ABSTRACT
Isolated ACTH deficiency (IAD) is a rare entity characterized by secondary adrenal insufficiency with low levels of serum cortisol, decreased production of ACTH, adequate secretion of other pituitary hormones and normal pituitary structure on radioimaging. The prevalence of IAD as a cause of secondary adrenal insufficiency has not been determined. Impairment of growth hormone (GH) secretion has been noted in 20 to 30% of patients with IAD which is normalized after glucocorticoid replacement. We report the case of a 50 years-old female with symptoms and laboratory results suggestive of adrenal insufficiency. Insulin tolerance test confirmed ACTH and growth hormone deficiency. The rest of the anterior pituitary hormones were normal. A pituitary MRI was unremarkable. Glucocorticoid replacement therapy started and eight months afterwards glucagon stimulation test revealed persistent ACTH deficiency but nor- mal growth hormone secretion. IAD can present with nonspecific symptoms and could be potentially fatal in an acute stressful period. Prompt recognition is essential to decrease morbidity and mortality.
Subject(s)
Adrenocorticotropic Hormone/deficiency , Endocrine System Diseases/complications , Genetic Diseases, Inborn/complications , Glucocorticoids/administration & dosage , Human Growth Hormone/deficiency , Hypoglycemia/complications , Insulin Resistance , Endocrine System Diseases/diagnosis , Female , Genetic Diseases, Inborn/diagnosis , Hormone Replacement Therapy/methods , Humans , Hypoglycemia/diagnosis , Middle AgedABSTRACT
A 54-year-old man was seen in our endocrinology clinic with evidence of a limited range of motion in his left foot. He had a history of diabetes mellitus type 2 and atrial fibrillation. His family history included evidence of skeletal deformities in some of his relatives. This could imply the potential existence of a hereditary condition. It is worth noting that spontaneous mutations have been reported in some cases. A pertinent physical examination revealed a surgical scar on the patient's left knee, a hallux valgus deformity on his left foot with compromised joint function, and painless bony prominences on that same foot. The skeletal survey findings were consistent with multiple hereditary exostoses. Multiple osteochondromatosis (MO) is a rare genetic disorder associated with serious complications that may significantly affect the health related quality of life of anyone having the disorder. To prevent further complications, these patients require long-term follow-up with regular clinical and radiological examinations.
Subject(s)
Exostoses, Multiple Hereditary/diagnosis , Quality of Life , Exostoses, Multiple Hereditary/complications , Exostoses, Multiple Hereditary/pathology , Humans , Male , Middle AgedABSTRACT
A 54-year-old woman came to our endocrinology clinics presenting with upper and lower extremity paresthesia, salt cravings, episodes of hypotension, fatigue and a long term history of depression. Physical exam was unremarkable. Cervical and brain MRI ordered by her neurologist three years ago revealed sella and pituitary normal in size, stable very small 3 mm pituitary incidentaloma and mild disc bulging. Basal pituitary hormonal screening showed low cortisol and ACTH levels. Insulin Tolerance Test and Glucagon Stimulation Test confirmed secondary ACTH deficiency with concomitant GH deficiency. In spite of medical counseling the patient refused glucocorticoid replacement. Due to the non-specific symptoms of this condition it remains a challenge to be diagnosed by clinicians. In conclusion: Our case shows that hormonal deficiencies may occur in small tumors less than 6 mm.
Subject(s)
Adenoma/metabolism , Adrenocorticotropic Hormone/deficiency , Human Growth Hormone/deficiency , Hydrocortisone/deficiency , Hypopituitarism/diagnosis , Pituitary Neoplasms/metabolism , Adenoma/pathology , Adrenocorticotropic Hormone/metabolism , Female , Glucagon , Human Growth Hormone/metabolism , Humans , Hydrocortisone/metabolism , Hypopituitarism/etiology , Hypopituitarism/physiopathology , Incidental Findings , Magnetic Resonance Imaging , Middle Aged , Pituitary Neoplasms/pathology , Pituitary-Adrenal System/physiopathology , Symptom Assessment , Treatment Refusal , Tumor BurdenABSTRACT
Mucormycosis is an uncommon but fatal fungal infection of airborne transmission. Its is usually seen in immunocompromised patients including diabetics, malignancies, transplant patients and renal insufficiency. We review the case of an immunocompromised patient unresponsive to broad-spectrum antibiotics and conventional antifungal therapy with lung mucormycosis.
Subject(s)
Immunocompromised Host , Lung Diseases, Fungal , Mucormycosis , Aged, 80 and over , Fatal Outcome , Humans , Lung Diseases, Fungal/diagnosis , Lung Diseases, Fungal/therapy , Male , Mucormycosis/diagnosis , Mucormycosis/therapyABSTRACT
Choledochal cyst type II, is an extremely rare cause of portal hypertension, severe pancytopenia in an adult patient, and a complication of long-standing disease. We present an uncommon cause of portal hypertension in a young female patient secondary to an obstructive choledochal cyst type II provoking massive splenomegaly and severe pancytopenia. A high level of clinical suspicion is important due to its high mortality rate if it remains undiagnosed. To our knowledge there are few publications describing this rare type of choledochal cyst in a Hispanic adult.
