v patogeneze revmatizma.

A total of 49 patients with rheumatism running a sluggish course, were examined, as were those with decompensated tonsillitis, systemic lupus erythematosus, and 20 essentially healthy subjects. In inactive rheumatism an increase in the killer activity of lymphocytes and augmentation of amounts of Fc+lymphocytes were revealed, which values were significantly different from those in the other groups. The detected changes in the activity of lymphocytes may serve as differential-diagnostic criteria.

[The relationship between respiratory system reactivity and neutrophil metabolism in hypoxia in persons subjected to ionizing radiation exposure]. / Vzaimosviaz' mezhdu reaktivnost'iu sistemy dykhaniia i metabolizmom neitrofilov pri gipoksii u lits, podvergshikhsia vozdeistviiu ioniziruiushchego izlucheniia.

The group of 18 men exposed to radiation during amelioration work in the Chernobyl NPP was examined in the course of adaptation to intermittent hypoxia (rebreathing technique during 10 days of three daily 5-7 min sessions with 15 min break). The starting level of ventilatory response to hypoxic stimulus (HVR) did not differ from the one in persons living in non-contaminated areas. This hypoxic training (HT) caused the increase of HVR, activity of NADPH-oxidase and cationic protein content in neutrophils as well as various changes in myeloperoxidase activity. The correlation between respiration reactivity and deviations in neutrophil metabolism under HT was found.

[The characteristics of infectious immunosuppression in patients with benign subleukemic myelosis]. / Osobennosti infektsionnoi immunosuppressii u bol'nykh dobrokachestvennym subleikemicheskim mielozom.

Sixty-five patients with subleukemic myelosis (SLM) during the stage of advanced clinical manifestations were evaluated for parameters characterizing immunologic reactivity. Infectious- inflammatory processes in SLM were found out to develop in the presence of immunity deficiency manifested by the depression of T-and phagocytic link of immunity. Superimposed infection in this pathology promotes further depression of T-link of immunity as well as activation of those cellular parameters characterizing the nonspecific defence.

[Changes in the T-cell component in patients with subleukemic myelosis at various stages of the pathologic process]. / Izmeneniia T-kletochnogo zvena immuniteta u bol'nykh subleikemicheskim mielozom na razlichnykh stadiiakh patologicheskogo protsessa.

T-cell immunity was assessed in 111 patients with subleukemic myelosis. In such patients with large tumor mass and leukemia exacerbation the amount of immunocompetent cells and their functional activity were reduced more prominently. Association of infection and inflammation promoted aggravation of initial immune deficiency.

[The activity of natural and antibody-dependent leukocyte cytotoxicity in lympholeukemia and multiple myeloma]. / Aktivnost' estestvennoi i antitelozavisimoi tsitotoksichnosti leikotsitov pri limfoleikoze i mielomnoi bolezni.

A study was made of cytotoxic activity of lymphocytes and neutrophils in the peripheral blood of 16 patients with advanced stage Kahler's disease, 4 patients in terminal stage, 14 patients with advanced stage chronic lymphoid leukosis, and 6 patients in the terminal stage disease. It has been shown that the level of cytotoxic activity of leucocytes in tumor diseases on the immunity B-system is a criterion for the extent to which the tumor process has been disseminated.

[The role of the neutrophil link in phagocytosis in the pathogenesis of suppurative inflammatory complications in chronic myeloleukemia]. / Rol' neitrofil'nogo zvena fagotsitoza v patogeneze gnoino-vospalitel'nykh oslozhnenii khronicheskogo mieloleikoza.

An evaluation was done of parameters of neutrophilic link of fagocytosis in 177 patients with chronic myeloleukemia during the course of the illness. All parameters characterizing the phagocyte reaction got reduced compared to normal findings, with the chronic myeloleukemia patients presenting with great size tumors manifesting somewhat more apparent reduction. Pyo-inflammatory processes were found to be most common among those persons presenting with manifest suppression of the phagocytosis function.

[Clinico-immunologic effect of tactivin in chronic myeloid leukemia]. / Kliniko-immunologicheskii éffekt taktivina pri khronicheskom mieloleikoze.

Immunological reactivity and factors of nonspecific body defense were studied in 35 patients with advanced chronic myeloid leukemia (CML). Prior to cytostatic therapy, CML patients have secondary combined immunodeficiency manifesting by inhibition of T-system immunity and phagocytic neutrophil activity. Repeated courses of myelosan chemotherapy aggravate the above immune defects. The adjuvant immunomodulator tactivin corrects cellular immunity and reduces the occurrence of infectious complications 1.77-fold.

[Effect of tactivin on cytotoxicity of blood lymphocytes in chronic myeloproliferative diseases]. / Vliianie taktivina na tsitotoksichnost' limfotsitov krovi pri khronicheskikh mieloproliferativnykh zabolevaniiakh.

The author studied natural cellular cytotoxicity (NCC) and antibody-dependent cytotoxicity (ADC) in lymphocytes from 31 patients with chronic myeloid leukemia (CML) and 37 patients with subleukemic myeloleukemia (SLM) in active clinical stage. The above parameters were found low in both diseases. Cytostatic therapy for CML did not affect NCC, but inhibited ADC. SLM treatment with myelobromol inhibited both cytotoxic responses. Combined therapy with adjuvant tactivin stimulated cytotoxic reactions activity. Tactivin positive effects persisted for two months.

