Effects of Age on Cross-Cultural Differences in the Neural Correlates of Memory Retrieval.

Culture can shape memory, but little research investigates age effects. The present study examines the neural correlates of memory retrieval for old, new, and similar lures in younger and older Americans and Taiwanese. Results show that age and culture impact discrimination of old from new items. Taiwanese performed worse than Americans, with age effects more pronounced for Taiwanese. Americans activated the hippocampus for new more than old items, but pattern of activity for the conditions did not differ for Taiwanese, nor did it interact with age. The engagement of left inferior frontal gyrus (LIFG) differed across cultures. Patterns of greater activity for old (for Americans) or new (for Taiwanese) items were eliminated with age, particularly for older Americans. The results are interpreted as reflecting cultural differences in orientation to novelty vs. familiarity for younger, but not older, adults, with the LIFG supporting interference resolution at retrieval. Support is not as strong for cultural differences in pattern separation processes. Although Americans had higher levels of memory discrimination than Taiwanese and engaged the LIFG for correct rejections more than false alarms, the patterns of behavior and neural activity did not interact with culture and age. Neither culture nor age impacted hippocampal activity, which is surprising given the region's role in pattern separation. The findings suggest ways in which cultural life experiences and concomitant information processing strategies can contribute to consistent effects of age across cultures or contribute to different trajectories with age in terms of memory.

The role of culture and semantic organization in working memory updating.

Westerners tend to relate items in a categorical manner, whereas Easterners focus more on functional relationships. The present study extended research on semantic organization in long-term memory to working memory. First, Americans' and Turks' preferences for categorical versus functional relationships were tested. Second, working memory interference was assessed using a 2-back working memory paradigm in which lure items were categorically and functionally related to targets. Next, a mediation model tested direct effects of culture and semantic organization on working memory task behaviour, and the indirect effect, whether semantic organization mediated the relationship between culture and working memory interference. Whereas Americans had slower response times to correctly rejecting functional lures compared to categorical lures, conditions did not differ for Turks. However, semantic organization did not mediate cultural difference in working memory interference. Across cultures, there was evidence that semantic organization affected working memory errors, with individuals who endorsed categorical more than functional pairings committing more categorical than functional errors on the 2-back task. Results align with prior research suggesting individual differences in use of different types of semantic relationships, and further that literature by indicating effects on interference in working memory. However, these individual differences may not be culture-dependent.

How False Memory and True Memory Affect Decision Making in Older Adults: A Dissociative Account.

OBJECTIVES: Remembering past rewarding experiences plays a crucial rule in guiding people's decision making in the future. However, as people age, they become less accurate in remembering past events and more susceptible to forming false memories. An important question is how the decline of episodic memory and the increase of false memory may affect older adults' decision-making performance. METHODS: The current study used a newly developed paradigm in which the Deese-Roediger-McDermott (DRM) false memory paradigm was combined with a reward learning task to create robust false memories of rewarding experiences. Participants learned that some DRM picture lists brought them a monetary reward and some DRM picture lists did not bring reward. Later, their memories were tested and decision-making preferences were measured. RESULTS: We found that older and younger adults had almost equivalent false and true memories under the rewarding context, but older adults showed significantly lower decision-making preferences for lure pictures and rewarded pictures than younger adults. Furthermore, true and false memories were a stronger predictor of decision-making preferences for younger than for older adults. DISCUSSION: These results together suggest an age-related dissociation between memory and decision making that older adults may be less efficient in using their memory to guide decision making than younger adults. Future research may further investigate its underlying mechanisms and develop potential interventions aiming at strengthening the connection between memory and decision making in older adults to help improve their decision-making performance.

Culture, prefrontal volume, and memory.

Prior cross-cultural studies have demonstrated differences among Eastern and Western cultures in memory and cognition along with variation in neuroanatomy and functional engagement. We further probed cultural neuroanatomical variability in terms of its relationship with memory performance. Specifically, we investigated how memory performance related to gray matter volume in several prefrontal lobe structures, including across cultures. For 58 American and 57 Taiwanese young adults, memory performance was measured with the California Verbal Learning Test (CVLT) using performance on learning trial 1, on which Americans had higher scores than the Taiwanese, and the long delayed free recall task, on which groups performed similarly. MRI data were reconstructed using FreeSurfer. Across both cultures, we observed that larger volumes of the bilateral rostral anterior cingulate were associated with lower scores on both CVLT tasks. In terms of effects of culture, the relationship between learning trial 1 scores and gray matter volumes in the right superior frontal gyrus had a trend for a positive relationship in Taiwanese but not in Americans. In addition to the a priori analysis of select frontal volumes, an exploratory whole-brain analysis compared volumes-without considering CVLT performance-across the two cultural groups in order to assess convergence with prior research. Several cultural differences were found, such that Americans had larger volumes in the bilateral superior frontal and lateral occipital cortex, whereas Taiwanese had larger volumes in the bilateral rostral middle frontal and inferior temporal cortex, and the right precuneus.

