[Age-related changes in the autonomic ganglia]. / Vozrastnye izmeneniia vegetativnykh gangliev.

Ultrastructure of vegetative ganglions (neck-thoracic, intracardial and intestinal) of Wistar and SHR rats, 26-28 months of age was studied electron-microscopically. The most pronounced changes were found in the neck-thoracic ganglions where, apart from lipofuscin deposits, lamellar bodies were frequently found. Redistribution of neuromediators in the neuron body and an increase of the neuroactive substances release into the intercellular space of the ganglion occur with age. The data on possible postsynaptic influence on the presynapse by means of neuromediators are presented. Nissl bodies hypertrophy was observed in the neck-thoracic and intracardial ganglions of old SHR rats.

[Interneuronal interrelationships in autonomic ganglia (the ultrastructural aspects)]. / Mezhneironnye vzaimootnosheniia v vegetativnykh gangliiakh (ul'trastrukturnye aspekty).

Ultrastructural and immunocytochemical results of studies on interneuronal relationship in vegetative ganglia were represented. Age-related changes of synapses (appearance of synaptic type vesicles and smooth endoplasmic reticulum cisterns in postsynaptic terminals), peculiarities of interneuronal links in neurons containing neuropeptide Y and NO-synthase and structural manifestations of non-synaptic interneuronal links were shown. Modern views on interneuronal communications were discussed.

[Nitric oxide synthase in neuroepithelial brain tumors]. / Sintaza okisi azota v neiroépitelial'nykh opukholiakh golovnogo mozga.

Immunohistochemical investigation of NO-synthase in brain astrocytic tumors revealed intense reaction in many tumor cells as well as direct correlation in the intensity of reaction and the degree of tumor anaplasia. Grade I astrocytomas did not show immunoreactivity in contrast to high anaplastic tumors where many cells had positive reaction with a different degree of intensity. Positive immunoreaction was shown in many giant cells. Small cell glioblastomas and oligodendrogliomas were immunonegative. There was a direct correlation between NO-synthase expression and glial fibrillar acidic protein.

[Ultrastructure of neurons of the human sympathetic ganglia after sudden death (morphometric study)]. / Ul'trastruktura neironov simpaticheskikh gangliev cheloveka pri vnezapnoi smerti (morfometricheskoe issledovanie).

Six cases of urgent autopsies after a sudden cardiac death (SCD) of persons at the age 40-60 years and 5 control cases have been investigated. Osmiophilic mitochondria with inclusions make 1% of the whole neuronal cytoplasm volume. If we take all mitochondria as 100%, volumetric density of mitochondria with osmiophilic inclusions makes 9.6%. Volumetric density of mitochondria at SCD in comparison with the control is significantly higher in connection with increase of their size. In other components of cytoplasm, in particular in lysosomes and lipofuscin, no changes are revealed.

[Ultrastructural-morphometric study of cardiac myocytes in the cell culture]. / Ul'trastrukturno-morfometricheskoe issledovanie myshechnykh kletok serdtsa krys v kul'ture.

Ultrastructural-morphometric studies of the right and left heart ventricles of 4-day young rat were carried out during 7-day cultivation to examine morphologic and sterologic parameters of mitochondria and myofibrils. The morphometric data demonstrated a recurrent character of mitochondria and myofibril structural changes. The changes occurred should not be regarded as structural cell differentiations but rather as adaptation to the cultivation conditions.