ABSTRACT
PURPOSE: With uveitis being one of the leading causes of blindness worldwide, biological therapies have arisen as an option for the treatment of refractory cases based on good results shown in clinical practice. The goal of this study is to provide a systematic review of current knowledge of the role and possible uses of tocilizumab in the field of ophthalmology. MATERIALS AND METHODS: We performed a search for records reporting the use of tocilizumab for various diseases in MEDLINE (PubMed and OVID). We conducted an analysis of several individual studies and their reported individual patient data (82 eyes of 45 patients) published from 2011 to 2017. CONCLUSIONS: Tocilizumab may prove to be an effective choice for the treatment of a variety of ocular conditions such as refractory uveitis, inflammatory macular edema, vitreo-retinal tumors and thyroid orbitopathy, leading to control of the inflammation in these patients. Further studies need to be conducted to establish its safety and efficacy.
Subject(s)
Antibodies, Monoclonal, Humanized/therapeutic use , Eye Diseases/drug therapy , Inflammation/drug therapy , Orbital Diseases/drug therapy , Humans , Treatment Outcome , Visual AcuityABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Optic Neuropathy, Ischemic/complications , Hemochromatosis/complications , Vision Disorders/etiology , Risk Factors , Iron Overload/complicationsSubject(s)
Iris/injuries , Phacoemulsification , Aged , Cataract Extraction , Humans , Hyphema/etiology , Male , Wounds, Nonpenetrating/complicationsABSTRACT
La coroides es la capa media del ojo, un tejido muy vascularizado y pigmentado, cuyo papel ya ha sido probado en numerosas enfermedades oftálmicas. Pero no ha sido hasta los últimos años cuando hemos sido capaces de cuantificar y medir de una forma fiable, precisa y reproducible su grosor y su forma. Las técnicas de imagen basadas en ultrasonidos y la angiografía con verde de indocianina fueron las primeras en ser utilizadas para el estudio de la coroides, y aún mantienen su uso y sus indicaciones clínicas para el diagnóstico y manejo de algunas enfermedades oculares. Pero fue la llegada de la tomografía de coherencia óptica la que supuso el mayor avance en cuanto a la visualización de la coroides se refiere. En esta revisión se discutirán modalidades de imagen coroidea pasadas, presentes y futuras, con una especial atención sobre la tomografía de coherencia óptica y su más reciente desarrollo
The choroid is the middle layer of the eye, a very vascular and pigmented tissue, with its role in several ophthalmological pathologies already having been clearly established. But it was not until the last few years that we have been able to reliably and precisely measure and quantify its shape and thickness. Ultrasound technology and indocyanine green angiography were the first techniques used for the study of the choroid, and they still maintain their use and clinical indications for the diagnosis and management of several pathologies. But it was the advent of optical coherence tomography that was the greatest breakthrough in choroidal imaging. In this chapter, the past, current and future image modalities for the study of the choroid will be discussed, with special focus on optical coherence tomography and its latest developments
Subject(s)
Humans , Male , Female , Choroid Diseases/epidemiology , Choroid Diseases , Choroid , Tomography, Optical Coherence/instrumentation , Tomography, Optical Coherence/methods , Tomography, Optical Coherence , Diagnostic Imaging/trends , Angiography/instrumentation , Angiography/methodsSubject(s)
Hemochromatosis/complications , Optic Neuropathy, Ischemic/etiology , Aged , Humans , Male , Visual AcuityABSTRACT
The choroid is the middle layer of the eye, a very vascular and pigmented tissue, with its role in several ophthalmological pathologies already having been clearly established. But it was not until the last few years that we have been able to reliably and precisely measure and quantify its shape and thickness. Ultrasound technology and indocyanine green angiography were the first techniques used for the study of the choroid, and they still maintain their use and clinical indications for the diagnosis and management of several pathologies. But it was the advent of optical coherence tomography that was the greatest breakthrough in choroidal imaging. In this chapter, the past, current and future image modalities for the study of the choroid will be discussed, with special focus on optical coherence tomography and its latest developments.