[The effect of heparin in vasorenal hypertension on blood electrolyte balance, on the abdominal aortic walls and on the erythrocyte rheological properties in rats]. / Vliianie geparina pri vazorenal'noi gipertenzii na balans élektrolitov krovi i stenki briushnoi aorty i reologicheskie svoistva éritrotstov krys.

The paper provides the results of experimental studies of the effects of heparin given to albino rats with vasorenal hypertension in a dose of 150 U/kg on electrolyte levels in plasma, erythrocytes, cardiac and abdominal aortic tissues, the viscosity coefficient and charge of erythrocytic suspension, transmural difference of abdominal aortic potentials. Heparin has been shown to correct hypertension-induced changes in the transmural difference of abdominal aortic potentials, the charge and viscosity coefficient of erythrocytic suspension, the gradient of sodium, potassium, and calcium in the system of erythrocyte-plasma-abdominal aortic wall.

[The effect of different types of immunocorrective therapy on the clinical course of chronic myeloleukemia]. / Vliianie razlichnykh vidov immunokorrigiruiushchei terapii na klinicheskoe techenie khronicheskogo mieloleikoza.

Influence of various patterns of immunocorrective therapy on clinical course of chronic myeloleukemia (CML) was studied. It was shown that combinations of drugs with different pharmacological effects provide more than 5-fold decrease in incidence of infection-related complications and promote rapid recovery from infections during antibacterial treatment.

[Pathogenetic mechanisms in the onset of infectious complications in chronic myeloid leukemia]. / Patogeneticheskie mekhanizmy vozniknoveniia infektsionnykh oslozhneniipri khronicheskom mieloleikoze.

Out of 177 patients with advanced chronic myeloid leukemia infectious complications developed in 23.66%. The chief reason for emergence of bacterial processes in chronic myeloid leukemia is attributed to qualitative and quantitative insufficiency of phagocytizing and immunocompetent cells provoking disturbance of cooperative interaction between lymphocytes and neutrophils.

[The role of natural killer cell activity in the pathogenesis of chronic myeloproliferative diseases]. / Rol' aktivnosti estestvennykh killernykh kletok v patogeneze khronicheskikh mieloproliferativnykh zabolevanii.

The study of natural killers' (NK) activity was carried out in 114 patients with myelo-proliferative diseases (MPD). Fall of NK-activity was found in all patients. Chronic myeloleukemia was associated with the most considerable decrease of blood leukocytes' cytotoxicity. Patents with gross tumorous mass and exacerbation of leukemic process revealed reduced NK activity as compared to those with low mass of tumor and stable leukemia.

[Differential diagnostic criteria in chronic myeloproliferative diseases]. / Differentsial'no-diagnosticheskie kriterii khronicheskikh mieloproliferativnykh zabolevanii.

A study of functional activity of segmentonuclear neutrophil granulocytes of the peripheral blood in 20 patients with subleukemic myelosis (SLM) and 20 patients with polycythemia vera (PV) revealed in the latter an increase of the functional activity of phagocytosis, oxygen-dependent metabolism and enzymatic activity were more pronounced than in SLM. Nonhomogeneity of morphological and cytochemical indices and patients with SLM and IP may be used as supplementary differential diagnostic criterion in SLM and IP.

[Suppressive effect of circulating immune complexes on cytotoxicity of blood lymphocytes in patients with chronic myeloid leukemia]. / Supressivnoe deistvie tsirkuliruiushchikh immunnykh kompleksov na tsitotoksichnost' limfotsitov krovi bol'nykh khronicheskim mielo- leikozom.

Concentration of circulating immune complexes (CIC) and cytotoxicity (natural and antibody-dependent) of blood lymphocytes were studied in 52 patients at the developed stage of chronic myeloid leukemia (CML). Elevation of CIC level and reduction of cytotoxicity detectable in all CML patients were most manifest in those with high tumor mass and during exacerbation of the leukemia process. A conclusion has been made that CIC are suppressors of natural and antibody-dependent cytotoxicity of blood lymphocytes in CML patients.

[The characteristics of the humoral interaction of lymphocytes with neutrophilic granulocytes of the peripheral blood in patients with chronic lympholeukemia under the influence of Proper-Myl]. / Osobennosti gumoral'nogo vzaimodeistviia limfotsitov s neitrofil'nymi granulotsitami perifericheskoi krovi u bol'nykh khronicheskim limfoleikozom pod vliianiem proper-mila.

A study of 32 patients with chronic lympholeucosis (CL) revealed a reduction of the number of phagocytosing neutrophil granulocytes and a reduction of production of humoral mediators by lymphocytes that stimulated the phagocytic function of granulocytes. It is shown that treatment by usually used cytostatic agents did not essentially effect the investigated values. Inclusion of proper-myl in the treatment course of patients with chronic lympholeucosis furthered increase of the number of phagocytosing neutrophil granulocytes and an increased production of humoral mediator stimulating the phagocytic activity of granulocytes.

[Use of the stimulants of nonspecific resistance in the complex treatment of infectious complications in patients with chronic myeloid leukemia]. / Primenenie stimuliatorov nespetsificheskoi rezistentnosti organizma v kompleksnom lechenii infektsionnykh oslozhnenii u bol'nykh khronicheskim mieloleikozom.

Effectiveness of three methods of infectious complication therapy in chronic myeloleukemia (CML) patients was studied. Group I patients (n = 20) received antibiotics, group II patients (n = 9) were given antibiotics with gamma-globulin, in group III antibiotics combined with individually selected immunomodulators were used. The highest effect was recorded in CML patients who received antibiotics combined with the immunomodulators that has led to normalization of cellular and humoral factors of nonspecific body resistance.