[The characteristics of treating hypertension with clofelin in pregnant women]. / Osobennosti lecheniia gipertonicheskoi bolezni klofelinom u beremennykh.

Long-term effective use of clophelin was observed only in 1/3 of pregnant suffering of hypertensive disease. The efficacy of treatment with this drug is determined not so much by its hypotensive action as by its influence on the state of the central hemodynamics. Clophelin may often reduce the minute cardiac volume and thus, deteriorate the uterine-placental blood flow and that is why its use be carried out under meticulous control of the central circulation. The authors designed a mathematical model for the prognosis of the efficiency of long-term clophelin treatment in pregnant women with hypertensive disease.

[The role of prostaglandins in the development of associated late pregnancy toxicosis in hypertension patients]. / Rol' prostaglandinov v razvitii sochetannogo pozdnego toksikoza beremennykh u bol'nykh gipertonicheskoi bolezn'iu.

The plasma levels of prostaglandins A, E, and F2 alpha were measured by the radioimmunoassay in 146 hypertensive and 62 healthy pregnant females. It was ascertained that beginning in the second trimester, the ratio of various prostaglandins is impaired in the direction of increasing values of substances from the pressor group as the hypertensive disease evolves. This is due to lower levels of prostaglandins A and E and/or higher levels of prostaglandins F2 alpha. In associated late gestosis, prostaglandin levels are related to the clinical manifestations of this disease. There are increased prostaglandin F2 alpha concentrations with severe nephropathy. The studies indicate that prostaglandins affect the course of hypertensive disease in pregnant women and the development of associated late gestosis.

[Prevention of fetal and neonatal developmental disorders in diabetes mellitus]. / Profilaktika narushenii razvitiia ploda i novorozhdennogo pri sakharnom diabete.

The experience of follow-up and treatment of over 500 pregnant diabetic women and their newborns is summarised. The incidence of severe complications of pregnancy and labour is shown to rise significantly in this condition, the fetal development and neonatal status being impaired. The effects of the genetic factors, hypoxia, ketoacidosis, metabolic and hormonal errors, complicated pregnancy and labour on the perinatal disease development are defined. A comparative evaluation of various diagnostic techniques for early detection of impaired fetal and neonatal status is presented. An effective complex of organizational, therapeutic, preventive, and rehabilitation activities serve to provide for antenatal care and birth of a healthy infant in a diabetic mother.

[State of blood acid-base balance of the normal pregnant woman, fetus and newborn and with hypoxia and certain aspects of its regulation]. / Sostoianie kislotno-shchelochnogo ravnovesiia krovi beremennoi, ploda i novorozhdennogo v norme i pri gipoksii i nekotorye asperkty ego reguliatsii.

A dependence is studied between changes in the HCO3- and CO2 levels, the content of pyruvate and lactate in blood and the manifestation of disturbances of external respiration in pregnant women suffering from the rheumatic and congenital heart disease. Changes in the carbonic acid level in the blood of pregnant women with pathology of the cardiovascular system correlate reliably, with the frequency and gravity of complications in the course of pregnancy, labour, the state of the fetus and newborn. Some modern methods are considered for regulating acid-base balance, their brief critical analysis is presented with the view of using them in the obstetric practice. Possibility of carbostimulin application in hypoxic states of the mother, fetus and newborn is discussed.