ABSTRACT
Trovafloxacin, a new fluoroquinolone, produced bactericidal activity (-0.33 +/- 0.13 delta log10 CFU/ml.h; intravenously [i.v.] administered dose, 15 mg/kg) comparable to that of vancomycin (-0.39 +/- 0.18 delta log10 CFU/ml.h; i.v. admininistered dose, 20 mg/kg) in the treatment of experimental meningitis in rabbits due to a pneumococcal strain highly resistant to penicillin (MIC of penicillin G, 4 micrograms/ml). The combination of both drugs significantly increased (P < 0.05) the killing rate (-0.60 +/- 0.23 delta log10 CFU/ml.h) compared to that produced by either monotherapy. These results were also confirmed in vitro.
Subject(s)
Anti-Infective Agents/therapeutic use , Fluoroquinolones , Meningitis, Pneumococcal/drug therapy , Naphthyridines/therapeutic use , Vancomycin/therapeutic use , Animals , Anti-Bacterial Agents/cerebrospinal fluid , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use , Anti-Infective Agents/cerebrospinal fluid , Anti-Infective Agents/pharmacology , Disease Models, Animal , Drug Therapy, Combination , Meningitis, Pneumococcal/metabolism , Naphthyridines/cerebrospinal fluid , Naphthyridines/pharmacology , Penicillin Resistance , Rabbits , Streptococcus pneumoniae/drug effects , Time Factors , Vancomycin/cerebrospinal fluid , Vancomycin/pharmacologyABSTRACT
A simple model for stability calculation is demonstrated, taking into consideration the velocity constant, its variance, the analytical error by given loss tolerance and the rejection probability. The procedure is explained in detail and exemplified by creatine kinase and acid phosphatase, both relative instable components in control samples.
