[Characteristics of oxidative stress in mental maladaptation].

Changes in the balance of pro and antioxidant systems were studied in persons in state of mental maladaptation, developed under the influence of emotional stress. Activation of lipid peroxidation has been revealed associated with increase of amount of malondialdehyde in erythrocytes and blood serum in persons surveyed. Activity of catalase and glutathione peroxidase in erythrocytes in persons in state of mental stress was increased and glutathione preductase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase has been reliably reduced as compared with group of healthy people. Comparative chemiluminiscent analysis of common antioxidant properties of serum of blood of studied groups has also revealed decrease of antioxidant properties of blood under influence of mental stress.

[Genetic epidemiology of schizophrenia in the population of Tomsk Oblast. Dependence of parameters of the occurrence of schizophrenia among relatives on the method of proband sample formation]. / Geneticheskaia épidemiologiia shizofrenii v populiatsii Tomskoi oblasti. Zavisimost' pokazatelei rasprostranennosti shizofrenii sredi rodstvennikov ot sposoba formirovaniia vyborki probandov.

The program of genetic-epidemiological study of schizophrenia in five districts of the Tomsk region is presented. According to standardized methods, 610 diagnosed patients (epidemiological register) were examined, 74.1% of them being at random registered as probands (452 families of the epidemiological sample). 229 probands of non-epidemiological sample were registered in psychiatric hospitals. Schizophrenia occurrence parameters among first-degree relatives of probands of the non-epidemiological sample were regularly overestimated, as compared to the epidemiological sample. The methodical sources of contradictions in clinico-genealogical studies are discussed; the conclusion about representativeness+ of the probands' epidemiological sample is made.