ABSTRACT
OBJECTIVE: The increase in the consumption of anti-ulcer drugs is accompanied by a high rate of incorrect use. The objectives of this study were to analyse the adequacy of repeat prescriptions of proton pump inhibitors (PPIs) in a Medical Centre, and to evaluate the efficacy of an improvement intervention. MATERIAL AND METHOD: A cross-sectional, descriptive and observational study of prevalence was conducted on patients in a medical centre under treatment with PPIs for at least 3consecutive months (November 2016-January 2017). An analysis was performed that included the indication, dosage and time of treatment with PPIs, drug interactions, and possible risks that could be related with their use. An intervention was carried out to optimise rational and efficient prescribing of these medicines. RESULTS: A total of 703 patients were included in the study, which is 5.4% of the total adult patients that are assigned to the centre. Adequacy criteria were not met by 436 (62.0%). Of these, 52.5% were women, 70.0% were over 65 years old, and had been on treatment for a mean of 2.7 ± 1.9 years. Interactions were observed in 48.1%, and 29.0% had some risk factors. After the intervention, the inadequate prescribing was corrected in 112 (25.7%) patients, which was a reduction of 46.1% (P<.001). CONCLUSIONS: There is a high prevalence of prescription and inadequacy of PPIs in the long term. This suggests that it is necessary to improve training of professionals to strengthen rational use and to reduce risks. The launch of an intervention programme has led to the revision and optimisation of treatments.
Subject(s)
Inappropriate Prescribing/statistics & numerical data , Practice Patterns, Physicians'/statistics & numerical data , Primary Health Care , Proton Pump Inhibitors/administration & dosage , Aged , Aged, 80 and over , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Practice Patterns, Physicians'/standards , PrevalenceABSTRACT
No disponible
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Humans , Nanotechnology/trends , Nanostructures , Nanoparticles , Biomedical Engineering/trends , Biomedical Technology/trends , Biomedical Research/trendsABSTRACT
No disponible
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Humans , Neoplasms/therapy , Nanoparticles/therapeutic use , Cell- and Tissue-Based Therapy/methods , Drug Implants/therapeutic use , Chemotherapy, Cancer, Regional Perfusion/methodsABSTRACT
No disponible
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Middle Aged , Pregnancy , Adult , Female , Humans , Pregnancy Complications, Hematologic , Pregnancy Complications, Cardiovascular , Survival Rate , Anti-HIV Agents , Retrospective Studies , Acquired Immunodeficiency Syndrome , Hospitalization , Factor VII Deficiency , Severity of Illness Index , Brain IschemiaSubject(s)
Anti-Infective Agents/therapeutic use , Bacteremia/drug therapy , Cross Infection/drug therapy , Hematologic Neoplasms/complications , Neutropenia/drug therapy , Administration, Oral , Adult , Bacteremia/microbiology , Catheterization/adverse effects , Cross Infection/microbiology , Drug Evaluation , Female , Fluoroquinolones , Humans , Male , Neutropenia/microbiologyABSTRACT
No disponible
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Humans , Home Care Services, Hospital-Based , Risk Factors , Neutropenia , Antineoplastic Agents , Fever , NeoplasmsABSTRACT
No disponible
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Humans , Arthroplasty, Replacement, Knee , Arthroplasty, Replacement, Hip , Postoperative Complications , Anticoagulants , Heparin, Low-Molecular-WeightABSTRACT
No disponible
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Humans , Antibodies, Antiphospholipid , Myocardial Ischemia , Thrombophilia , Blood Cells , HemostasisABSTRACT
No disponible
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Adult , Male , Humans , Sacrum , Brucellosis , Ilium , Agricultural Workers' Diseases , Thrombocytopenia , Fatal Outcome , Osteitis , Cerebral Hemorrhage , AbscessABSTRACT
No disponible
Subject(s)
Humans , Partial Thromboplastin Time , ABO Blood-Group System , Thrombin/biosynthesis , Thromboplastin , von Willebrand FactorSubject(s)
Factor VII Deficiency/metabolism , Monocytes/metabolism , Thrombosis/etiology , Thrombosis/metabolism , Child , Factor VII Deficiency/complications , Factor VII Deficiency/diagnosis , Female , Hemophilia A/complications , Hemophilia A/diagnosis , Humans , Male , Middle Aged , Myocardial Infarction/complications , Myocardial Infarction/diagnosis , Thrombosis/complicationsSubject(s)
Arthroplasty, Replacement, Hip , Arthroplasty, Replacement, Knee , Blood Coagulation Disorders/etiology , Surgical Wound Infection/etiology , Transfusion Reaction , Transplantation Immunology , Aged , Blood Coagulation Disorders/immunology , Female , Humans , Male , Middle Aged , Surgical Wound Infection/immunology , Transplantation, HomologousABSTRACT
No disponible
