ABSTRACT
The effect of ascorbic acid on cancer has been a subject of great controversy. This is a follow-up review of the 1979 article by Cameron, Pauling, and Leibovitz published in Cancer Research. In this updated version, the authors address general aspects of ascorbic acid and cancer that have been presented before, while reviewing, analyzing, and updating new existing literature on the subject. In addition, they present and discuss their own mechanistic hypothesis on the effect of ascorbic acid on the cancer cell. The objective of this review is to provide an updated scientific basis for the use of ascorbic acid, especially intravenously as adjuvant treatment in pharmacological nutritional oncology.
Subject(s)
Antioxidants/pharmacology , Ascorbic Acid/pharmacology , Ascorbic Acid/therapeutic use , Neoplasms/drug therapy , Neoplasms/prevention & control , Ascorbic Acid/administration & dosage , Clinical Trials as Topic , Combined Modality Therapy , Dose-Response Relationship, Drug , Drug Resistance, Neoplasm , Humans , Infusions, Intravenous , Pain/drug therapy , Pain/etiology , Palliative CareABSTRACT
The effect of vitamin C in cancer has been a subject of great controversy; mainly because of the inconsistent results obtained by oral intakes of ascorbate when used as an anticancer agent. We believe the intravenous application of ascorbate will provide more consistent results in cancer patients since Vitamin C blood levels attained are substantially higher in a range proven cytotoxic to malignant cells. In this article we will present and discuss our proposed mechanism on the chemotherapeutic activity exhibited by ascorbate.
Subject(s)
Antioxidants/administration & dosage , Ascorbic Acid/administration & dosage , Neoplasms/drug therapy , Orthomolecular Therapy , Humans , Injections, IntravenousABSTRACT
The effect of vitamin C in cancer has been a subject of great controversy; mainly because of the inconsistent results obtained by oral intakes of ascorbate when used as an anticancer agent. We believe the intravenous application of ascorbate will provide more consistent results in cancer patients since Vitamin C blood levels attained are substantially higher in a range proven cytotoxic to malignant cells. In this article we will present and discuss our proposed mechanism on the chemotherapeutic activity exhibited by ascorbate.
