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Rev. bras. neurol ; 45(2): 35-38, abr.-jun. 2009. ilus
Article in Portuguese | LILACS | ID: lil-518013

ABSTRACT

O angioedema é uma reação inflamatória local potencialmente grave. Estudos evidenciam uma incidência destes casos após uso de alteplase entre 0,02% e 5,1%. Relatamos um caso de acidente vascular cerebral isquêmico agudo tratado com alteplase que evoluiu com angioedema e piora clínica. Este paciente teve expressiva melhora neurológica com posterior declínio clínico após o angioedema. O mecanismo inflamatório neste caso pode ter desempenhado papel determinante na reoclusão.


Angioedema is a potentially severe local inflammatory reaction. There is an incidence of 0.02% to 5.1% in patients treated with alteplase. We report a case of acute ischemic stroke that was treated with alteplase and presented a life threatening allergic reaction. This patient had an important neurologic improvement in the beginning, but this benefit was lost after angioedema. The inflammatory mechanism that causes angioedema is sometimes decisive in re-occlusion.


Subject(s)
Humans , Male , Middle Aged , Thrombolytic Therapy , Tissue Plasminogen Activator/therapeutic use , Stroke/drug therapy , Angioedema , Brazil , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Tissue Plasminogen Activator/administration & dosage , Myocardial Infarction
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