[Effect of poly-4-vinylpyridine on the quantity of colony-forming cells in the bone marrow and spleen of mice]. / Vliianie poli-4-vinilpiridina na chislo koloneobrazuiushchikh kletok v kostnom mozge i selezenke myshei

Administration of poly-4-vinylpyridine to mice in the maximal tolerance dose doubled the colony-forming units (CFU) and decreased the cell count by 22% in the bone marrow. The increase of CFU number takes place from 2 to 7 days. The cell count in the bone marrow began to decreased 2 hours after the administration of the polymer and remained below the initial level for 5 days; however it began to return to the normal from the second day, reaching the normal figures by the 7th day. In the spleen the CFU rose 9-fold, with a simultaneous development of splenomegaly on account of increased cell count.

[Enhancement of the cooperation of T- and B-lymphocytes in the immune response and the induction of antibody production in B-mice]. / Usilenie kooperatsii T- i B-limfotsitov v immunom otvete i induktsiia antitelogeneza u B-myshei

The effect of poly-4-vinylpyridine and polyacrilic acid on production of antibodyforming cells to the sheep red blood cells in in vivo mixed cultures of T- and B-lymphocytes involved an obvious increase of the immune response. To a lesser extent theimmune response was increased in B-lymphocyte cultures, and no such effect was observed in T-lymphocyte cultures. The poly-4-vinlpyridine and polyacrilic acid were concluded to enhance cooperation between T- and B-lymphocytes and, probably, to replacethe T-lymphocytes function in B-mice.