Influence of acculturation and cultural values on the self-reference effect.

Cultural milieu can influence the way information is processed and what strategies are employed to deal with ever-changing environments. This study assessed whether acculturation and cultural values of East Asians can affect memory, with a specific focus on the self-reference effect in Chinese international students. Participants encoded and retrieved adjectives, with some trials relating the words to the self (i.e., the self-referencing task), another person, or a control condition; participants also completed questionnaires assessing cultural adaptation and self-construal. Results did not show a relationship between acculturation orientation and self-construal and the magnitude of the self-reference effect in memory, defined as better memory for adjectives encoded related to the self compared to those related to close others, in this sample of Chinese international students. Future research should explore effects of acculturation over time, incorporating more heterogeneous samples and sensitive neural measures.

Cross-cultural comparison of the neural correlates of true and false memory retrieval.

Prior work has shown Americans have higher levels of memory specificity than East Asians. Neuroimaging studies have not investigated mechanisms that account for cultural differences at retrieval. In this study, we use fMRI to assess whether mnemonic discrimination, distinguishing novel from previously encountered stimuli, accounts for cultural differences in memory. Fifty-five American and 55 Taiwanese young adults completed an object recognition paradigm testing discrimination of old targets, similar lures and novel foils. Mnemonic discrimination was tested by comparing discrimination of similar lures from studied targets, and results showed the relationship between activity in left fusiform gyrus and behavioural discrimination between target and lure objects differed across cultural groups. Parametric modulation analyses of activity during lure correct rejections also indicated that groups differed in left superior parietal cortex response to variations in lure similarity. Additional analyses of old vs. new activity indicated that Americans and Taiwanese differ in the neural activity supporting general object recognition in the hippocampus, left inferior frontal gyrus and middle frontal gyrus. Results are juxtaposed against comparisons of the regions activated in common across the two cultures. Overall, Americans and Taiwanese differ in the extent to which they recruit visual processing and attention modulating brain regions.

Do cultural differences emerge at different levels of representational hierarchy?

In prior research, Eastern and Western culture groups differ in memory specificity for objects. However, these studies used concrete object stimuli, which carry semantic information that may be confounded with culture. Additionally, the perceptual properties of the stimuli were not tightly controlled. Therefore, it cannot be precisely determined whether the observed cross-cultural differences are generalizable across different stimulus types and memory task demands. In prior studies, Americans demonstrated higher memory specificity than East Asians, but this may be due to Americans being more attuned to the low-level features that distinguish studied items from similar lures, rather than general memory differences. To determine whether this pattern of cross-cultural memory differences emerges irrespective of stimulus properties, we tested American and East Asian young adults using a recognition memory task employing abstract stimuli for which attention to conjunctions of features was critical for discrimination. Additionally, in order to more precisely determine the influence of stimulus and task on culture differences, participants also completed a concrete objects memory task identical to the one used in prior research. The results of the abstract objects task mirror the pattern seen in prior studies with concrete objects: Americans showed generally higher levels of recognition memory performance than East Asians for studied abstract items, whether discriminating them from similar or entirely new items. Results from the current concrete object task generally replicated this pattern. This suggests cross-cultural memory differences generalize across stimulus types and task demands, rather than reflecting differential sensitivity to low-level features or higher-level conjunctions.

Memory and aging across cultures.

Memory declines are commonly reported with age, but the majority of research has been conducted with narrow segments of the world's population. We argue for the importance of considering culture in the study of cognitive aging in order to have a representative, accurate understanding of the effects of aging on memory. Limited research thus far investigates the effects of culture on the use of categories and the self in memory with age, finding that cultural differences tend to be larger for older than younger adults. Frameworks drawing on top-down and bottom-up processes may account for when more or less cultural variation would be expected in cognitive performance. Promising future research directions include socio-emotional memory and expanding samples to address global inequities.

Individual Differences in Older Adult Frontal Lobe Function Relate to Memory and Neural Activity for Self-Relevant and Emotional Content.

