Evolución a largo plazo de la calidad de vida en pacientes con artritis reumatoide tratados con terapias biológicas / Long-term changes in the quality of life of patients with rheumatoid arthritis treated with biological therapies

Objetivo: Analizar la evolución a largo plazo de la calidad de vida relacionada con la salud (CVRS) en pacientes con artritis reumatoide (AR) tratados con terapias biológicas. Método: Estudio observacional prospectivo realizado entre octubre de 2006 y mayo de 2011. Se seleccionó a pacientes mayores de edad, diagnosticados de AR, tratados durante al menos un año con anti-TNF (infliximab o etanercept) y que no hubieran recibido otros tratamientos biológicos previos. Completaron el estudio 41 pacientes, cumplimentando el cuestionario específico validado QOL-AR en 3ocasiones: E1 (entre septiembre de 2006 y febrero de 2007), E2 (entre abril de 2008 y enero de 2009) y E3 (entre julio de 2010 y mayo de 2011). Los datos se analizaron con Epi-Info versión 3.3-2004 para Windows (R) y Excel 2007; la comparación de las medias con la prueba t de Student y la relación entre valores de un mismo paciente, mediante regresión lineal. Resultados: Resultados globales: tendencia descendente no estadísticamente significativa: 7,09±1,15 en E1; 6,90±1,60 en E2 y 6,52±1,59 en E3. Los ítems con mayor puntuación fueron los relacionados con aspectos psicosociales (ayuda familiar, interacción con familia y amigos). La dimensión física fue la peor valorada (habilidad física, dolor artrítico, artritis). Entre E2 y E3 aumentó significativamente la valoración de la ayuda familiar (p=0,0008) y disminuyeron significativamente tensión nerviosa (p=0,0119) y estado de ánimo (p=0,0451). Conclusiones: La CVRS de los pacientes es buena y se ha mantenido prácticamente invariable tras unos 6años de estudio. Es probable que parte de la estabilidad en la CVRS sea atribuible al tratamiento

Objective: To analyze the changes in health-related quality of life (HRQoL) of patients with rheumatoid arthritis (RA) treated with biological therapies. Method: Observational prospective study performed from October 2006 to May 2011. The inclusion criteria were adult patients, diagnosed with RA, treated for at least one year with anti-tumor necrosis factor therapy (infliximab or etanercept), who had not received other biological treatments previously. A total of 41 patients who completed the study undertook the specific and validated questionnaire QoL-RA Scale 3 times: E1 (September 2006-February 2007), E2 (April 2008-January 2009) and E3 (July 2010- May 2011). Data analysis was conducted using Epi-Info version 3.3 2004 for Windows(R) and Excel 2007; mean comparisons were evaluated by Student's t-test and the relationship between the 3 outcomes for each patient by lineal regression. Results: Overall results show a downward trend which was not statistically significant: 7.09 (standard deviation [SD]=1.15) in E1; 6.90 (SD=1.60) in E2; and 6.52 (SD=1.59) in E3. Items with higher scores were those related to psychosocial aspects (help from family, interaction with family and friends), whereas the physical dimension was valued more poorly (physical ability, arthritis pain, arthritis). Between E2 and E3 there was a significant increase in help from family (P=.0008), whereas level of tension (P=.0119) and mood (P=.0451) decreased significantly. Conclusions: In all, HRQoL reported by patients is good and has remained unchanged after approximately 6 years of study. The stability of HRQoL is probably partly attributable to treatment

Long-term changes in the quality of life of patients with rheumatoid arthritis treated with biological therapies. / Evolución a largo plazo de la calidad de vida en pacientes con artritis reumatoide tratados con terapias biológicas.

