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HIV type 1 infection in Pygmy hunter gatherers is from contact with Bantu rather than from nonhuman primates.

Ndembi, Nicaise; Habakkuk, Yumo; Takehisa, Jun; Takemura, Taichiro; Kobayashi, Eiji; Ngansop, Charlotte; Songok, Elijah; Miura, Tomoyuki; Ido, Eiji; Hayami, Masanori; Kaptue, Lazare; Ichimura, Hiroshi.

AIDS Res Hum Retroviruses ; 19(5): 435-9, 2003 May.

Article in English | MEDLINE | ID: mdl-12816089

ABSTRACT

To investigate the route of zoonotic transmission of HIV-1, we isolated three and seven HIV-1 strains from 449 Pygmy hunter gatherers and 169 neighboring Bantu, respectively, in southern Cameroon. Phylogenetic analysis based on pol-integrase and env-C2V3 sequences revealed that strains from Pygmies were 1CRF02_AG/CRF02_AG, 1 subtype G/CRF02 AG (pol/env), and 1 CRFll_cpx/CRF11_cpx, and that those from Bantu were 2 CRF02_AG/CRF02_AG, 1 CRF02_AG/CRF01_AE/A, 1 CRF02_AG/subtype A, 1 G/A, 1G/CRF02_AG, and 1 unclassified fH. CRF02_AG and CRF11_cpx have been identified in Cameroon. The results suggest that HIV-1 has been introduced into Pygmies through their neighboring Bantu rather than directly from nonhuman primates.

Subject(s)

HIV Infections/ethnology , HIV Infections/transmission , HIV-1/classification , HIV-1/genetics , Native Hawaiian or Other Pacific Islander , Adult , Aged , Animals , Cameroon/ethnology , Ethnicity , Female , Gene Products, env/genetics , Gene Products, pol/genetics , HIV Envelope Protein gp120/genetics , HIV Infections/virology , HIV Integrase/genetics , Humans , Male , Middle Aged , Molecular Sequence Data , Peptide Fragments/genetics , Phylogeny , Racial Groups , Sequence Analysis, DNA

ABSTRACT

Subject(s)

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