ABSTRACT
A growing morbidity among the population of the Maritime territory is preconditioned by a worsening social-and-economic situation, and by a sharply falling purchasing capacity of people, which had an absolutely negative effect on the structure of foodstuffs consumption. The qualitatively and quantitatively insufficient nutrition predetermines a deficit of macro- and micronutrient composition of daily ration and its value. Such defects of nutrition have a pronounced negative influence on the population's health and predetermine a high level of diseases of the digestive apparatus.
Subject(s)
Energy Intake/physiology , Gastrointestinal Diseases/epidemiology , Health Status , Nutritional Status , Adult , Catchment Area, Health , Female , Food/standards , Gastrointestinal Diseases/etiology , Humans , Male , Public Health , Rural Population/statistics & numerical data , Russia/epidemiology , Urban Population/statistics & numerical dataABSTRACT
The effect of SD-6, a 3-hydroxypyridine antioxidant, on the pattern of variation in contraction intensity, contracture and membrane potentials were assessed in experimental studies on isolated left ventricular papillary muscles of rats, exposed to hypoxia and reoxygenation. The antioxidant considerably limited hypoxic and reperfusion contracture, its efficiency increasing with a concentration reduced to 10(-7) g/ml. Contraction intensity and duration of action potentials, diminished by hypoxia, were only recovered by reoxygenation, if the antioxidant was present. It is assumed that the recovery of action potentials by reoxygenation in the presence of SD-6 may result from normalization of ATP-dependent outgoing current through the kappa channels, activated by ATP deficiency. The antioxidant capacity for levelling diverse durations of action potentials between normal and ischemic areas is evidence of an important contribution of free-radical mechanisms to the development of reoxidation-induced recirculation arrhythmias.
Subject(s)
Antioxidants/pharmacology , Heart/drug effects , Hypoxia/physiopathology , Myocardial Contraction/drug effects , Oxygen Consumption/drug effects , Picolines/pharmacology , Pyridines/pharmacology , Animals , Dose-Response Relationship, Drug , In Vitro Techniques , Membrane Potentials/drug effects , Myocardium/metabolism , Papillary Muscles/drug effects , RatsABSTRACT
A comparative analysis was performed of changes in the contractile and electrical activity of the rat myocardium in experiments on isolated papillary muscles, obtained 2-2.5 months after the discontinuation of chronic administration of rubomicin in 0.7 mg/kg and ruboxil in 3 mg/kg dose to the animals. It is shown that rubomicin decreases the maximal rate of growth of the anterior potential of action and in a greater degree than ruboxil inhibits the contractile activity of papillary muscles. The preparations had a contrary influence on the rhythmoinotropic relations in the rat myocardium. This difference might be connected with the ability of rumobimicin to block and of ruboxil to stimulate Na-Ca metabolism. The participation of these mechanisms in the process of development of cardiotoxicity of antracycline antibiotics is discussed.
