The problematic legacy of victim specimens from the Nazi era: Identifying the persons behind the specimens at the Max Planck Institutes for Brain Research and of Psychiatry.

Although 75 years have passed since the end of World War II, the Max Planck Society (Max-Planck Gesellschaft, MPG), successor to the Kaiser Wilhelm Society (Kaiser-Wilhelm-Gesellschaft, KWG), still must grapple with how two of its foremost institutes-the KWI of Psychiatry in Munich and the KWI for Brain Research in Berlin-Buch-amassed collections of brains from victims of Nazi crimes, and how these human remains were retained for postwar research. Initial efforts to deal with victim specimens during the 1980s met with denial and, subsequently, rapid disposal in 1989/1990. Despite the decision of the MPG's president to retain documentation for historical purposes, there are gaps in the available sources. This article provides preliminary results of a research program initiated in 2017 (to be completed by October 2023) to provide victim identifications and the circumstances of deaths.

Smallpox vaccination in the German Empire. Vaccination between biopolitics and moral economy / La vacuna contra la viruela en el imperio alemán. La vacunación entre biopolítica y economía moral

After a smallpox epidemic in Germany in the early 1870s in the wake of the Franco-German War, smallpox vaccination became compulsory by Imperial Law in 1874. The act was hotly debated in parliament and in public and earlier resistance against vaccination developed into a political anti-vaccination movement. For this reason, the German government adopted a number of safety measures. The current article describes, firstly, vaccination practices, regulations and policies in the German states up to the 1870s and the biopolitical developments that led to the Imperial Law on compulsory smallpox vaccination in 1874. Secondly, the article sketches the public debate and critique regarding vaccination asking why compulsory vaccination succeeded in Germany. The article describes the measures implemented by the German government to promote compulsory vaccination and acceptance of the Imperial Law: initially, smallpox vaccines were manufactured by state-run production sites and supervised by local authori­ties. Empire-wide statistics were collated documenting the success of vaccination as well as related side-effects. From a government perspective, these precautions could be interpreted as a technology of trust

Después de una epidemia de viruela en Alemania a principios de la década de 1870 a raíz de la guerra francoalemana, la vacuna antivariólica se hizo obligatoria por Ley Imperial en 1874. La ley se debatió acaloradamente en el parlamento y en pú­blico, y la resistencia ya existente contra la vacunación se convirtió en un movimiento político antivacunas. Por ello, el gobierno alemán adoptó una serie de medidas de seguridad. El artículo actual describe, en primer lugar, las prácticas, regulaciones y políti­cas de vacunación en los estados alemanes hasta la década de 1870, y los desarrollos biopolíticos que llevaron a la Ley Imperial sobre la vacunación antivariólica obligatoria en 1874. En segundo lugar, se esbozan el debate público y la crítica sobre la vacunación, preguntando por qué la vacunación obligatoria tuvo éxito en Alemania. Se describen las medidas aplicadas por el gobierno alemán para promover la vacunación obligatoria y la aceptación de la Ley Imperial: inicialmente, las vacunas contra la viruela se fabricaban por centros de producción estatales supervisados por las autoridades locales. Se recopilaban estadísticas de todo el imperio que documentaban el éxito de la vacunación, así como los efectos secundarios relacionados. Desde la perspectiva del gobierno, estas precauciones podrían interpretarse como una tecnología de confianza

"Ehrlich färbt am längsten". Sichtbarmachung bei Paul Ehrlich.

