[Characteristics of the circadian rhythm of hydroxyprolinuria in diabetics]. / Osobennosti sutochnogo ritma gidroksiprolinurii u bol'nykh sakharnym diabetom.

A total of 79 healthy persons (32 men and 47 women) and 109 patients with obvious diabetes mellitus (44 men and 65 women) were examined. The purpose of the investigation was to study the intensity of hydroyxproline excretion in the day-time and at night in the healthy persons and patients with diabetes mellitus with relation to sex, age, clinical type of a course of diabetes and the presence of vascular changes, duration and degree of disease activity and the state of compensation of diabetes mellitus. During a day the examinees collected two portions of urine: daily (6 a. m. to 10 p. m.) and night (10 p. m. to 6 a. m.) in which the concentration of hydroxyproline (in mumol/l) was determined and the intensity of hydroxyprolinuria was calculated (nmol/min), and these indices were determined for the entire daily cycle, too. The degree of expression of changes in hydroxyprolinuria in diabetes mellitus was shown to depend on sex and clinical type of disease: a more significant increase in hydroxyprolinuria was observed in the women, especially in insulin-dependent diabetes, whereas in the male patients such differences were less noticeable. The circadian rhythm was also more disturbed in the women. The determination of the intensity of hydroxyproline excretion can be used for the assessment of a degree of compensation of metabolic processes and the efficacy of therapeutic measures in diabetes mellitus.

[Action of the body fluorine of healthy persons and thyroidopathy patients on the function of hypophyseal-thyroid the system]. / Deistvie ftora, soderzhashchegosia v organizme zdorovykh i bol'nykh tireopatiiami liudei, na funktsional'noe sostoianie gipofiz--shchitovidnaia zheleza.

Altogether 123 persons were examined: 47 healthy persons, 43 patients with thyroid hyperfunction and 33 with thyroid hypofunction. It was established that prolonged consumption of drinking water with a raised fluorine content (122 +/- 5 mumol/l with the normal value of 52 +/- 5 mumol/l) by healthy persons caused tension of function of the pituitary-thyroid system that was expressed in TSH elevated production, a decrease in the T3 concentration and more intense absorption of radioactive iodine by the thyroid as compared to healthy persons who consumed drinking water with the normal fluorine concentration. The results led to a conclusion that excess of fluorine in drinking water was a risk factor of more rapid development of thyroid pathology. Indicators of the fluorine content in daily urine provide most of the information on changes of the fluorine amount in the body.