ABSTRACT
The aim of the study was to evaluate the effectiveness of the suture with a coating of triclosan on the dynamics of postoperative course in emergency surgical patients, comparing the postoperative period in the application of the suture with coating and without it. DESIGN: A prospective cohort with a solid retrospective control group. The efficiency of the application of the suture with a coating of triclosan on the flow dynamics in the early postoperative period 678 emergency surgical patients, comparing the postoperative period when using the coated suture material (292 patients) and without (386 patients). EVALUATION CRITERIA: Time of normalization of body temperature and restore the function of the gastrointestinal tract, the duration of hospital treatment, the need for antibiotic prophylaxis and antibiotic therapy, the incidence of postoperative complications (in general and SSI). It was found a statistically significant effect of the application of the suture with triclosan to reduce the incidence of SSI. The economic effect of using SMT is only by reducing the average duration of hospital treatment amounted to 1 723 238 rubles in one year.
Subject(s)
Surgical Procedures, Operative , Surgical Wound Infection , Sutures , Triclosan/pharmacology , Wound Closure Techniques , Adult , Anti-Infective Agents, Local/pharmacology , Coated Materials, Biocompatible/pharmacology , Cohort Studies , Cost-Benefit Analysis , Emergency Medical Services/economics , Emergency Medical Services/methods , Female , Humans , Male , Materials Testing/methods , Middle Aged , Outcome Assessment, Health Care/methods , Prospective Studies , Russia , Surgical Procedures, Operative/adverse effects , Surgical Procedures, Operative/methods , Surgical Wound Infection/economics , Surgical Wound Infection/etiology , Surgical Wound Infection/prevention & control , Treatment Outcome , Wound Closure Techniques/adverse effects , Wound Closure Techniques/economicsABSTRACT
The history of autoimmune thyroiditis (AIT) and its role in pathophysiology of transition from adolescent hypothalamic syndrome (obesity with rose striae) into early metabolic syndrome is reviewed. Marfanoid phenotype and chronic disequilibrium between local, autacoid-mediated and systemic, hormone-mediated regulation, typical for inherited connective tissue disorders, may promote this transition. Pathogenetic roles of hyperprolactinemia and cytokine misbalance are evaluated and discussed in its pathogenesis.
