ABSTRACT
During a three year period, pediatric patients 4 to 16 years old were post-operatively screened for anaesthesia-induced myoglobinuria. All investigated cases had general anaesthesia and received succinylcholine prior to intubation. Anaesthetics were predominantly performed for tonsillectomies and/or adenoidectomies. Of a total of 1704 anaesthetics, 7 (0.4%) resulted in postoperative myoglobinuria without hyperthermia. Anaesthesia-induced myoglobinuria occurs more often than previously presented. This abnormal reaction to succinylcholine is not harmless in all cases. The possible genetic influence on total CPK and its isoenzymes is discussed.
Subject(s)
Anesthesia, General/adverse effects , Creatine Kinase/blood , Myoglobinuria/chemically induced , Child , Child, Preschool , Female , Humans , Isoenzymes , Male , Myoglobinuria/enzymology , Myoglobinuria/genetics , Pedigree , Succinylcholine/adverse effectsABSTRACT
Subependymal and intraventricular hemorrhage are frequent complications of the high risk preterm infant. It has been stated recently that ultrasound may be used to diagnose intraventricular hemorrhage. A comparative prospective study of ultrasound scan (US) with a commercially available B-mode real time linear array US machine and the computed tomography (CT) scan was undertaken to determine the accuracy of US in diagnosing the presence and quantity of subependymal and intraventricular hemorrhage and in following infants with hemorrhage for the development of progressive hydrocephalus. There were 101 patients followed with serial US examination for evidence of subependymal and/or intraventricular hemorrhage. CT correlation was obtained on each patient. The US examination correlated with the CT scan in 77 of these 101 patients. The demonstration of hydrocephalus by US in eight infants with postthemorrhagic hydrocephalus was reliable, and the correlation with CT scan was excellent.
Subject(s)
Cerebral Hemorrhage/diagnosis , Hydrocephalus/diagnosis , Infant, Premature, Diseases/diagnosis , Tomography, X-Ray Computed , Ultrasonography , Cerebral Hemorrhage/complications , Cerebral Hemorrhage/diagnostic imaging , Humans , Hydrocephalus/diagnostic imaging , Hydrocephalus/etiology , Infant, Newborn , Prospective Studies , RiskABSTRACT
Tests are being carried out on 37 patients and healthy volunteers, to differentiate the various, from heart independent, creatin-phosphokinase (CPK) increases, in order to recognize anaesthesia-endangered patients. A rise of the serum-CPK-level, dependent on trauma is insignificant for the anaesthesia. A significant rise of the CPK during a gener al anaesthesia and particularly extreme high values after 24 hours, (example, more than 10 000 U/l) is reason to think of a course of a malignant hyperthermia or myoglobinuria in a subclinical form. Relatives of hyperthermia- or myoglobinuria suspected families are in all cases anaesthesia-endangered, even with a very small rise of CPK-values. The knowledge of these connections is highly important also for internal medical spheres.
Subject(s)
Anesthesia, General/adverse effects , Creatine Kinase/blood , Malignant Hyperthermia/enzymology , Myoglobinuria/enzymology , Acute Disease , Adolescent , Adult , Female , Humans , Male , Myoglobinuria/etiology , Wounds and Injuries/enzymologyABSTRACT
Based on literature and on the results of this open clinical trial we conclude, that there is no connection between application of the above named group of drugs and the change in parameters of haemostasis function, which might lead to a manifest haemorrhagic diathesis. Within the period surveyed of 14 days no case of induced coagulopathy and particularly no thrombocytopenia was seen. The substances under consideration themselves did not exert any anticoagulatory effect nor did they potentiate or inhibit the effect of a concurrently given cumarin derivative.