OBJECTIVE: To analyze the changes in health-related quality of life (HRQoL) of patients with rheumatoid arthritis (RA) treated with biological therapies. METHOD: Observational prospective study performed from October 2006 to May 2011. The inclusion criteria were adult patients, diagnosed with RA, treated for at least one year with anti-tumor necrosis factor therapy (infliximab or etanercept), who had not received other biological treatments previously. A total of 41 patients who completed the study undertook the specific and validated questionnaire QoL-RA Scale 3 times: E1 (September 2006-February 2007), E2 (April 2008-January 2009) and E3 (July 2010- May 2011). Data analysis was conducted using Epi-Info version 3.3 2004 for Windows® and Excel 2007; mean comparisons were evaluated by Student's t-test and the relationship between the 3 outcomes for each patient by lineal regression. RESULTS: Overall results show a downward trend which was not statistically significant: 7.09 (standard deviation [SD]=1.15) in E1; 6.90 (SD=1.60) in E2; and 6.52 (SD=1.59) in E3. Items with higher scores were those related to psychosocial aspects (help from family, interaction with family and friends), whereas the physical dimension was valued more poorly (physical ability, arthritis pain, arthritis). Between E2 and E3 there was a significant increase in help from family (P=.0008), whereas level of tension (P=.0119) and mood (P=.0451) decreased significantly. CONCLUSIONS: In all, HRQoL reported by patients is good and has remained unchanged after approximately 6 years of study. The stability of HRQoL is probably partly attributable to treatment.

Reactivación de tuberculosis pulmonar durante el tratamiento con triple terapia de la hepatitis C / Reactivation of pulmonary tuberculosis during treatment with triple therapy for hepatitis C

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Una estrategia poco utilizada en el cuidado de pacientes con Enfermedad Renal Crónica: la educación en grupo y multidisciplinar de pacientes y sus familiares / A little-used strategy in caring for patients with chronic kidney disease: multidisciplinary education of patients and their relatives

Los equipos multidisciplinares, son una estrategia sugerida hace ya más de un decenio por grupos canadienses. Los pacientes tratados en un ámbito multidisciplinar demuestran un mejor conocimiento de la enfermedad renal crónica y mejores parámetros bioquímicos. Los objetivos fueron, aumentar los conocimientos, en nuestros pacientes con enfermedad renal crónica avanzada y su familia, sobre su enfermedad, su correcto cuidado y sobre el tratamiento renal sustitutivo, a través de la educación en grupo. Valorar si la información aumenta el nivel de ansiedad de los pacientes. Valorar el grado de satisfacción con la intervención educación en grupo. Estudio retrospectivo que contó con 19 pacientes, asistentes a los dos cursos. Se realizaron dos cuestionarios al inicio y al final del curso sobre nivel de conocimientos y el nivel de ansiedad (Inventario de Ansiedad Estado-Rasgo). Al final de cada edición, se realizó un cuestionario de evaluación. Las variables estudiadas fueron el sexo, edad, nivel de estudios y asistencia de un familiar. El nivel de conocimientos alcanzó una diferencia estadísticamente significativa entre ambos cuestionarios (inicial-final) (p = 0,013). Los resultados obtenidos en la evaluación del nivel de ansiedad mostraron un ligero incremento en la ansiedad. El cuestionario de satisfacción mostró una valoración muy positiva de la intervención. Podemos concluir, que la mayoría de los pacientes han aumentado sus conocimientos sobre enfermedad renal crónica avanzada y técnicas de sustitución, han demostrado una alta satisfacción con la experiencia de esta intervención y la mayoría han experimentado un ligero aumento de ansiedad (AU)

Multidisciplinary teams are a strategy that was suggested more than ten years ago by Canadian groups. Patients treated in an multidisciplinary environment show better knowledge of CKD and better biochemical parameters. The goals were to increase knowledge in our patients with ACKD and their family about their illness, correct care and renal replacement therapy, through group education, to evaluate whether the information increased the patients’ level of anxiety and to evaluate the degree of satisfaction with the group education. This is a retrospective study carried out with 19 patients, who attended both courses. Two questionnaires were completed at the start and end of the course on the level of knowledge and level of anxiety (State-Trait Anxiety Inventory STAI). At the end of each course, an assessment questionnaire was completed. The variables studied were sex, age, level of education and presence of a relative. The level of knowledge reached a statistically significant difference between the two questionnaires (start-end) (p = 0.013). T he results obtained in the evaluation of the level of anxiety showed a slight increase in anxiety. The satisfaction questionnaire showed a very positive evaluation of the action. We can conclude that most of the patients have increased their knowledge of ACKD and replacement techniques, have shown a high degree of satisfaction with the experience of this intervention and most have experienced a slight increase in anxiety (AU)