[Risk of glucose metabolism changes in spouses of Mexican patients with type 2 diabetes]. / Riesgo de alteración en el metabolismo de la glucosa en cónyuges de pacientes mexicanos con diabetes mellitus tipo 2.

BACKGROUND AND OBJECTIVE: To determine whether in the Mexican population the spouses of patients with type 2 diabetes mellitus (DM2) have an increased risk of any degree of glucose intolerance compared with spouses of subjects without diabetes. SUBJECTS AND METHOD: An analytical cross-sectional study was made in the Family Medicine Unit number 62 of the Mexican Institute of Social Security, located in the State of México. A random sample of 87 spouses of patients with DM2 (group ED) was compared with 87 spouses of subjects with a normal glucose tolerance (group ENOD). Risk factors for DM2 were investigated; spouses in both groups underwent oral glucose tolerance test, and total cholesterol, triglycerides, blood pressure, body mass index and waist circumference were measured. The frequency of impaired fasting glucose, impaired glucose tolerance and DM2 were compared in both groups and the odds ratio was calculated. RESULTS: In the group ED there were 38 (43.7%) subjects with any degree of glucose intolerance vs. 23 (26.4%) in the ENOD group -odds ratio = 2.16 (95% confidence interval, 1.14-4.08) in the bivariate analysis, and odds ratio = 2.37 (95% confidence interval, 1.14-4.91) in the logistic regression-. In the group ED a higher systolic blood pressure was observed (P=.02). There were no significant differences in age, sex, body mass index, waist circumference, total cholesterol, triglycerides and diastolic blood pressure. The frequency of risk factors for diabetes was similar in both groups. CONCLUSIONS: In the Mexican population, the spouses of subjects with DM2 have a higher risk of any alteration in the glucose tolerance than spouses of subjects with a normal glucose metabolism.

Riesgo de alteración en el metabolismo de la glucosa en cónyuges de pacientes mexicanos con diabetes mellitus tipo 2 / Risk of disorders in the glucose metabolism in spouses of Mexican patients with type 2 diabetes

FUNDAMENTO Y OBJETIVO: Determinar si en la población mexicana los cónyuges de pacientes condiabetes mellitus tipo 2 (DM2) tienen mayor riesgo de alteración en el metabolismo de la glucosa(AMG) que los cónyuges de personas sin diabetes.SUJETOS Y MÉTODO: Se ha realizado un estudio transversal analítico en la Unidad de Medicina Familiarnúmero 62 del Instituto Mexicano del Seguro Social, ubicada en el Estado de México. Secomparó una muestra aleatoria de 87 esposos de pacientes con DM2 (grupo ED), con 87 espososde personas con metabolismo normal de la glucosa (grupo ENOD). En ambos grupos se investigaronlos factores de riesgo para diabetes, se realizó una curva de tolerancia a la glucosaoral y se midieron el colesterol total, triglicéridos, presión arterial, índice de masa corporal ycircunferencia de la cintura. Se comparó la frecuencia de AMG (alteración de la glucosa enayunas, intolerancia a la glucosa y diabetes mellitus) y se calculó la odds ratio.RESULTADOS: En el grupo ED hubo 38 personas (43,7%) con alguna AMG, frente a 23 (26,4%)en el grupo ENOD, con una odds ratio de 2,16 (intervalo de confianza del 95%, 1,14-4,08) enel análisis bivariado y de 2,37 (intervalo de confianza del 95%, 1,14-4,91) en la regresión logística.En el grupo ED se observó una mayor presión arterial sistólica (p = 0,02). No hubo diferenciassignificativas en cuanto a la edad, sexo, índice de masa corporal, circunferencia de lacintura, colesterol total, triglicéridos y presión arterial diastólica. La frecuencia de factores deriesgo para diabetes fue similar en ambos grupos.CONCLUSIONES: En población mexicana, los cónyuges de pacientes con DM2 tienen mayor riesgode AMG que los cónyuges de personas con metabolismo normal de la glucosa

BACKGROUND AND OBJECTIVE: To determine whether in the Mexican population the spouses of patientswith type 2 diabetes mellitus (DM2) have an increased risk of any degree of glucose intolerancecompared with spouses of subjects without diabetes.SUBJECTS AND METHOD: An analytical cross-sectional study was made in the Family Medicine Unitnumber 62 of the Mexican Institute of Social Security, located in the State of México. A randomsample of 87 spouses of patients with DM2 (group ED) was compared with 87 spouses ofsubjects with a normal glucose tolerance (group ENOD). Risk factors for DM2 were investigated;spouses in both groups underwent oral glucose tolerance test, and total cholesterol, triglycerides,blood pressure, body mass index and waist circumference were measured. The frequencyof impaired fasting glucose, impaired glucose tolerance and DM2 were compared inboth groups and the odds ratio was calculated.RESULTS: In the group ED there were 38 (43.7%) subjects with any degree of glucose intolerancevs. 23 (26.4%) in the ENOD group –odds ratio = 2.16 (95% confidence interval, 1.14-4.08) in the bivariate analisys, and odds ratio = 2.37 (95% confidence interval, 1.14-4.91) inthe logistic regression–. In the group ED a higher systolic blood pressure was observed(P=.02). There were no significant differences in age, sex, body mass index, waist circumference,total cholesterol, triglycerides and diastolic blood pressure. The frequency of risk factors fordiabetes was similar in both groups.CONCLUSIONS: In the Mexican population, the spouses of subjects with DM2 have a higher risk ofany alteration in the glucose tolerance than spouses of subjects with a normal glucose metabolism

Mononucleosis infecciosa / Infections mononucleosis

Mononucleosis infecciosa es un padecimiento infectocontagioso causado por un virus de la familia Herpes viridae llamado virus de Epstein Barr. Sus manifestaciones en la niñez son mínimas, pudiendo presentarse como un cuadro catarral. En el adolescente y el adulto joven sus manifestaciones clínicas son características, presentando datos de afección de tejido linfoide y del sistema reticuloendotelial. Es en este último grupo de edad donde se presentan cuadros y complicaciones graves. El diagnóstico se establece con base en los criterios de Hoagland y mediante la identificación de sus diversos antígenos, así como anticuerpos dirigido contra ellos. Se ha relacionado a la mononucleosis infecciosa con el desarrollo de tumores del tejido linfoide, así como al carcinoma rinofaríngeo. No existe, a la fecha, tratamiento especial para este padecimiento viral