OBJECTIVES: Older adults show memory benefits for self-relevant and emotional content, but there are individual differences in this effect. It has been debated whether processing of self-relevant and emotional information relies on similar processes to one another. We examined whether variation in frontal lobe (FL) function among older adults related similarly to the processing of self-relevant information as it did to emotional information, or whether these relations diverged. METHODS: While undergoing fMRI, participants (ages 60-88) viewed positive, negative, and neutral objects, and imagined placing those objects in either their home or a stranger's home. Participants completed a surprise memory test outside of the MRI. In a separate session, a cognitive battery was collected and composite scores measuring FL and medial temporal lobe function were computed and related to the behavioral memory performance and the neural engagement during fMRI. RESULTS: Behaviorally, FL function related to memory for self-relevant, but not emotional content. Older adults with higher FL function demonstrated reduced self-bias in memory performance. During the processing of self-relevant stimuli, independent of emotion, levels of activity in the middle frontal gyrus showed positive associations with FL function. This relationship was not driven by compensatory activity or disruptions to nonself-relevant neutral content. DISCUSSION: These findings point to divergence in the cognitive functions relating to memory enhancements for self- and emotional-relevance. The results further suggest self-relevance as a mnemonic device for older adults, especially in those with lower FL function.

The Role of Autobiographical Resilience Memories in Emotion Regulation: An Account of Age Differences in Mnemonic and Positive Reappraisal.

A lifetime of resilience through emotionally challenging experiences may benefit older adults, lending to emotion regulation mastery with time. Yet the influence of autobiographical experiences on momentary reappraisal, the reinterpretation of negative stimuli as more positive, has never been empirically tested. This online study examined the extent to which associating life memories of resilience with novel negative scenarios enhanced reappraisal efficacy and reduced difficulty to reappraise. Younger and older adults reappraised negative images by associating reappraisals to freely selected autobiographical resilience memories, cued autobiographical resilience memories, or by finding situational silver linings without mnemonic association (control). Changes in image emotional intensity ratings revealed no difference across reappraisal conditions for younger adults, while older adults most effectively down-regulated emotional intensity using the control reappraisal strategy. Older adults found autobiographical memories more helpful for mood regulation and less difficult to implement, and identified greater similarities between novel negative scenarios and their memories than younger adults. Surprisingly, greater similarity between resilience memories and negative images was associated with lower reappraisal efficacy for both age groups. Findings demonstrate the age-equivalent benefits of utilizing reappraisals associated with past narratives of resilience and suggest a sacrifice of immediate hedonic benefit for disproportionately greater subjective benefits with age.

Empathy, memory, and aging during the COVID-19 pandemic.

Recently, there has been increasing attention to the interaction between empathy and memory. During the COVID-19 pandemic, a period when empathy played a key role in people's behaviors, we assessed the relationship between empathy and memory. In this pre-registered report, we used memory accuracy for the number of COVID-19 cases as a measure of recent memory and examined its relationship with trait empathy. Moreover, we investigated whether cognitive vs. affective empathy differently associate with one's memory for the number of COVID-19 cases, given evidence for distinct mechanisms for the two aspects of empathy. Finally, we assessed how age is related to empathy-memory associations. To address these questions, we used the Boston College COVID-19 Dataset, which included surveys assessing dispositional empathy and memory for the number of confirmed COVID-19 cases during the first wave of the pandemic. Empathy was not associated with memory accuracy for the confirmed cases when using an empathy measure that combined both cognitive and affective empathy. However, when using a measure that separately assessed cognitive and affective empathy, only affective empathy, specifically the personal distress subscale, was associated with greater memory accuracy. There was no age-related difference in memory accuracy despite age-related decreases in affective empathy. Results suggest that individuals with greater affective empathy (i.e., greater tendency to feel discomfort by the suffering of others) can have more accurate memory for details of an ongoing empathy-evoking situation. Findings are discussed in the context of motivation and emotional arousal. The current study provides ecological evidence to corroborate the interplay of empathy and memory.

Consideration of culture in cognition: How we can enrich methodology and theory.