"Staining is the Best Policy". Visualization in the work of Paul Ehrlich. For nearly all of his life, the biomedical scientist Paul Ehrlich dedicated himself to work on dyes and staining at the interface between so-called color-chemistry and histopathology. The article begins by sketching out the field of histopathology at the junction of pathological anatomy, microtechniques, and the development of chemical dyes in the early 1870s when Ehrlich began his training as a medical student. The article explores Ehrlich's work staining first tissue and blood, and then pathogens and vital staining in the 1880s. In the late 1880s and 1890s, Ehrlich experimented with dyes as therapeutic agents. Staining made the invisible visible, revealing cell structures, pathogens, or vital physiological processes within the cell itself. The article shows how visualization became an essential - albeit laborious and painstaking - element in the epistemic process of Ehrlich's work. The production of histological specimens required special skills acquired through extensive practice, especially in the techniques of visualization, manipulation, observation, and tacit understanding. These practices were needed because it was increasingly necessary to produce objective results once the various techniques of visualization came to be assessed within a discourse on objectivity. Visualization itself became an epistemic object and was ultimately "more important than the subject matter itself".

The dynamics of Wertbestimmung.

The procedure of Wertbestimmung played a vital role in the implementation of serum therapy and the standardization of mass-produced pharmaceuticals. In fin-de-siècle Germany, a legal framework was put in place to guarantee serum quality and safety and to minimize any associated public health risks. Because the sera were biological remedies, it was difficult to produce them in uniform quality and the procedure of Wertbestimmung, i.e. determining the potency of the serum based on an objective and comparable value, was extremely complex. Various agents such as bacteria cultures, serum hosts, or test animals had to be regulated. In the years after 1895, numerous efforts to stabilize the procedures of Wertbestimmung were undertaken by serum producers and members of the state-run survey institute responsible for overseeing serum production. Despite efforts to stabilize the framework and to generate a reliable reference system, the framework's environment and agents were in constant flux: new producers entered the market and procedures were expanded to include other biologicals as well. The article describes the dynamics involved in the sustained efforts to maintain a stable framework in the face of constant alterations between 1895 and the 1920s.

Diphtheria serum and serotherapy. Development, production and regulation in fin de siècle Germany.

The development, production and state regulation of diphtheria serum is outlined against the background of industrialisation, standardization, falling standards of living and rising social conflict in fin de siècle Germany. On one hand, diphtheria serum offered a cure for an infectious disease and was a major therapeutic innovation in modern medicine. On about its side effects or long-term impact. Moreover, serum therapy promised high profitsthe other hand, the new serum was a remedy of biological origin and nothing was known for manufacturers who succeeded in stabilizing the production process and producing large quantities of serum in so-called industrial production plants. To minimize public health risks, a broad system of state regulation was installed, including the supervision of serum production and distribution. The case of diphtheria serum illustrates the indirect forms of government supervision and influence adopted in the German Empire and the cooperation and networking among science, state and industry.

[The anti-diphtheria serum and the case of Langerhans]. / Das Diphtherie-Serum und der Fall Langerhans.

An eighteen-month old boy called Ernst Langerhans died shortly after being injected with a prophylactic dose of anti-diphtheria serum in April 1896. The father, a well-known pathologist in Berlin, claimed, in the obituary notice, that his son had been poisoned by Behring's anti-diphtheria serum. This paper describes the tragic events of Spring 1896: the death of Ernst Langerhans, the official investigations that followed as well as the reactions in the daily newspapers and the medical journals. The death of Ernst Langerhans afforded the opponents of the new serotherapy an opportunity to call into question the whole immunological concept. Supporters of the serotherapy, in turn, defended it against these attacks. The spectacular nature of Ernst Langerhans's death combined with the fact that he came from a prominent family of physicians made the event a public scandal. The tuberculine affair which had happened only a few years earlier was another reason for the public concern. Finally, the "Langerhans case" was a scandal because of the way in which Robert Langerhans published the death notice also causing resentment within the scientific community. Indeed, the publication of the accusation was one of the reasons why the "Langerhans case" failed to provoke a crisis with respect to the new therapy, as the central argument was displaced onto wider ethical questions. Furthermore, the medical administration had learned from the tuberculine affair, and had subsequently implemented a large confidence-inspiring system of quality control. The "official" cause of death, following the investigations into the case, was proclaimed to be an accident; a tragic piece of bad luck.