ABSTRACT
BACKGROUND: Identifying persons at high risk for advanced colorectal neoplasia can aid in the prevention of colon cancer. Previous studies have shown that some patients can present with proximal advanced neoplasia with no distal findings. AIMS: To determine the factors related to advanced neoplasia and advanced proximal colorectal neoplasia in a Latin American population. MATERIAL AND METHODS: A prospective, cross-sectional, observational, analytic study was conducted. It included patients that underwent colonoscopy at the Policlínico Peruano Japonés within the time frame of January and July 2012. Advanced neoplasia was defined as the presence of lesions ≥ 10mm with a villous component, high-grade dysplasia, or carcinoma. The splenic flexure was the limit between the proximal and distal colon. RESULTS: A total of 846 patients were included in the study. Advanced neoplasia was detected in 108 patients (12.8%) and advanced proximal neoplasia in 55 patients (6.7%), 42 (76.4%) of whom had no neoplasia in the distal colon. Factors related to advanced neoplasia found in the multivariate analysis were age, at the intervals of 50-59 (p=0.019), 60-69 (p=0.016), and ≥ 70 years (0.002) and male sex (p=0.003). In the evaluation of advanced proximal neoplasia, the multivariate analysis identified the 60-69 year age interval (p=0.039) and advanced distal neoplasia (p=0.028) as factors related to advanced proximal disease. The ROC curve established the age cut-off point at 60 years for initially performing colonoscopy, rather than sigmoidoscopy. CONCLUSIONS: Age and sex are related to advanced neoplasia, whereas age and advanced distal neoplasia are related to advanced proximal neoplasia.
Subject(s)
Adenoma/pathology , Colon/pathology , Colorectal Neoplasms/pathology , Adenoma/diagnostic imaging , Adenoma/etiology , Adult , Age Factors , Aged , Aged, 80 and over , Colonoscopy , Colorectal Neoplasms/diagnostic imaging , Colorectal Neoplasms/etiology , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Multivariate Analysis , Neoplasm Staging , Peru , Prospective Studies , Risk Factors , Sex FactorsABSTRACT
La persistencia del conducto onfalomesentérico ha sido reportada en diversas publicaciones pediátricas ya sea a través de la aparición de un divertículo de Meckel que es la forma más común, o ya sea por la aparición de segmentos con permeabilidad parcial o total el mismo. Se han presentado casos esporádicos donde esta anomalía ha originado episodios de obstrucción intestinal en lactantes y niños, especialmente bajo la forma de unabanda fibrosa remanente. La presentación en el adulto, sin embargo, es extremadamente infrecuente. El caso presentado en este reporte muestra hallazgos compatibles con un conducto onfalomesentérico con permeabilidad parcial, que originó un cuadro de obstrucción intestinal en un adulto joven.
The persistence of the onphalomesenteric duct has been reported in several pediatricpublications either through the appearance of Meckel diverticulum that are commonest, orby the appearance of segments with partial or total permeability of itself. Sporadic caseshave appeared where this anomaly has originated episodes of intestinal obstruction ininfants and children specially under the form of a fibrous band. However, adult presentationis extremely infrecuent. The case presented in this report shows compatible findings witha onphalomesenteric conduit with partial permeability, that I originate an intestinal pictureof obstruction in a young adult.