In this paper, we argue that adopting an inclusive approach where diverse cultures are represented in research is of prime importance for cognitive psychology. The overrepresentation of participant samples and researchers from WEIRD (Western, Educated, Industrialized, Rich, and Democratic) cultures limits the generalizability of findings and fails to capture potential sources of variability, impeding understanding of human cognition. In an analysis of articles in representative cognitive psychology journals over the five-year period of 2016-2020, we find that only approximately 7% of articles consider culture, broadly defined. Of these articles, a majority (83%) focus on language or bilingualism, with small numbers of articles considering other aspects of culture. We argue that methodology and theory developed in the last century of cognitive research not only can be leveraged, but will be enriched by greater diversity in both populations and researchers. Such advances pave the way to uncover cognitive processes that may be universal or systematically differ as a function of cultural variations, and the individual differences in relation to cultural variations. To make a case for broadening this scope, we characterize relevant cross-cultural research, sample classic cognitive research that is congruent with such an approach, and discuss compatibility between a cross-cultural perspective and the classic tenets of cognitive psychology. We make recommendations for large and small steps for the field to incorporate greater cultural representation in the study of cognition, while recognizing the challenges associated with these efforts and acknowledging that not every research question calls for a cross-cultural perspective.

Intent-Based Moral Judgment in Old Age.

OBJECTIVES: Recent studies support the idea of an intent-to-outcome shift in moral judgments with age. We further assessed whether a reduced reliance on intentions is associated with aging in a preregistered study with 73 younger (20-41 years) and 79 older (70-84 years) adults, group-matched on education level. METHOD: Participants were presented with a set of moral cases to evaluate, created by varying orthogonally the valence (neutral, negative) of the information regarding the agent's intentions and the action's outcomes. RESULTS: The two age groups did not differ in the extent they relied on intentions in moral judgment. DISCUSSION: These results suggest that an intent-to-outcome shift might not be found in all aging populations, challenging prevailing theories suggesting that aging is necessarily associated with a reduced reliance on intentions.

Functional connectivity with medial temporal regions differs across cultures during post-encoding rest.

Connectivity of the brain at rest can reflect individual differences and impact behavioral outcomes, including memory. The present study investigated how culture influences functional connectivity with regions of the medial temporal lobe. In this study, 46 Americans and 59 East Asians completed a resting state scan after encoding pictures of objects. To investigate cross-cultural differences in resting state functional connectivity, left parahippocampal gyrus (anterior and posterior regions) and left hippocampus were selected as seed regions. These regions were selected, because they were previously implicated in a study of cultural differences during the successful encoding of detailed memories. Results revealed that left posterior parahippocampal gyrus had stronger connectivity with temporo-occipital regions for East Asians compared with Americans and stronger connectivity with parieto-occipital regions for Americans compared with East Asians. Left anterior parahippocampal gyrus had stronger connectivity with temporal regions for East Asians than Americans and stronger connectivity with frontal regions for Americans than East Asians. Although connectivity did not relate to memory performance, patterns did relate to cultural values. The degree of independent self-construal and subjective value of tradition were associated with functional connectivity involving left anterior parahippocampal gyrus. Findings are discussed in terms of potential cultural differences in memory consolidation or more general trait or state-based processes, such as holistic versus analytic processing.

Spatial frequency impacts perceptual and attentional ERP components across cultures.

Culture impacts visual perception in several ways.To identify stages of perceptual processing that differ between cultures, we usedelectroencephalography measures of perceptual and attentional responses to simple visual stimuli.Gabor patches of higher or lower spatialfrequencywere presented at high contrast to 25 American and 31 East Asian participants while they were watching for the onset of aninfrequent, oddball stimulus. Region of interest and mass univariate analyses assessed how cultural background and stimuli spatial frequency affected the visual evoked response potentials. Across both groups, the Gabor of lower spatial frequency produced stronger evoked response potentials in the anterior N1 and P3 than did the higher frequency Gabor. The mass univariate analyses also revealed effects of spatial frequency, including a frontal negativity around 150 ms and a widespread posterior positivity around 300 ms. The effects of spatial frequency generally differed little across cultures; although there was some evidence for cultural differences in the P3 response to different frequencies at the Pz electrode, this effect did not emerge in the mass univariate analyses. We discuss these results in relation to those from previous studies, and explore the potential advantages of mass univariate analyses for cultural neuroscience.

Aging, Empathy, and Prosocial Behaviors During the COVID-19 Pandemic.

OBJECTIVES: Previous literature suggests age-related increases in prosociality. Does such an age-prosociality relationship occur during the coronavirus disease 2019 (COVID-19) pandemic, or might the pandemic-as a stressor that may differently influence young and older adults-create a boundary condition on the relationship? If so, can empathy, a well-known prosocial disposition, explain the age-prosociality relationship? This study investigated these questions and whether the target (distant others compared to close others) of prosocial behaviors differs by age. METHODS: Participants completed a series of surveys on dispositional empathy and prosocial behaviors for a study assessing their experiences during the COVID-19 pandemic. There were 330 participants (aged 18-89) from the United States who completed all of the surveys included in the present analyses. RESULTS: Age was positively related to greater prosociality during the pandemic. Although empathy was positively associated with individuals' prosociality, it did not account for the age-prosociality association. Interestingly, increasing age was associated with greater prosocial behaviors toward close others (i.e., family, friends). DISCUSSION: Results are discussed in the context of socioemotional goals and substantiate that findings of age differences in prosocial behaviors occur during the period of limited resources and threat associated with the COVID-19 pandemic.

