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Cell Metab ; 22(3): 408-17, 2015 Sep 01.
Article in English | MEDLINE | ID: mdl-26190649

ABSTRACT

Because human white adipocytes display a high turnover throughout adulthood, a continuous supply of precursor cells is required to maintain adipogenesis. Bone marrow (BM)-derived progenitor cells may contribute to mammalian adipogenesis; however, results in animal models are conflicting. Here we demonstrate in 65 subjects who underwent allogeneic BM or peripheral blood stem cell (PBSC) transplantation that, over the entire lifespan, BM/PBSC-derived progenitor cells contribute ∼10% to the subcutaneous adipocyte population. While this is independent of gender, age, and different transplantation-related parameters, body fat mass exerts a strong influence, with up to 2.5-fold increased donor cell contribution in obese individuals. Exome and whole-genome sequencing of single adipocytes suggests that BM/PBSC-derived progenitors contribute to adipose tissue via both differentiation and cell fusion. Thus, at least in the setting of transplantation, BM serves as a reservoir for adipocyte progenitors, particularly in obese subjects.


Subject(s)
Adipocytes/cytology , Adipogenesis , Bone Marrow Cells/cytology , Bone Marrow Transplantation , Obesity , Peripheral Blood Stem Cell Transplantation , Adipocytes/metabolism , Adolescent , Adult , Aged , Bone Marrow Cells/metabolism , Child , Child, Preschool , DNA/analysis , DNA/metabolism , Female , Humans , Male , Middle Aged , Models, Biological , Obesity/metabolism , Subcutaneous Fat/cytology , Subcutaneous Fat/metabolism , Transplantation, Homologous , Young Adult
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