ABSTRACT
Disorders of neurogenesis of cortical and subcortical structures in rat brain limbic system were studied in the offspring of rats that received ethanol during pregnancy. The methods used included the staining of histological sections with cresyl violet, in vitro culture, and electron paramagnetic resonance. Prenatal alcohol intoxication was shown to induce the disturbances in proliferative activity of granular layer cells in the hippocampal dentate gyrus, neuron- and glioblast migration, enhancement of free NO and lipoperoxide production and cell death. This resulted in the changes in the number of neurons in cortical and subcortical structures of rat brain limbic system and in fetal alcohol syndrome formation.
Subject(s)
Ethanol/administration & dosage , Neurogenesis/drug effects , Neurons , Parahippocampal Gyrus , Animals , Cell Death/drug effects , Cell Proliferation/drug effects , Female , Fetal Alcohol Spectrum Disorders/pathology , Lipid Peroxidation/drug effects , Neurons/drug effects , Neurons/metabolism , Neurons/ultrastructure , Nitric Oxide/metabolism , Parahippocampal Gyrus/drug effects , Parahippocampal Gyrus/metabolism , Parahippocampal Gyrus/ultrastructure , Pregnancy , RatsABSTRACT
The number and weight of cells in the cortical and subcortical structures of the cerebral and cerebellar motor system in albino rats after a long-term exposure to toluene. Toluene intoxication proved to kill projection neurons and interneurons in the sensorimotor cortex, ventrolateral thalamic nucleus, caudate nucleus, pallidum, red nucleus, and inferior olivary complex. The decreased number of cerebellar cells was mediated by atrophic changes as indicated by the decrease in the area and dry weight of Purkinje cells. The addition of plaferon LB to the diet attenuated the cytotoxic effect of toluene.
