A comparison of cervical rotation in age-matched adolescent competitive swimmers and healthy males.

Physical therapists routinely compare range of motion measurements with the opposite side and/or with a standard for "normal" range. However, "normal" range may vary in relation to the individual's occupational and recreational movement patterns. The purposes of this study were 1) to compare the range of active physiological cervical rotation in 14- to 17-year-old male competitive swimmers (N = 40) and controls (N = 40) and 2) to investigate the relationship between the freestyle stroke breathing pattern and differences in right and left cervical rotation in swimmers. Analysis of variance determined if a group difference existed in goniometric measurement of cervical rotation. The experimental group demonstrated a significantly greater mean range of total active cervical rotation right (p = 0.002) than the control group. Swimmers also demonstrated a significantly greater (p = 0.0002) range of rotation on their breathing side (mean difference of 5 degrees). It was concluded that the differences in physiological cervical rotation between swimmers and nonswimmers and between sides in the swimmers were influenced by the swimming activity. The clinician needs to consider the influence of activity when assessing range of motion.

Effects of cyclooxygenase and lipoxygenase inhibition on eicosanoids and healing of acetic acid colitis in rats.

Both cyclooxygenase products, such as prostaglandin (PG) E2, and lipoxygenase products, such as leukotriene (LT) B4, are increased in colitis and have potent proinflammatory actions. We studied effects of specific inhibitors of cyclooxygenase and 5-lipoxygenase on the healing of acetic acid colitis in rats. Acetic acid colitis was induced 24 hr before enzyme inhibition began. Four days after induction of colitis, the area of gross colonic mucosal damage was determined by image analysis. Eicosanoid content in the intestinal lumen was quantitated by radioimmunoassay following chromatographic purification. Under these conditions, indomethacin significantly retarded the healing of colonic lesions and inhibited PGE2 by > 90% compared to placebo-treated colitis rats. AA861 had no effect on the healing of lesions, although > 75% inhibition of leukotriene synthesis was demonstrated. These results suggest that inhibition of endogenous colonic prostaglandins can impair healing mechanisms in acute colitis even after inflammation has developed. In contrast, inhibition of leukotriene synthesis did not affect healing.

Morphogenesis of ascospores in Saccharomyces cerevisiae.

Ultrastructural changes associated with ascospore formation in Saccharomyces cerevisiae were investigated by using freeze-etching and thin-sectioning techniques. The first nuclear division (meiosis I) is indicated by the appearance of spindle fibers within the nucleus. The nucleus subsequently elongates and eventually assumes a barbell shape; the second nuclear division (meiosis II) occurs before nuclear separation. The spindle fibers involved in meiosis II appear to be oriented perpendicular to those observed in meiosis I. A discrete bilaminar structure (forespore wall) progressively delineates each ascospore nucleus and encloses cytoplasmic material including mitochondria and endoplasmic reticulum. The forespores then elongate, close off, and become separated from the ascus cytoplasm by membranes. The ascospores assume a spherical shape as spore coat material is laid down; the latter stages of ascospore formation are characterized by thickening of the ascospore wall and disintegration of the ascus cytoplasm. No structures which could be identified as chromosomes were observed.