Effect of self-imagination on memory for older adults and aMCI patients.

Imagining an event from a personal perspective has been found to be able to enhance memory for words and sentences for healthy younger adults and brain-injured patients. However, little is known about how people with amnestic mild cognitive impairment (aMCI) respond to self-imagination, in comparison to healthy older adults. In the current study, participants were asked to process a group of objects using either a self-imagination approach or a baseline strategy in which the self was not heavily involved. Self-imagination shows a mnemonic advantage over the control strategy, though this pattern emerged more clearly for healthy older adults. Furthermore, suggestive evidence indicates that cognitive ability supports self-reference benefits for healthy older adults, but not aMCI patients. These findings extended previous research to reveal the effectiveness of self-imagination for older adults using pictorial stimuli and supported the viewpoint that aMCI could qualitatively change the way that cognitive resources are engaged.

Evaluating heart rate variability as a predictor of the influence of lying on memory.

Previous research suggests self-provided misinformation (lying) impairs memory for the truth, whereby more incorrect details are remembered compared to being truthful. The cognitive control processes evoked by inhibiting retrieval of truthful information may come at the expense of retaining that information in memory. Because lying requires quick adaptability to the situation, heart rate variability (HRV), reflecting cognitive control processes, is a useful metric of these cognitive demands. The present experiment extends previous research (Paige et al., 2019) and had participants complete a questionnaire orally in front of a panel while electrocardiography (ECG) data was collected. Participants were instructed to tell the truth for half of the questions and lie for the other half. For a subset of the questions, participants were instructed to elaborate on their response. After a delay, participants completed the same questionnaire on the computer, responding truthfully to all items. Results revealed that correct memory was lower for items participants previously lied about compared to truthful items. Although prior work suggests increased HRV is associated with increased cognitive control, HRV did not predict memory for truth or lie items. These findings are consistent with past literature showing that lying impairs memory for veridical information compared to truth-telling.

Culture-related differences in the neural processing of probability during mixed lottery value-based decision-making.

This study evaluated how differences in economic risk-taking in Westerners and East Asians reflect cultural differences in the analytic or holistic processing of probabilistic outcomes during value-based decisions. Twenty-seven Americans (US) and 51 Taiwanese (TW) young adults completed a functional magnetic resonance imaging (fMRI) Lottery Choice Task (LCT) experiment. Participants accepted or rejected stakes with varying probabilities of winning or losing different magnitudes of points. TW participants accepted more stakes when win probabilities were > 0.50, whereas US participants reduced their acceptance rates of winning stakes more discriminately as win probabilities decreased. Both groups rejected losing stakes (win probabilities < 0.50) with similar frequency. Critically, ventromedial prefrontal cortex (VMPFC) responses correspondingly showed greater discrimination between win probability conditions in US than TW groups. Our findings highlight a neurocognitive mechanism in the VMPFC for how cultural differences in distinguishing between probabilistic reward outcomes shape neural computations of risk and prospects.

STOP SHOUTING AT ME: The Influence of Case and Self-Referencing on Explicit and Implicit Memory.

Evidence suggests that physical changes in word appearance, such as those written in all capital letters, and the use of effective encoding strategies, such as self-referential processing, improves memory. In this study we examined the extent both physical changes in word appearance (case) and encoding strategies engaged at study influence memory as measured by both explicit and implicit memory measures. Participants studied words written in upper and lower case under three encoding conditions (self-reference, semantic control, case judgment), which was followed by an implicit (word stem completion) and then an explicit (item and context) memory test. There were two primary results. First, analyses indicated a case enhancement effect for item memory where words written in upper case were better remembered than lower case, but only when participants were prompted to attend to the case of the word. Importantly, this case enhancement effect came at a cost to context memory for words written in upper case. Second, self-referencing increased explicit memory performance relative to control, but there was no effect on implicit memory. Overall, results suggest an item-context memory trade-off for words written in upper case, highlighting a potential downside to writing in all capital letters, and further, that both physical changes to the appearance of words and differing encoding strategies have a strong influence on explicit, but not implicit memory.