ABSTRACT
The use of immunomodulators in the treatment of subjects with postvaccinal reactions to TEOVac was investigated. The most effective schemes were shown to be those with the use of viferon or combination of arbidol and licopide. The terms of the response signs cupping off were much shorter vs. the cases treated with polyoxidonium. The immunomodulating factors did not affect the intensity of the immunity to the vaccine virus.
Subject(s)
Acetylmuramyl-Alanyl-Isoglutamine/analogs & derivatives , Immunologic Factors/pharmacology , Indoles/pharmacology , Interferon-alpha/pharmacology , Smallpox Vaccine/adverse effects , Tonsillitis , Acetylmuramyl-Alanyl-Isoglutamine/pharmacology , Drug Therapy, Combination , Humans , Immunization/adverse effects , Interferon alpha-2 , Piperazines/pharmacology , Polymers/pharmacology , Recombinant Proteins/pharmacology , Smallpox Vaccine/administration & dosage , Smallpox Vaccine/immunology , Tonsillitis/drug therapy , Tonsillitis/etiology , Vaccinia virus/immunologyABSTRACT
Electron microscopy was applied to the study of the dynamics of endocytosis of smallpox vaccine by alveolar macrophages in intratracheal immunization of guinea pigs; 5 to 15 minutes after administration of smallpox vaccine the viruses were absorbed on the macrophage surface, penetrated into the cells by invagination and vesiculation. A possibility of adaption of smallpox virus in the alveolar macrophages 12 hours after the vaccination was confirmed documentally.
